Toxicity of Silver Nanoparticles in the Presence of Zinc Oxide Nanoparticles Differs for Acute and Chronic Exposures in Zebrafish

Mahjoubian, Maryam; Naeemi, Akram Sadat; Moradi‐Shoeili, Zeinab; Tyler, Charles R.; Mansouri, Borhan

doi:10.1007/s00244-022-00965-0

Cited by 15 publications

(2 citation statements)

References 89 publications

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“…The toxicity of the following nanoparticles (nAg, nCeO 2 and nCuO) was determined individually and in 2 mixtures to Oncorhynchus mykiss trout juveniles (2–4 cm length). The fish were exposed to sublethal concentrations of 50 µg/L of nAg, 50 µg/L nCuO and 10 µg/L nCeO based on previous studies to ensure absence of acutely lethal effects [ 21 , 22 ]. Moreover, the selection of the 50 µg/L and 10 µg/L concentration was selected based on the observation that these elements are found in municipal effluents and combined sewer overflows at concentrations between 0.1 and 100 µg/L [ 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Investigation on the Toxicity of Nanoparticle Mixture in Rainbow Trout Juveniles

et al. 2023

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The environmental impacts of nanoparticle mixtures in the aquatic environment is not well understood. The purpose of this study examined the sub-lethal toxicity of low concentrations (ug/L range) of selected nanoparticles alone and in mixtures in juvenile trout. Fish were exposed to to individual and two environmentally relevant mixtures of silver (nAg), copper oxide (nCuO) and cerium oxide (nCeO) nanoparticles for 96 h at 15 °C. After the exposure period, fish were depurated overnight and tissue levels in Ag, Ce, Cu and Zn were determined along with a suite of effects biomarkers such as oxidative stress/inflammation, denatured protein tagging (ubiquitin), DNA strand breaks (genotoxicity) and acetylcholinesterase (AChE) activity. The data showed that these nanoparticles behaved as suspended matter but were nevertheless bioavailable for fish with bioconcentration factors of 6, 8 and 2 for nAg, nCeO and nCuO respectively. Only nCuO alone increased malonaldehyde (lipid peroxidation) contents but all nanoparticles increased DNA damage, protein-ubiquitin labeling, and decreased AChE activity. Globally, the toxicity of nCeO and nCuO was generally stronger than nAg, and antagonist effects were found in the mixtures. The interactions involved in these antagonisms are not well understood but do not involve the liberation of free ions and labile zinc in tissues. In conclusion, the bioavailability and toxicity of these nanoparticles are influenced by mixtures of nanoparticles, which is likely to occur in contaminated environments.

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Section: Methodsmentioning

confidence: 99%

Investigation on the Toxicity of Nanoparticle Mixture in Rainbow Trout Juveniles

et al. 2023

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“…Because of its long-term tolerance to several aquatic stresses, O. niloticus has been used as animal model in many toxicological studies (Ibrahim et al 2021 ). Additionally, various biomarkers have been frequently used to assess NPs toxicity in aquatic species (Kaviani et al 2019 ; Abdel-Khalek et al 2020a ; Mahjoubian et al 2023b ). One promising biomarker, for instance, was the change in antioxidant status (Ozmen et al 2020 ; García-Medina et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Badran,

Hamed

2024

Environ Sci Pollut Res

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Scientists worldwide have noticed that cutting-edge technologies can be used to produce nanoparticles (NPs) in a sustainable and environmentally friendly way, instead of the old methods. However, the effectiveness of this approach for aquatic environments and species still needs to be determined. Therefore, this study aims to compare between the toxicity of green and chemically synthesized copper oxide nanoparticles (GS and CS) CuO NPs at two different concentrations on Nile tilapia (Oreochromis niloticus) using various biomarkers. CuO NPs’ formation was proved, and their different characterizations were recorded. Then, the fish samples were randomly allocated in glass aquaria into five groups: one acted as a control group, and the other groups were exposed to two concentrations (25 and 50 mg/L) of GS-CuO NPs and CS-CuO NPs, separately, for 4 days. After the experimental time, in all groups that were exposed to two concentrations of both synthesized CuO NPs, the results revealed that glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS) levels were elevated in the liver and gills compared to glutathione reduced (GSH) content, which showed a significant decline. Bioaccumulation of Cu was more prevalent in the liver than in the gills, and the highest bioaccumulation capacity was more evident in the groups exposed to CS-CuO NPs. Moreover, the bioaccumulation of Cu caused severe histological changes in the liver and gills. In conclusion, the results suggested that GS-CuO NPs revealed less toxicity than CS-CuO NPs to the examined fish. However, they are still toxic, and their toxic effect cannot be overlooked.

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Effect of long-term exposure of mixture of ZnO and CuO nanoparticles on Scenedesmus obliquus

Rana,

Kumar

2023

Ecotoxicology

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Toxicity of Silver Nanoparticles in the Presence of Zinc Oxide Nanoparticles Differs for Acute and Chronic Exposures in Zebrafish

Cited by 15 publications

References 89 publications

Investigation on the Toxicity of Nanoparticle Mixture in Rainbow Trout Juveniles

Investigation on the Toxicity of Nanoparticle Mixture in Rainbow Trout Juveniles

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Effect of long-term exposure of mixture of ZnO and CuO nanoparticles on Scenedesmus obliquus

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