Toxicity of the pyrethroid bifenthrin insecticide

Yue, Yang; Wu, Nanxiang; Wang, Chunlei

doi:10.1007/s10311-018-0765-0

Cited by 68 publications

(28 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…pyrethrin and the synthetic organic compounds class). [61][62][63] Since then several pesticides have been introduced in enantiomerically enriched forms to enhance bioactivity. 40,62 Pyrethroids usually have several chiral centers, often at the cyclopropane ring, creating multiple stereoisomers with variable degrees of toxicity.…”

Section: Discussionmentioning

confidence: 99%

Toxicity and repellent activity of monoterpene enantiomers to rice weevils (Sitophilus oryzae)

Fouad

Tavares²,

Zanuncio

2021

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND: The rice weevil, Sitophilus oryzae (L., 1763) (Coleoptera: Curculionidae), is a stored grain/seed pest of several crops. Botanicals represent an option to manage this pest, especially those with high toxicity determined by its structure and physicochemical properties and low residue left behind on treated grains/seeds. Enantiomers are bioactive molecules in organic processes. The aim of this study was to evaluate the insecticidal activity of two enantiomeric forms of the monoterpenes citronellal, limonene, linalool, menthone and ⊍-pinene against S. oryzae adults through contact, fumigant and repellent assays.RESULTS: All results were compared with absolute acetone as the negative control and those from contact assays also with malathion as the positive control. (S)-(−)-linalool was the most toxic by contact to S. oryzae and (S)-(−)-menthone through fumigation, while the two enantiomeric forms of menthone and ⊍-pinene were the best repellents. CONCLUSIONS: The high toxicity of only one of the two monoterpene enantiomers showed the importance of form and percentage of enantiomer in the commercial product, which affect the success of the product to controlling S. oryzae.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicity and repellent activity of monoterpene enantiomers to rice weevils (Sitophilus oryzae)

Fouad

Tavares²,

Zanuncio

2021

Pest Management Science

View full text Add to dashboard Cite

show abstract

“…Morgan et al investigated 8 pyrethroid residues in repeated duplicated-diet solid food samples of 50 adults during the period of 2009–2011, and found that at least one pyrethroid or pyrethroid degradate was found in 49% and 2% of the monitored samples, respectively [ 8 ]. Due to the neurotoxicity, hepatotoxicity, development toxicity, and digestive system toxicity of pyrethroid pesticides for animals and human beings, such high residues at the mg kg −1 level in food present a healthy risk [ 9 ]. European Food Safety Authority (EFSA) formulated a maximum residue level of cypermethrin in the range of from 0.05 mg kg −1 to 2 mg kg −1 , based on the risk assessment, and cypermethrin residues in some monitored food samples reported by previous studies exceeded the maximum residue levels (MRLs) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Three Typical Metabolites of Pyrethroid Pesticides in Tea Using a Modified QuEChERS Sample Preparation by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry

Chen

Wang

Liu

et al. 2021

Foods

View full text Add to dashboard Cite

Pyrethroid pesticides are widely used on tea plants, and their residues of high frequency and concentration have received great attention. Until recently, the residues of typical metabolites of pyrethroid pesticides in tea were unknown. Herein, a modified “quick, easy, cheap, effective, rugged and safe” (QuEChERS) method for the determination of three typical metabolites of pyrethroid pesticides in tea, using ultra performance liquid chromatography tandem mass spectrometry, was developed. The mixture of florisil, octadecylsilane, and graphite carbon black was employed as modified QuEChERS adsorbents. A Kinetex C18 column achieved good separation and chromatographic peaks of all analytes. The calibration curves of 3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA) were linear in the range of 0.1–50 ng mL−1 (determination coefficient R2 higher than 0.999), and that of cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid (TFA) was in the range of 1–100 ng mL−1 (R2 higher than 0.998). The method was validated and recoveries ranged from 83.0% to 117.3%. Intra- and inter-day precisions were lower than or equal to 13.2%. The limits of quantification of 3-PBA, 4-F-3-PBA, and TFA were 5, 2, and 10 μg kg−1, respectively. A total of 22 tea samples were monitored using this method, and 3-PBA and TFA were found in two green tea samples.

show abstract

“…2,3 Bifenthrin is a third-generation pyrethroid insecticide, which is listed as a moderately hazardous compound by the World Health Organization. 4,5 With its large-scale application in fruits, vegetables, tea, and other agricultural products, even environmental health and other fields, 3,6,7 the dietary exposure risk of bifenthrin to consumers has also aroused concern. Bifenthrin's main mode of action is to destroy voltage-gated sodium channels, which can change the release of neurotransmitters and further damage nerve function.…”

Section: Introductionmentioning

confidence: 99%

“…Their proportion in the global pesticide market is increasing. , Bifenthrin is a third-generation pyrethroid insecticide, which is listed as a moderately hazardous compound by the World Health Organization. , With its large-scale application in fruits, vegetables, tea, and other agricultural products, even environmental health and other fields, ,, the dietary exposure risk of bifenthrin to consumers has also aroused concern. Bifenthrin’s main mode of action is to destroy voltage-gated sodium channels, which can change the release of neurotransmitters and further damage nerve function. , Studies have shown that bifenthrin has developmental toxicity and neurotoxicity and can cause behavioral disorders in mammals and can also cause fat accumulation and immunological abnormalities. ,,− Bifenthrin has also been reported to induce estrogenic effects in fish and to exhibit a life-stage-dependent estrogenic response . According to the WHO/FAO Joint Meeting on Pesticide Residues (JMPR), the residue definition of bifenthrin for compliance with the MRL and for estimation of dietary intake for plant and animal commodities is bifenthrin…”

Section: Introductionmentioning

confidence: 99%

Dissipation, Residue, and Dietary Risk Assessment of Bifenthrin, Bifenazate, and Its Metabolite Bifenazate–Diazene in Apples Based on Deterministic and Probabilistic Methods

Zhao

Chai

Liu

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

A rapid, sensitive, and effective multiresidue analytical method was established to investigate the degradation rate and final residues of bifenthrin, bifenazate, and its metabolite bifenazate–diazene in apples, and the dietary risk of consumers was evaluated. The residues of bifenthrin, bifenazate, and bifenazate–diazene in apple samples from 12 different apple-producing areas of China were determined by high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). The average recoveries of the three compounds in apples were 88.4–104.6%, and the relative standard deviations (RSDs) were 1.3–10.5%. The limit of quantification (LOQ) for each compound was 0.01 mg/kg. Although the degradation half-lives of bifenthrin, bifenazate, and bifenazate–diazene were 17.8–28.9, 4.3–7.8, and 5.0–5.8 days, under good agricultural practice (GAP) conditions, the final residues of bifenthrin, bifenazate, and the sum of bifenazate and its metabolite bifenazate–diazene in apples were <0.01–0.049, < 0.01–0.027, and <0.02–0.056 mg/kg, respectively, which were lower than the maximum residue limit (MRL) in China. By comparing the deterministic model with the probabilistic model, the results of the probabilistic model at the P95 level (12.91–48.9% for bifenthrin, 17.48–52.01% for bifenazate including its metabolite) were selected as reasonable assessment criteria for chronic dietary risk, and the acute risk was at the P99.9 level (3.00–15.59% for bifenthrin). Although the exposure risk calculated by both the deterministic model and the probabilistic model was less than 100%, the risk to children is significantly higher than that of the general population. This suggests that in future research and policy making, we should pay more attention to the risk of vulnerable groups such as children.

show abstract

Toxicity of the pyrethroid bifenthrin insecticide

Cited by 68 publications

References 124 publications

Toxicity and repellent activity of monoterpene enantiomers to rice weevils (Sitophilus oryzae)

Toxicity and repellent activity of monoterpene enantiomers to rice weevils (Sitophilus oryzae)

Determination of Three Typical Metabolites of Pyrethroid Pesticides in Tea Using a Modified QuEChERS Sample Preparation by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry

Dissipation, Residue, and Dietary Risk Assessment of Bifenthrin, Bifenazate, and Its Metabolite Bifenazate–Diazene in Apples Based on Deterministic and Probabilistic Methods

Contact Info

Product

Resources

About