Toxicity of the pyrethroid insecticide fenvalerate to a fresh water fish, Tilapia mossambica (Peters): Changes in glycogen metabolism of muscle

Radhaiah, V.; Rao, K. Jayantha

doi:10.1016/0147-6513(90)90086-k

Cited by 12 publications

(4 citation statements)

References 11 publications

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“…and Radhaiah and Reddy (1989) found fenvalerate-induced changes in the activity and isoenzyme pattern of lactate dehydrogenase (LDH) in the liver, gill, muscle and brain of the freshwater teleost, Oreochromis mossambicus. Fenvalerate has been reported to cause a significant reduction in activity of succinate dehydrogenase (SDH) and malate dehydrogenase (MDH), but induction of LDH activity in the liver of Tilapia mossambica (Radhaiah and Rao 1990). Shakoori et al (1996) reported significant decrease in liver LDH activity after 3 weeks of sub lethal concentration of fenvalerate exposure to freshwater fish, C. idella, while Tripathi and Verma (2004) reported decrease in LDH activity in C. batrachus exposed to fenvalerate.…”

Section: Histopathological Alterationsmentioning

confidence: 96%

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Prusty¹,

Meena

Mohapatra

et al. 2015

Int Aquat Res

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As a new class of agricultural insecticides, synthetic pyrethroids are widely used to control insect pests. Synthetic pyrethroids have been shown to enter the aquatic environment from agricultural runoff or drift from aerial and ground-based spraying applications posing threat to fishes which are less tolerant to pesticides through direct exposure. These insecticides interfere with the sodium channel of the nervous system resulting in prolonged sodium tail current. Widespread application of these chemicals has warranted the attention of the ecologist to understand the impact of these chemicals on the aquatic environment. In this perspective, an updated account of toxicological evaluation of three type II synthetic pyrethroids, viz. deltamethrin, cypermethrin and fenvalerate in terms of their physico-chemical, metabolic, hematological, histological, behavioral and reproductive aspects with respect to the fishes has been presented which may be useful for policy makers, academics, environmental scientists and agricultural professionals needing ready access to this information. The aim of the present synoptic literature appraisal was to summarize the main effect of current use, type II synthetic pyrethroids (deltamethrin, cypermethrin and fenvalerate) on aquatic environment due to their persistence and accumulation. This article will focus on non-target organisms in inland fresh water environment with special reference to fin fishes and will critically evaluate the toxicity of these pyrethroids in terms of growth inhibition, metabolic disorders, neurotoxicity, reproductive failure, enzymatic dysfunction, haematological alterations, and tissue damages. The rationalized information in this milieu may be useful in ecological risk evaluation and human health management as fish serves as an important bio-indicator for aquatic systems health.

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Section: Histopathological Alterationsmentioning

confidence: 96%

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Prusty¹,

Meena

Mohapatra

et al. 2015

Int Aquat Res

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“…Therefore, it is possible that these later developmental stages can be more susceptible to PM toxicity, once the gill innervation and respiration start between 5 and 7 dpf [60]. Fish are the most sensitive vertebrate organisms to SP due to their chemical lipophilic property while having a high absorption rate through the gills [61].…”

Section: Discussionmentioning

confidence: 99%

Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish

Nunes

Schimith

Costa-Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

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Permethrin (PM) is a synthetic pyrethroid insecticide widely used as domestic repellent. Damage effects to nontarget organisms have been reported, particularly in the early stages of development. Studies indicate redox unbalance as secondary PM effect. Therefore, our goal was to investigate the acute PM effects on larval zebrafish. Larvae (6 days postfertilization) were exposed to PM (25–600 μg/L) during 24 hours, and 50% lethal concentration was estimated. For subsequent assays, the sublethal PM concentrations of 25 and 50 μg/L were used. PM increased anxiety-like behaviors according to the Novel Tank and Light-Dark tests. At the molecular level, PM induced increased ROS, which may be related to the increased lipid peroxidation, DNA damage, and apoptosis detected in PM-exposed organisms. In parallel, upregulation of the antioxidant system was detected after PM exposure, with increased superoxide dismutase, glutathione S-transferase and glutathione reductase activities, and thiol levels. The increased of Nrf2 target genes and the activation of an electrophile response element-driven reporter Tg(EPRE:LUC-EGFP) suggest that the Nrf2 pathway can mediate a fast response to PM, leading to antioxidant amplification. By using high-resolution respirometry, we found that exposure to PM decreased the oxygen consumption in all respiratory stages, disrupting the oxidative phosphorylation and inhibiting the electron transfer system, leading to decrease in bioenergetics capacity. In addition, PM led to increases of residual oxygen consumption and changes in substrate control ratio. Glucose metabolism seems to be affected by PM, with increased lactate dehydrogenase and decreased citrate synthase activities. Taken together, our results demonstrated the adverse effects of acute sublethal PM concentrations during larval development in zebrafish, causing apparent mitochondrial dysfunction, indicating a potential mechanism to redox unbalance and oxidative stress, which may be linked to the detected cell death and alterations in normal behavior patterns caused by acute PM exposure.

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“…Alterations of carbohydrate metabolism have been observed in several polluted environments, as reported for O. mykiss exposed to sewage e%uent (Wieser and Hinterleitner, 1980), for ¹ilapia mossambica exposed to fenvalerate (Radhaiah and Rao, 1990), and for several "sh species exposed to bleached kraft mill e%uents (Haley et al, 1995;Sandstrom et al, 1988;Adams et al, 1992). Most studies attribute an increased growth rate or larger visceral lipid accumulation of contaminated "sh to an increased abundance of food in a polluted environment, which may partially account for the observed changes.…”

Section: Discussionmentioning

confidence: 80%

Metabolic Enzyme Activities in Fish Gills as Biomarkers of Exposure to Petroleum Hydrocarbons

Gagnon¹,

Holdway²

1999

Ecotoxicology and Environmental Safety

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Toxicity of the pyrethroid insecticide fenvalerate to a fresh water fish, Tilapia mossambica (Peters): Changes in glycogen metabolism of muscle

Cited by 12 publications

References 11 publications

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish

Metabolic Enzyme Activities in Fish Gills as Biomarkers of Exposure to Petroleum Hydrocarbons

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