1994
DOI: 10.1016/s0140-6736(94)91203-3
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Toxicity of tretinoin in acute promyelocytic leukaemia

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Cited by 5 publications
(2 citation statements)
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“…The exact pathological mechanisms of peripheral neuropathy are unknown in our patient, although they may be related to vasculitis; 11 for ethical reasons, neuromuscular biopsy was not performed in this 16‐year old patient. Nevertheless, we suggest that, although our young patient did not exhibit tretinoin‐associated facial irritation (which might have increased topical tretinoin absorption through skin), he may have been more sensitive than adults to the neurological effects of topical tretinoin, as mentioned previously with oral tretinoin 12 . In addition, our patient did not use gauze pad or cotton swabs to apply topical tretinoin; in essence, he exhibited fingertips' desquamation, which may have also increased topical tretinoin absorption through skin.…”
mentioning
confidence: 55%
“…The exact pathological mechanisms of peripheral neuropathy are unknown in our patient, although they may be related to vasculitis; 11 for ethical reasons, neuromuscular biopsy was not performed in this 16‐year old patient. Nevertheless, we suggest that, although our young patient did not exhibit tretinoin‐associated facial irritation (which might have increased topical tretinoin absorption through skin), he may have been more sensitive than adults to the neurological effects of topical tretinoin, as mentioned previously with oral tretinoin 12 . In addition, our patient did not use gauze pad or cotton swabs to apply topical tretinoin; in essence, he exhibited fingertips' desquamation, which may have also increased topical tretinoin absorption through skin.…”
mentioning
confidence: 55%
“…Children appear to be more sensitive to the neurotoxicity of ATRA and should probably receive lower doses of ATRA. [19] Toxicity During Treatment of APML…”
Section: Toxicities Of Systemic Retinoid Therapymentioning
confidence: 99%