Toxicity of β- and -γ-hexachlorocyclohexane in rats of different ages

Srinivasan, Krishnapura; Mahadevappa, Kavita; Radhakrishnamurty, R.

doi:10.1007/bf01700955

Cited by 7 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, histological studies of renal tubules indicated more severe degenerative changes in the β-HCH treated rats as compared to control rats (17). Dietary βor γ-HCH treatment of variously aged rats also resulted in liver toxicity including liver enlargement and liver fatty metamorphosis (18). Both male and female rats receiving 250 mg/kg β-HCH had significantly lower red blood cell counts, white blood cell counts, hemoglobin concentrations, and packed cell volumes as compared to controls (19).…”

Section: Toxicitymentioning

confidence: 94%

Differential Toxicity and Environmental Fates of Hexachlorocyclohexane Isomers

Willett

Ulrich

Hites

1998

Environ. Sci. Technol.

821

451

View full text Add to dashboard Cite

The differential environmental fates and toxicities of the various hexachlorocyclohexane (HCH) isomers including lindane and isomers in the technical mixture will be the focus of this review. HCHs are one of the most widely used and most readily detected organochlorine pesticides in environmental samples. The relatively high volatility of HCH has led to global transport, even into formerly pristine locations such as the Arctic. Certain HCHs cause central nervous system, reproductive, and endocrine damage. Because γ-HCH is rapidly metabolized, the β-HCH isomer is consistently found in higher concentrations in human fat, blood, and breast milk. In contrast, Rand γ-HCH are the most prevalent isomers in soil, water, and air samples. The ratio of the Rto γ-isomers can be used to track global transport of HCHs. A new area of HCH research focuses on the selective degradation of the two R-HCH enantiomers in various environmental matrices. These HCH issues and recommendations for future HCH research are presented in this review.

show abstract

Section: Toxicitymentioning

confidence: 94%

Differential Toxicity and Environmental Fates of Hexachlorocyclohexane Isomers

Willett

Ulrich

Hites

1998

Environ. Sci. Technol.

821

451

View full text Add to dashboard Cite

show abstract

“…In the general population as well as in occupational workers, the accumulation of β-HCH assumed a linear increase over the time of exposure [ 51 ]. In rats, the distribution pattern for β-HCH was found to decrease in the sequence: fat > kidney > lungs > liver > muscle > heart > spleen > brain > blood [ 52 ]. Animal-based studies using dermal application mainly focused on clarifying the final destination of β-HCH isomers in the body, and little is known about skin toxicity.…”

Section: Discussionmentioning

confidence: 99%

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes

Papaccio,

Caputo,

Iorio

et al. 2024

Cells

View full text Add to dashboard Cite

Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major clinical risk factors for melanoma include fair skin, an increased number of nevi, the presence of dysplastic nevi, and a family history of melanoma. However, several external inducers seem to be associated with melanoma susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol consumption, and heavy metals. In recent years, epidemiological studies have highlighted a potential risk of β-hexachlorocyclohexane (β-HCH), the most studied organochlorine pesticide, causing cancer induction including melanoma. Methods: We evaluated in vitro the impact of this pollutant on epidermal and dermal cells, attempting to describe mechanisms that could render cutaneous cells more prone to oncogenic transformation. Results: We demonstrated that β-HCH impacts melanocyte biology with a highly cell-type specific signature that involves perturbation of AKT/mTOR and Wnt/β-catenin signaling, and AMPK activation, resulting in lowering energy reserve, cell proliferation, and pigment production. Conclusions: In conclusion, long-term exposure to persistent organic pollutants damages melanocyte metabolism in its function of melanin production with a consequent reduction of melanogenesis indicating a potential augmented skin cancer risk.

show abstract