2020
DOI: 10.1021/acs.chemrestox.0c00285
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Toxicity Profile and Pharmacokinetic Study of Antibiotic Mixtures, Gentamicin and Vancomycin, in Rat Plasma by Ecofriendly Liquid Chromatography Coupled Tandem Mass Spectrometry

Abstract: The global burden of bacterial infection and antimicrobial resistance increases the demand to associate more than one antibiotic to fight life-threatening bacteria. Therefore, there is a great necessity to develop simple and sensitive methods for routine analysis of clinical samples. Therapeutic drug monitoring, bioequivalence, and pharmacokinetic studies are essential to ensure drug efficiency and safety. Herein, therefore, the first ecofriendly liquid chromatography −tandem mass spectrometry (LC–MS/MS) metho… Show more

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Cited by 9 publications
(4 citation statements)
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“…Intensified antibiotic misuse events with accompanying bacterial resistance have drawn increasing global concern due to various adverse food safety and human health effects. , As a widely used broad-spectrum aminoglycoside antibiotic, gentamicin (GEN) with conspicuous effectiveness is extensively used in livestock production for treating infections of poultry and aquatic animals such as mastitis, pneumonia, and bacillary diarrhea. , Nonetheless, widespread negligence of proper withdrawal time led to residues in the environment exacerbating the emergence of superbugs, and potential accumulation in animal-derived food products aggravates the possibility of humans to suffer serious side effects (ototoxicity, nephrotoxicity, and vestibulotoxicity). Based on these facts, it is therefore important to develop an efficient and reliable warning detection platform for reporting the fouling levels of Gen, thus ultimately safeguarding food safety and public health. From this motivation, Gen monitoring has advanced significantly from the microbiological method to analytical techniques, including capillary electrophoresis, HPLC/MS/MS, LC-MS/MS, and ic-ELISA . Although the analytical performance in aforementioned technologies is satisfactory, specialized staff, lengthy procedures, and cumbersome pretreatment fail to satisfy the ever-increasing requirements of on-site surveillance concerns, especially for the emergency cases in poor economies and developing countries .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Intensified antibiotic misuse events with accompanying bacterial resistance have drawn increasing global concern due to various adverse food safety and human health effects. , As a widely used broad-spectrum aminoglycoside antibiotic, gentamicin (GEN) with conspicuous effectiveness is extensively used in livestock production for treating infections of poultry and aquatic animals such as mastitis, pneumonia, and bacillary diarrhea. , Nonetheless, widespread negligence of proper withdrawal time led to residues in the environment exacerbating the emergence of superbugs, and potential accumulation in animal-derived food products aggravates the possibility of humans to suffer serious side effects (ototoxicity, nephrotoxicity, and vestibulotoxicity). Based on these facts, it is therefore important to develop an efficient and reliable warning detection platform for reporting the fouling levels of Gen, thus ultimately safeguarding food safety and public health. From this motivation, Gen monitoring has advanced significantly from the microbiological method to analytical techniques, including capillary electrophoresis, HPLC/MS/MS, LC-MS/MS, and ic-ELISA . Although the analytical performance in aforementioned technologies is satisfactory, specialized staff, lengthy procedures, and cumbersome pretreatment fail to satisfy the ever-increasing requirements of on-site surveillance concerns, especially for the emergency cases in poor economies and developing countries .…”
Section: Introductionmentioning
confidence: 99%
“…5−7 Based on these facts, it is therefore important to develop an efficient and reliable warning detection platform for reporting the fouling levels of Gen, thus ultimately safeguarding food safety and public health. From this motivation, Gen monitoring has advanced significantly from the microbiological method to analytical techniques, including capillary electrophoresis, 8 HPLC/MS/ MS, 9 LC-MS/MS, 10 and ic-ELISA. 5 Although the analytical performance in aforementioned technologies is satisfactory, specialized staff, lengthy procedures, and cumbersome pretreatment fail to satisfy the ever-increasing requirements of on-site surveillance concerns, especially for the emergency cases in poor economies and developing countries.…”
Section: Introductionmentioning
confidence: 99%
“…According to the literature survey, some techniques were reported for the estimation of VANH in different matrices including spectrophotometric [10][11][12], spectrofluorimetric [13][14][15], electrochemical [7,16,17], HPLC [18][19][20][21][22][23][24][25][26], LC-MS/MS [8,[27][28][29][30][31][32][33][34][35][36][37], capillary electrophoresis [38][39][40][41], radioimmunoassay and ELISA-based immunoassay techniques [42][43][44]. VANH has native fluorescence at 335 nm after excitation at 268 nm according to the previous study [14].…”
Section: Introductionmentioning
confidence: 99%
“…According to the literature survey, some techniques were reported for the estimation of VANH in different matrices including spectrophotometric [4][5][6], spectro uorimetric [7][8][9], electrochemical [10][11][12], HPLC [13][14][15][16][17][18][19][20][21], LC-MS/MS [22][23][24][25][26][27][28][29][30][31][32][33], capillary electrophoresis [34][35][36][37], radioimmunoassay and ELISA-based immunoassay techniques [38][39][40]. VANH has native uorescence at 335 nm after excitation at 268 nm according to this study [8].…”
Section: Introductionmentioning
confidence: 99%