Toxicity Tests

Paget, Graham; Barnes, J. M.

doi:10.1016/b978-1-4832-2845-7.50012-8

Cited by 238 publications

(171 citation statements)

References 0 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…In the literature Siddha Vaithiya Thirattu, the human intended dosage for AC was recommended as 130 mg twice a day (260 mg/day) (Kuppusamy, 1998). On the basis of body surface area conversion against human dose, 24 mg/kg/day dosage of AC was calculated for rat (Paget and Barnes, 1964). In the present study, three doses of AC of 12 mg/kg/day (Low dose), 24 mg/kg/day (Intermittent dose) and 48 mg/kg/day (High dose) were selected for administration.…”

Section: Sub-acute Toxicity Studymentioning

confidence: 99%

Toxicological Study of a Siddha Sastric Formulation Arumuga Chendhuram in Rat Model

Ramamurthy¹,

Vembu²,

Manickavasakam³

2016

J App Pharm Sci

View full text Add to dashboard Cite

The study was aimed to profile the acute and sub-acute oral toxicity of a herbo-metallic drug Arumuga Chendhuram (AC). AC was prepared classically and analyzed for elemental composition using X-ray Fluorescence. Acute oral toxicity study was done on female rats at AC 2 g/kg as single administration following OECD guideline 423. For sub acute toxicity study, AC was administered orally for 28 consecutive days suspended in vehicle (Honey + distilled water) to rats following OECD guideline 407. Four groups was allotted (10 rats/group), control received vehicle; the other received AC at 12, 24 & 48 mg/kg/day respectively. Mortality and abnormal clinical signs were observed. Haematological and biochemical parameters were analyzed using auto analyzer with standard kits and ANOVA-Dunnett test was performed for significant analyses. Gross necropsy and histopathology studies using H&E stain were done on major organs. Mercury and Lead were found more than the WHO permissible limits in XRF study. LD50 was found more than 2 g/kg. NoObserved-Adverse-Effect level of AC was seen at 24 mg/kg in 28 days of treatment. No abnormal findings were noted in high dose group organs. Administration of AC at its human therapeutic dose of 260 mg/kg in rat (24 mg/kg) is safe.

show abstract

Section: Sub-acute Toxicity Studymentioning

confidence: 99%

Toxicological Study of a Siddha Sastric Formulation Arumuga Chendhuram in Rat Model

Ramamurthy¹,

Vembu²,

Manickavasakam³

2016

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…To under each peak and computed statistically by non-parametric test (p < 0.05). The test drug Trikatu was administered orally to CF rat at acute (2,000 mg/kg body weight as a single dose) and sub-acute doses at 5, 50 and 300 mg/kg body weight once daily for 28 days with the objective of determining the safety limit in our experimental condition so that data can be extrapolated to a human patient (Paget and Barnes, 1964). No mortality or morbidity was observed throughout the experimental period.…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats

et al. 2009

View full text Add to dashboard Cite

-Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety by the experimental animals (both male and female) and no changes were observed in mortality, morbidity, gross pathology, gain in weight, vital organ weight, hematological (total white blood cells (WBC) and red blood cells (RBC) count), biochemical parameters such as serum creatinine, serum glutamate oxaloa--sue biochemical parameters such as reduced glutathione and malonaldehyde content as oxidative stress markers. In sub-acute experiment, Trikatu was administered at 5, 50 and 300 mg/kg body weight once -300 mg/kg body weight, increase in SGPT activity at 50 mg/kg body weight and decrease in WBC count at 300 mg/kg body weight on 28 th day post treatment.

show abstract

“…The doses for rats used were based upon the human dose after conversion to that of rat according to Paget and Barnes conversion tables [14].…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Ethamsylate Protects Against the Carbon Tetrachloride-Induced Liver Damage in Rats

Abdel-Salam¹

2017

JDMDC

View full text Add to dashboard Cite

Ethamsylate is a synthetic haemostatic drug used for controlling capillary bleeding. In this study, the effect of ethamsylate on liver injury induced by acute carbon tetrachloride (CCl 4 ) administration in rats was investigated. Ethamsylate (45, 90 or 180 mg/kg) was given once daily orally simultaneously with CCl 4 and continued for 1 week thereafter. The extent of liver damage was determined by measuring serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) as well as by liver histopathology. Ethamsylate given at the above doses conferred significant hepatic protection against the CCl 4 -induced hepatotoxicity. It reduced serum ALT activities by 44.8%-70.9%, AST by 46.1%-51.4%, and ALP by 30.7%-48.5%, respectively, compared to the CCl 4 control group. Ethamsylate given at 90 mg/kg to CCl 4 -treated rats resulted in the preservation of the normal architecture of the liver tissue and no lymphocytic infiltration. These data indicate a beneficial effect for ethamsylate in the CCl 4 model of hepatotoxicity. Keywords:

show abstract

Toxicity Tests

Cited by 238 publications

References 0 publications

Toxicological Study of a Siddha Sastric Formulation Arumuga Chendhuram in Rat Model

Toxicological Study of a Siddha Sastric Formulation Arumuga Chendhuram in Rat Model

Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats

Ethamsylate Protects Against the Carbon Tetrachloride-Induced Liver Damage in Rats

Contact Info

Product

Resources

About