Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems

Omidi, Yadollah; Kafil, Vala; Barar, Jaleh

doi:10.5772/19035

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Polymeric Gene Delivery Nanosystems1

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Cited by 3 publications

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“…Cationic polymers (e.g., linear and branched polyethyleneimine (l-PEI and b-PEI), poly(L-lysine), and polyamidoamine (PAMAM) dendrimers) can condense the nucleic acids forming polyplexes as either uni-molecular or multi-molecular complexes. Unfortunately, similar to CLs, cationic polymers can also induce intrinsic toxicogenomics [86] and cytotoxicity [16]. To achieve efficient targetspecific gene transfer, these polymers can covalently be modified by conjugating targeting ligands.…”

Section: Polymeric Gene Delivery Nanosystemsmentioning

confidence: 99%