Toxicologic and Carcinogenic Evaluation of Fenvalerate in the B6C3F1 Mouse

Parker, C. M.; McCULLOUCH, C.B.; Gellatly, J.B.M.; JOHNSTON, C.D.

doi:10.1093/toxsci/3.2.114

Cited by 4 publications

(3 citation statements)

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“…Body weight was significantly decreased in male and female mice in fenvalerate toxicity for 2 years (Parker et al, 1983). However Varshneya et al (1992) did not find any effect of cypermethrin in rats on body weight gain.…”

Section: Discussion Body Weightmentioning

confidence: 95%

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Mondal¹,

Mukhopadhayay²,

Kumar³

et al. 2015

Adv. Anim. Vet. Sci.

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| A chronic study was conducted on Sprague Dawley (SD) rats for 13 weeks using 48 rats in four groups each having 12 animals. Group I was control. Group II, III and IV were treatment groups receiving acetamiprid in distilled water in the amount of 5mg/kg, 20mg/kg and 40mg/kg, respectively. Body weight gain and feed consumption was decreased. There was lymphocytopenea in acetamiprid treated animal. Liver and kidney marker enzymes and analyte were altered compared to control after 13 weeks of acetamiprid exposure. This study concluded that acetamiprid, used even in this dose range could cause a significant effect on hematobiochemical profile.

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Section: Discussion Body Weightmentioning

confidence: 95%

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Mondal¹,

Mukhopadhayay²,

Kumar³

et al. 2015

Adv. Anim. Vet. Sci.

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“…Insecticidal activity is enhanced as tralomethrin is debrominated to deltamethrin and tralocythrin is debrominated to cypermethrin (Cole et al 1982). Microgranulomatous lesions in mouse liver, lymph nodes, and spleen were shown to be induced by high doses of fenvalerate in 2-yr feeding studies (Parker et al 1983;Okuno et al 1986). A cholesterol conjugate of the chlorophenyl isovaleric acid (CPIA) moiety of fenvalerate has been shown to be responsible for these changes following oral exposure to the 2R,rxS isomer of fenvalerate ).…”

Section: Biotransformationmentioning

confidence: 99%

Comparative Toxicology of the Pyrethroid Insecticides

Bradbury¹,

Coats

1989

Reviews of Environmental Contamination and Toxicology

278

142

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“…However, over a short-term exposure (30 days), fenvaleric acid II is bioaccumulated in rat liver and kidney (Misra and Sharma, 1997). No chronic toxicity and no carcinogenic effects were observed in long-term exposure studies in mice (Parker et al, 1983;Cabral and Galendo, 1990) and rats (Parker et al, 1984). However, high fenvalerate concentrations induce microgranulomas in the liver, spleen, and lymph node in both rats and mice (Cabral and Galendo, 1990;Okuno et al, 1986).…”

mentioning

confidence: 99%

Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

Morisseau

Derbel

Lane

et al. 1999

Toxicological Sciences

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Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.

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Toxicologic and Carcinogenic Evaluation of Fenvalerate in the B6C3F1 Mouse

Cited by 4 publications

References 0 publications

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Comparative Toxicology of the Pyrethroid Insecticides

Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

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