Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Mondal, Samiran; Mukhopadhayay, S. K.; Kumar, Sanjit; Mandal, Partha Sarathi; Pradhan, Saktipada; Biswas, Sreerupa; Purohit, Kamal

doi:10.14737/journal.aavs/2015/3.7.384.394

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Our results showed a significant increase in bilirubin, a result of hemoglobin degradation in mice treated with acetamiprid ( Table ) . Our findings were in line with those reported by Mondal et al …”

Section: Resultssupporting

confidence: 93%

“…ACT treated mice showed normocytic normochromic anemia as their MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin content) and MCHC (mean corpuscular concentration in hemoglobin) values did not significantly differ from controls ( Table ). Our findings were similar to previous researches using different types of xenobiotics, and were reinforced by many reports concerning acetamiprid exposure …”

Section: Resultssupporting

confidence: 92%

“…In fact, the increase of reticulocytes rate translates the hyperfunction of bone marrow to regenerate lost blood cells and compensate the loss of hemoglobin . This increase was accompanied by an unchanged platelet count, which is in agreement with Mondal ’s study ( Table ) …”

Section: Resultssupporting

confidence: 91%

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HPLC‐DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes

Chelly

Salah

et al. 2019

Chemistry & Biodiversity

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The present study was performed to assess the HPLC-DAD analysis as well as antioxidant and protective effects of Tunisian Rhanterium suaveolens (Rs) against acetamiprid (ACT) induced oxidative stress on mice erythrocytes. The in vitro assays showed that the methanolic extract of Rs has an impressive antioxidant effect proved by testing the total antioxidant and scavenging activities using BCB, DPPH and ABTS assays, respectively. Moreover, qualitative and quantitative analysis using HPLC-DAD revealed the richness of Rs in polyphenols where p-Coumaric, Apigenin-7-glucoside and Ferulic acid were detected as the most abundant polyphenols. In the in vivo experiment, ACT, used as a toxicity model, was given to mice at a dose of 20 mg/kg. The latter was the origin of hemolytic anemia characterized by a significant decrease in red blood cells, hemoglobin and hematocrit levels and an increase in bilirubin, LDH, osmotic fragility, reticulocytes and white blood cells number. Characteristic erythrocyte morphological alterations were also determined as spherocytosis, schistocytosis and dacryocystitis. The oxidative status of ACT-treated mice was also altered manifested by a significant increase in MDA and GSH levels and a decrease in SOD, CAT and GPx activities. When receiving the Rs methanolic extract at a dose of 300 mg/kg, all the parameters cited above were restored in mice. These remarkable corrections could only confirm the important antioxidant effect and the noticeable protective properties that possess Rs owing to its broad range of secondary bioactive metabolites.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 92%

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HPLC‐DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes

Chelly

Salah

et al. 2019

Chemistry & Biodiversity

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“…The plasma creatinine level in all treatment groups was significantly decreased compared to control group. Acetamiprid reportedly increases the creatinine level after 20 and 40 mg/kg treatment for 13 weeks (Mondal et al, 2015). Thirty mg/kg acetamiprid treatment for 35 days increased the urea and creatinine plasma levels and decreased the plasma Figure 2.…”

Section: Discussionmentioning

confidence: 92%

Toxic effects of subchronic oral acetamiprid exposure in rats

et al. 2019

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Acetamiprid, a selective agonist of type-2 nicotinic acetylcholine receptors, is one of the most widely used neonicotinoids. The hepato- and nephrotoxic potential of acetamiprid has not been clarified although it is known to be toxic to other several organ systems, including the nervous, respiratory and immune systems. The present study aimed to investigate acetamiprid liver and kidney toxicity in male rats after a 90-day subchronic exposure to 12.5, 25 and 35 mg/kg. The biochemical and oxidative damage parameters were determined in the plasma and tissue samples as well as histopathological evaluation in the liver and kidney tissues. Acetamiprid caused oxidative damage and affected the liver, denoted by injury markers including the levels of cholesterol, and alanine aminotransferase and aspartate aminotransferase enzymes. There was also a decrease in plasma urea, uric acid and creatinine levels, all of which might result from liver injury. Additionally, acetamiprid was more toxic to the liver than the kidney according to the histopathological examinations. In conclusion, acetamiprid exhibited hepatotoxic potential at all treatment doses on male Sprague Dawley rats.

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“…Our results are in agreement with Lopez-Antia et al (2013) who attributed such decrease in TP, albumin, globulin levels to increased protein catabolism. Decreased levels of globulin indicating that the immune competency of the animals will be easily compromised by IMI (Mondal et al, 2015). While their values significantly increased in GAE/ IMI (protected) and IMI/GAE (treated) groups than IMI group with a more significant increase in IMI+GAE (combination) group however all treatments did not reach control values.…”

Section: Ne Usmentioning

confidence: 95%

Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

Farag¹,

Fotoh²,

EL-Sayed³

et al. 2019

Adv. Anim. Vet. Sci.

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The current study was conducted for evaluation of the hepatotoxic effect of Imidacloprid (IMI) in rats and to assess the modulatory role of Zingiber officinale Roscoe, ginger aqueous extract (GAE), against such effect. Sixty mature male rats (Rattus norvegicus) were utilized and divided into six groups (10 each); group 1 was negative control received 0.1 ml of distilled water, group 2 was positive control which received 1ml of GAE, group 3 administered with 0.1 ml of IMI, group 4:administered 1ml of GAE for 2 weeks followed by administration of 0.1ml of IMI (served as protected group), group 5 administered with 0.1 ml of IMI then 1ml of GAE for 2 weeks (served as treated group) and the last group simultaneously administered with 0.1ml of IMI and 1ml of GAE (served as combination group). Oral dosing of IMI and GAE was triple weekly (day after day) and the experimental period was three months for all groups. IMI exposure caused significant increase in alanine aminotransferase (ALT), aspartate amino transferase (AST) levels, significant decrease in total proteins, albumin and globulins in serum, IMI upregulates interleukin 6 (IL 6), tumor necrosis factorα (TNF-α) and toll like receptor 2 (TLR2) genes in the liver of rats associated with intense immuno positive reactivity of TLR2 and TNF α in the liver of IMI-treated group. Histopathological examination revealed significant alterations in the liver tissue of IMI-treated group, such as disorganization of hepatic cords replaced by mononuclear cells which surrounded by lymphocytes and mild congestion of blood vessels was also seen. In conclusion, the IMI hepatotoxic effect could be modulated by the use of GAE.

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Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats

Cited by 8 publications

References 17 publications

HPLC‐DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes

HPLC‐DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes

Toxic effects of subchronic oral acetamiprid exposure in rats

Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

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