2021
DOI: 10.1007/s11356-021-16407-8
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Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats

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Cited by 8 publications
(5 citation statements)
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“…Additionally, Cd induced a remarkable reduction in the total body weight of rats. However, the relative weight of the liver and kidneys were not significantly altered by different treatments, Similar findings were observed by other authors [71,72]. C. vulgaris in our present study could improve the altered hematological parameters and normalize the Cd-reducing effect on body weight.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Additionally, Cd induced a remarkable reduction in the total body weight of rats. However, the relative weight of the liver and kidneys were not significantly altered by different treatments, Similar findings were observed by other authors [71,72]. C. vulgaris in our present study could improve the altered hematological parameters and normalize the Cd-reducing effect on body weight.…”
Section: Discussionsupporting
confidence: 92%
“…In our present study, the administration of CdCl 2 significantly decreased Hb, PVC, WBC count, and lymphocytes (which are immune cells fundamental in cellular and humoral immunity. In the blood, they represent 20 to 45% of WBC), and this agreed with earlier studies which reported that CdCl 2 could alter the hematological indices [ 70 , 71 ]. Additionally, Cd induced a remarkable reduction in the total body weight of rats.…”
Section: Discussionsupporting
confidence: 92%
“…The combination of PFOS (100 ng/mL) and BPA (10 ng/mL) for 14 days during the cardiac differentiation period increased cardiomyocyte size and collagen content compared with PFOS or BPA exposure alone [280]. Moreover, after exposure of male Wistar albino rats to BPA (5 mg/kg), lead (Pb) (100 ppm), endosulfan (0.61 mg/kg), BPA and Pb, BPA and endosulfan, Pb and endosulfan, and all three (BPA + Pb + endosulfan) for 65 days, the BPA + Pb + endosulfan combination group exhibited more severe histopathological changes in the liver and kidney tissues; elevated malondialdehyde in the liver; decreased superoxide dismutase activity in the kidney tissue; and increased serum ALT, BUN, and creatinine levels compared to the control group [281]. In addition, co-exposure to BPA (10 µg/kg) and arsenic (10 ppb) activated the genes involved in glycogenesis, glucogenesis, and fatty acid oxidation in the liver [282].…”
Section: Factors Influencing Bpa-mediated Disorders In Cardiovascular...mentioning
confidence: 88%
“…A study in rats showed that proteinuria and glomerular damage were associated with increased lipid peroxidation and decreased levels of the antioxidants, glutathione and superoxide dismutase. BPA is known to directly act on kidney mitochondria to cause oxidative stress and mitochondrial dysfunction, resulting in subsequent damage to the whole organ [ 153 , 154 , 155 , 156 ]. Longer exposure times involve transcriptional responses of immune-related genes, potentially due to BPA-related oxidative stress in inducing inflammatory responses in macrophages [ 157 , 158 , 159 ].…”
Section: Bisphenol Amentioning
confidence: 99%