Toxicological Assessment of Microcystin‐LR to Zebrafish (<i>Danio rerio</i>) Using Metabolomics

Yoon, Dahye; Choi, Hong-Seok; Noh, Hyeonkyung; Ok, Young Jun; Oh, Sangah; Ma, Seohee; Yoon, Changshin; Kim, Suhkmann

doi:10.1002/bkcs.11112

Cited by 8 publications

(4 citation statements)

References 40 publications

(54 reference statements)

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“…The dissolving mechanism was proposed and relative photograph of dissolving all kinds of metal source by following in Fig. 17 Subsequently, the process was extended to thiol-amine process, which are the "alkahest" solvent systems [141][142][143][144][145][146] , including dissolving metal element [141][142][143][144] , metal oxides [145] , metal salts [146,147] , all of which have achieved high quality CZTS thin film. It was noted that in this "alkahest" solvent systems, selenium powder was also introduced to the uniform solution for selenizing in situ [146] .…”

Section: Non-hydrazine-based Molecule Precursor Solutionmentioning

confidence: 99%

“…It was noted that in this "alkahest" solvent systems, selenium powder was also introduced to the uniform solution for selenizing in situ [146] . In addition, SnS 2 can be dissolved in the solution of (NH 4 ) 2 S and (N 2 H 5 ) 2 S, forming soluble Sn 2 S 6 2 − ions [126,147] . S x 2 − ions were formed by the reaction of elemental sulfur with organic amines [148] .…”

Section: Non-hydrazine-based Molecule Precursor Solutionmentioning

confidence: 99%

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Path towards high-efficient kesterite solar cells

Wang

Zhao

Zhang

et al. 2018

Journal of Energy Chemistry

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Kesterite structure semiconductor Cu 2 ZnSn(S,Se) 4 is one of the most promising candidate as a light absorber material to overtake the next generation of thin film solar cells, owing to its low cost, non-toxic, and earth abundant source materials. The Shockley-Queisser limit of the single junction Cu 2 ZnSn(S,Se) 4 solar cell is over 30%, signifying a large potential of this family of solar cells. In the past years, with the development of synthesis techniques, Cu 2 ZnSn(S,Se) 4 solar cells have attracted considerable attention and the power conversion efficiency of Cu 2 ZnSn(S,Se) 4 solar cell has experienced a rapid progress. Presently, the certified champion efficiency of CZTSSe solar cells has reached to 12.6%, which is far below the efficiency of Cu(In,Ga)Se 2 solar cell. In this review, the developments of Cu 2 ZnSn(S,Se) 4 solar cells in recent years are briefly reviewed. Then the fundamental understanding of Cu 2 ZnSn(S,Se) 4 solar cells is introduced, including materials and device structure, as well as the band alignment of hetero-junction and their impacts on device performance. After that, we mainly review the progress and achievements in the preparation processes, through vacuum and non-vacuum based processes. Finally, we outline the challenges and perspectives of this promising solar cell.

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Section: Non-hydrazine-based Molecule Precursor Solutionmentioning

confidence: 99%

Section: Non-hydrazine-based Molecule Precursor Solutionmentioning

confidence: 99%

Path towards high-efficient kesterite solar cells

Wang

Zhao

Zhang

et al. 2018

Journal of Energy Chemistry

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“…Таким образом, сбор, предварительная обработка и подготовка биологических образцов критически важны для получения репрезентативного состояния изучаемой системы. Сбор и хранение проб (преаналитика) являются ключевыми шагами для обеспечения репрезентативности [6].…”

Section: результаты и обсуждениеunclassified

The promise of metabolomic approaches in toxicological studies

Ponamarev

2022

jour

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Metabolomics as a progressive tool for pharmaco-toxicological research is gradually proving its value in toxicity according to the strategy for making a chronological assessment of new and developing diseases. The aim of the new approaches is to use the most complete statistics to summarize information protocols using food safety protocol approaches, and to reduce the number of cases in biomodeling studies and time. The term "metabolomics" refers to the measurement of small molecules, which are the particular probability of biological systems (cells, tissues, organisms, etc.) at a particular point in time. The main purpose of the review is to give an idea of planning and a number of metabolic studies to use an arsenal of methodological approaches, incl. in arbitration toxicology.The collection and analysis of scientific publications was carried out according to the recommendation of H. Snyder for writing review articles. In Russian, they are presented in various bibliographic databases (Elibrary, Pubmed, Scopus (Elsevier), Web of Science (Clarivate)) later publications.The need for a toxicological assessment of new cases identified highlights metabolomics as the most promising method for testing the safety of pharmaceutical substances. Metabolomic studies have a high potential to detect biomarkers that indicate the toxicity of natural compounds.

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“…We selected metabolomics as a novel approach to identifying changes in the metabolic profiles. Metabolites are the end products in vivo that are close to the phenotype [6]. Our hypothesis was that the metabolic profiles may vary in predictable ways according to cultivation region, ginseng’s age, and other external factors.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics for Age Discrimination of Ginseng Using a Multiplex Approach to HR-MAS NMR Spectroscopy, UPLC–QTOF/MS, and GC × GC–TOF/MS

Yoon

Choi

et al. 2019

Molecules

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(1) Background: The ability to determine the age of ginseng is very important because the price of ginseng depends on the cultivation period. Since morphological observation is subjective, a new scientific and systematic method for determining the age of ginseng is required. (2) Methods: Three techniques were used for a metabolomics approach. High-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy was used to analyze powdered ginseng samples without extraction. Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) and gas chromatography quadrupole time-of-fight mass spectrometry (GC-TOF/MS) were used to analyze the extracts of 4-, 5-, and 6-year-old ginseng. (3) Results: A metabolomics approach has the potential to discriminate the age of ginseng. Among the primary metabolites detected from NMR spectroscopy, the levels of fumarate and choline showed moderate prediction with an area under the curve (AUC) value of more than 0.7. As a result of UPLC-QTOF/MS-based profiling, 61 metabolites referring to the VIP (variable importance in the projection) score contributed to discriminating the age of ginseng. The results of GC×GC-TOF/MS showed clear discrimination of 4-, 5-, and 6-year-old ginseng using orthogonal partial least-squares discriminant analysis (OPLS-DA) to 100% of the discrimination rate. The results of receiver operating characteristic (ROC) analysis, 16 metabolites between 4- and 5-year-old ginseng, and 18 metabolites between 5- and 6-year-old ginseng contributed to age discrimination in all regions. (4) Conclusions: These results showed that metabolic profiling and multivariate statistical analyses can distinguish the age of ginseng. Especially, it is meaningful that ginseng samples from different areas had the same metabolites for age discrimination. In future studies, it will be necessary to identify the unknown variables and to collaboratively study with other fields the biochemistry of aging in ginseng.

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Toxicological Assessment of Microcystin‐LR to Zebrafish (Danio rerio) Using Metabolomics

Cited by 8 publications

References 40 publications

Path towards high-efficient kesterite solar cells

Path towards high-efficient kesterite solar cells

The promise of metabolomic approaches in toxicological studies

Metabolomics for Age Discrimination of Ginseng Using a Multiplex Approach to HR-MAS NMR Spectroscopy, UPLC–QTOF/MS, and GC × GC–TOF/MS

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