Toxicological effects of dietary arsenic exposure in lake whitefish (Coregonus clupeaformis)

Pedlar, R.M; Ptashynski, M.D; Evans, R. E.; Klaverkamp, J. F.

doi:10.1016/s0166-445x(01)00198-9

Cited by 74 publications

(35 citation statements)

References 63 publications

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“…31,32 Therefore, we asked whether trolox could affect As 2 O 3 -associated hepatocellular damage in vivo. Mice were randomly divided into groups of five mice and treated with two doses of trolox and a dose of As 2 O 3 (7.5 mg/kg) reported to be moderately toxic.…”

Section: Trolox Significantly Enhances As 2 O 3 -Induced Apoptosis Ofmentioning

confidence: 99%

Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity

et al. 2007

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Arsenic trioxide (As 2 O 3 ) is an effective therapy in acute promyelocytic leukemia (APL), but its use in other malignancies is limited by the higher concentrations required to induce apoptosis. We have reported that trolox, an analogue of a-tocopherol, increases As 2 O 3 -mediated apoptosis in a variety of APL, myeloma and breast cancer cell lines, while nonmalignant cells may be protected. In the present study, we extended previous results to show that trolox increases As 2 O 3 -mediated apoptosis in the P388 lymphoma cell line in vitro, as evidenced by decrease of mitochondrial membrane potential and release of cytochrome c. We then sought to determine whether this combination can enhance antitumor effects while protecting normal cells in vivo. In BDF 1 mice, trolox treatment decreased As 2 O 3 -induced hepatomegaly, markers of oxidative stress and hepatocellular damage. In P388 tumor-bearing mice, As 2 O 3 treatment prolonged survival, and the addition of trolox provided a further significant increase in lifespan. In addition, the combination of As 2 O 3 and trolox inhibited metastatic spread, and protected the tumor-bearing mice from As 2 O 3 liver toxicity. Our results suggest, for the first time, that trolox might prevent some of the clinical manifestations of As 2 O 3 -related toxicity while increasing its pro-apoptotic capacity and clinical efficacy in hematological malignancies.

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Section: Trolox Significantly Enhances As 2 O 3 -Induced Apoptosis Ofmentioning

confidence: 99%

Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity

et al. 2007

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“…Decreased feed intake and weight gain have also been previously reported in other models, i.e. broilers, and fish (Vodela et al 1997;Pedlar et al 2002). In addition to changes in food intake/weight gain, emaciation and lacrimation in arsenicexposed Mallard ducklings has been documented (Hoffman et al 1992).…”

Section: Discussionmentioning

confidence: 64%

Immunosuppressive effects of arsenic in broiler chicks exposed to Newcastle disease virus

Sattar

Khan

Hussain

et al. 2016

Journal of Immunotoxicology

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To assess the effects of prolonged exposure to arsenic (As, as arsenate) on host immune competence overall and resistance to Newcastle disease (ND) viral infection in particular, a study was carried out in broiler chicks. At 7 days of age, chicks were assigned to groups that would undergo varying vaccination, challenge, and/or As exposures; Group 1 was a control; Group 2 was to receive Newcastle disease virus (NDV) only; two groups (Groups 3, 4) were to be given As daily (50 mg/kg, by gavage) from Days 7-35 of the experiment. All groups underwent normal vaccination on Days 5, 23, and 32 against live NDV (B1 type, LaSota strain); two groups (Groups 2, 4) were challenged with field-isolated NDV at Day 24. At Days 14, 21, 28, and 35 of age, subsets of chicks in each group were evaluated. The results showed feed intake and weight gain were lower in As-treated and NDV-challenged chicks. In As-treated chicks, absolute and relative spleen weights were significantly greater, whereas those of the thymus significantly lower, over the entire 35-day period. Effects on bursa weights (absolute, relative) were only significantly reduced through Day 21. Antibody titers against ND were significantly reduced (vs. control) over the whole 35 days in birds that received As alone, but only significantly depressed through the first 21 days in birds that received As þ NDV; thereafter, titers were significantly greater (in parallel with effects in birds that received NDV alone). In contrast, antibody responses to T-dependent antigen (Sheep red blood cells [SRBC]) were significantly lower in As only-and As þ NDV-treated chicks throughout the study period. Among birds exposed to As (alone or with NDV), in situ phagocytic activity was elevated and cutaneous sensitivity responses decreased during the period from Day 28 to Day 35. NDV alone had spurious effects on phagocytic activity but did cause significant reductions in cutaneous sensitivity responses. It was concluded that arsenic decreased immunity in broiler chicks, thereby making them prone to ND. ARTICLE HISTORY

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“…The liver is the main metabolic fish organ and it plays an important role in the uptake, accumulation, biotransformation and excretion of toxic elements (Pedlar et al 2002). In relation to As, several studies have reported liver fibrosis, hepatocellular damage, cell edema, focal necrosis areas in addition to hepatocellular carcinoma (Liu et al 2001, ATSDR 2002, Datta et al 2009).…”

Section: Introductionmentioning

confidence: 99%

HISTOPATHOLOGICAL CHANGES IN LIVER AND GILLS OF Odontesthes bonariensis INHABITING A LAKE WITH HIGH CONCENTRATIONS OF ARSENIC AND FLUORIDE (CHASICÓ LAKE, BUENOS AIRES PROVINCE)

Puntoriero¹,

Cirelli²,

Volpedo³

2018

Rev. Int. Contam. Ambie.

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Water bodies in the Chaco-Pampean plain contain arsenic (As) and fluoride (F -) occurring naturally. Chasicó Lake, located in the southwest of Buenos Aires Province, has high concentrations of both elements (As, 0.05-0.41 mg/L; F -, 6.74-8.54 mg/L). Fish can be considered as indicators of environmental pollution. The aim of this study was to analyze whether the presence of high concentrations of As and F -found in the liver and gills of Odonthestes bonariensis could be associated to histological changes found in these tissues. Fish were sampled from different locations of the lake. Tissue samples (liver and gills) were subdivided and subjected to an acid digestion to determine As and to an alkaline digestion to determine F -. Morphological changes were assessed using routine histological techniques. As concentrations in the liver were higher than in the gills, while the gills showed higher F -concentrations. The histological examination of the liver and gills showed alterations that could correspond to the effects of the high As and F -concentrations found in these tissues. The toxicity of these elements is due to oxidative stress. Silverside is one commercially relevant fish in Buenos Aires and a key species in the food chain in the region. Therefore, further histopathological studies are relevant to guarantee this fish's health and safety for human consumption.Palabras clave: histopatología, elementos traza, pejerrey, Argentina RESUMEN Los cuerpos de agua de la llanura Chaco-Pampeana contienen arsénico (As) y fluoruro (F -) cuyo origen es natural. El Lago Chasicó, ubicado en el sudoeste bonaerense, presenta elevadas concentraciones de ambos elementos (As: 0.05-0.41 mg/L; F -: 6.74-8.54 mg/L). Los peces pueden considerarse como indicadores de contaminación ambiental. El objetivo de este estudio fue analizar si la presencia de altas concentraciones de As y F -halladas en hígado y branquias de Odonthestes bonariensis pudiera estar asociada con los cambios histológicos encontrados en estos tejidos. Los peces fueron colectados en diferentes localidades del lago. Se subdividieron muestras de tejidos (hígado y branquias) y se sometieron a una digestión ácida para determinar As y a una digestión Rev. Int. Contam. Ambie. 34 (1) 69-77, 2018 DOI: 10.20937/RICA.2018 M.L. Puntoriero et al. 70alcalina para determinar F -. Los cambios morfológicos se determinaron mediante técnicas histológicas de rutina. En hígado se hallaron concentraciones de As más altas que en branquias, mientras que las branquias mostraron concentraciones de F -más elevadas. El examen histológico del hígado y las branquias mostró alteraciones que podrían corresponder a los efectos de las altas concentraciones de As y F -halladas en esos tejidos. La toxicidad de estos elementos se debe al estrés oxidativo. El pejerrey es uno de los peces comerciales más importantes de Buenos Aires y una de las especies clave de la cadena alimenticia en la región, por lo que resultan relevantes estudios histopatológicos adicionales para asegurar la salud de los ...

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Toxicological effects of dietary arsenic exposure in lake whitefish (Coregonus clupeaformis)

Cited by 74 publications

References 63 publications

Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity

Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity

Immunosuppressive effects of arsenic in broiler chicks exposed to Newcastle disease virus

HISTOPATHOLOGICAL CHANGES IN LIVER AND GILLS OF Odontesthes bonariensis INHABITING A LAKE WITH HIGH CONCENTRATIONS OF ARSENIC AND FLUORIDE (CHASICÓ LAKE, BUENOS AIRES PROVINCE)

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