Toxicological evaluation of Nerium oleander on isolated preparations

Abstract

In uitro toxicological evaluation of Nerium oleander was carried out using different isolated preparations. The methanolic leaf extract potentiated both spontaneous and electrically evoked contractions of vas deferens of rats and guinea-pig ileum in a concentration dependent manner. The effect was not antagonized by the adrenergic blocker, tolazoliie. The extract inhibited electrically stimulated neurogenic twitch responses of rat phrenic nerve diaphragm preparation. The dose dependent inhibition of twitch response in this preparation could not be reversed by the anticholinesterase drug, neostigmine. The extract evoked a persistent depolarizing effect on the phrenic nerve diaphragm preparation. The extract exhibited its most potent action on the isolated right atrial preparation of rat. It inhibited the rate of spontaneously beating atria in a concentration dependent manner. The negative chronotropic effect was not antagonized either by antimuscarinic drug or adrenergic agonist.

Ethnobotanical and toxicology study of medicinal plants used for the treatment of diabetes in the High Atlas Central of Morocco

“…Leaves Dermal toxicity, digestive toxicity, cardiovascular toxicity (Mazumder et al, 1994;Ajebli et al, 2017) (Jouad et al, 2001;Eddouks et al, 2002;Benkhnigue et al, 2010;Alami et al, 2015;Douira and Zidane, 2015;Barkaoui et al, 2017;Laadim et al, 2017;Mrabti et al, 2019;Skalli et al, 2019;Fouad and Lahcen, 2020;Idm'hand et al, 2020) (Bonet et al, 1999;Zekkour, 2008;Hammiche et al, 2013) (Jouad et al, 2001;Eddouks et al, 2002;Benkhnigue et al, 2010;Bousta et al, 2014;Douira and Zidane, 2015;Laadim et al, 2017;Mrabti et al, 2019;Fouad and Lahcen, 2020;Idm'hand et al, 2020)…”

Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR‐1339‐Induced Hyperlipidemia in Experimental Sprague Dawley Rats

“…Nerium oleander Linn is one such polyphenol-and glycoside-rich evergreen shrub belonging to the Apocynaceae, an important Chinese folk medicine [11]. In early times, it is assumed that all parts of the oleander plant are highly toxic to humans, animals, and certain insects due to the presence of cardiac glycosides mainly nerine and oleandrin at higher concentration [12,13]. Nowadays, apart from its toxicity, an assortment of pharmacological activities such as antinociceptive, anti-in�ammatory, antibacterial, anticancer, CNS depressant activity, antidiabetic, rodenticides, piscicidal, pesticides, insecticides, abortifacients, among others, have been screened and reported in leaves, stems, and roots of Nerium oleander except �owers [14][15][16][17][18].…”