Toxicological Evaluation of the Essential Oil fromMentha longifoliaL. subsp.capensisLeaves in Rats

Abstract

The effects of the essential oil from the leaves of Mentha longifolia L. subsp. capensis on some biochemical parameters of Wistar rats were studied. The oil at 125, 250, 375, and 500 microL/kg of body weight reduced (P < .05) the red blood cells and lymphocytes with no definite pattern on the white blood cells and mean cell volume. The doses significantly increased the neutrophils, monocytes, large unstained cells, liver-body weight ratio, and serum concentrations of cholesterol, triglyceride, high-density lipoprotein-cholesterol, and inorganic phosphate but had no effect on the heart body weight ratio and serum low-density lipoprotein-cholesterol, Na(+), Ca(2+), Cl(-), K(+), creatinine, and uric acid. The oil at 500 microL/kg of body weight also increased the kidney-body weight ratio. In contrast, the oil reduced the serum urea and atherogenic index. The total and conjugated bilirubin, together with the total protein and albumin, in the serum increased only with oil at 125 microL/kg of body weight. The serum alkaline phosphatase activity also increased with no significant change in those of gamma-glutamyl transferase and alanine and aspartate aminotransferase. The results indicate dose- and parameter-specific effect of the essential oil. Although the essential oil from M. longifolia leaves may not predispose to atherosclerosis, it may increase the functional activity of the rat liver at the lowest dose investigated. Therefore, the essential oil from M. longifolia may not be completely "safe" at the doses investigated.

Mentha longifolia protects against acetic-acid induced colitis in rats

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Evaluation of acute and subacute toxicity induced by methanol extract of Terminalia citrina leaves in Sprague Dawley rats

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Haematology and Growth Study of Albino Rats Fed Varying Inclusions of Cooked <i>Canavalia Plagiosperma Piper </i>Seed Meal Based-Diets

“…It can also be used to determine the extent of deleterious effect of foreign compounds, including plant extracts, on the blood of the albino rats [2]. Heamatological parameters can also be used to explain blood relating functions of plant extract or its products [2,23,24].…”

“…Eosinophiles are responsible for allergic reactions and disorders, It increases with allergic conditions and decreases with stress and/or infection [1,2,15]. Neutrophiles is mainly responsible for phagocytosis of pathogenic micro organism during the first few hours after their entry into tissues [1].…”

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