Toxicological overview of a novel strobilurin fungicide, orysastrobin

Ravenzwaay, Bennard van; Akiyama, Mitoshi; Landsiedel, Robert; Kieczka, H.; Cunha, G. Coelho-Palermo; Schneider, Steffen; Kaspers, Uwe; Kaufmann, Wolfgang; Osawa, Masaki

doi:10.1584/jpestics.g06-52

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…) with (2 E )‐ O ‐methoximino acetamide structure and a (3 E ,5 E ,6 E )‐ tris ‐(methoximino) side chain was specifically developed for application in a nursery box of rice seedlings for long‐lasting control of leaf and panicle blast ( Magnaporthe grisea ) and sheath blight ( Thanatephorus cucumeris ) in rice with or without an insecticide partner . The oximino‐acetamide fungicide is systemic, with sufficient intrinsic activity, and its physicochemical properties demonstrate a low lipophilicity and high solubility in water . Finally, the fungicide can be taken up by the roots and translocated acropetally into the rice leafs, with excellent plant selectivity under different environmental conditions.…”

Section: Fungicides For Disease Controlmentioning

confidence: 99%

“…32 The oximino-acetamide fungicide is systemic, with sufficient intrinsic activity, and its physicochemical properties demonstrate a low lipophilicity and high solubility in water. 33 Finally, the fungicide can be taken up by the roots and translocated acropetally into the rice leafs, with excellent plant selectivity under different environmental conditions. During recent years, several strobilurin types have been announced as being developed or launched for the Chinese market by the Shenyang Research Institute of the Chemical Industry (SYRICI).…”

Section: Respiratory Chain (Qo-site/complex Iii) Inhibitorsmentioning

confidence: 99%

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Progress of modern agricultural chemistry and future prospects

2015

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Agriculture is facing an enormous challenge: it must ensure that enough high-quality food is available to meet the needs of a continually growing population. Current and future agronomic production of food, feed, fuel and fibre requires innovative solutions for existing and future challenges, such as climate change, resistance to pests, increased regulatory demands, renewable raw materials or requirements resulting from food chain partnerships. Modern agricultural chemistry has to support farmers to manage these tasks. Today, the so-called 'side effects' of agrochemicals regarding yield and quality are gaining more importance. Agrochemical companies with a strong research and development focus will have the opportunity to shape the future of agriculture by delivering innovative integrated solutions. This review gives a comprehensive overview of the innovative products launched over the past 10 years and describes the progress of modern agricultural chemistry and its future prospects.

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Section: Fungicides For Disease Controlmentioning

confidence: 99%

Section: Respiratory Chain (Qo-site/complex Iii) Inhibitorsmentioning

confidence: 99%

Progress of modern agricultural chemistry and future prospects

2015

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“…HPLC Analysis. Orysastrobin is known to be a moderate polar compound with a log P value of 2.36 (20 °C), but it exhibits low volatility (7 Â 10 À7 mPa, 20 °C), 9 as do other strobilurin fungicides. Therefore, the HPLC operation was conducted with the purpose of identifying the best instrumental conditions.…”

Section: Florisil Column Chromatography a Chromatographic Columnmentioning

confidence: 99%

Simultaneous Determination of Orysastrobin and Its Isomers in Rice Using HPLC-UV and LC-MS/MS

Kwon

Lee

2011

J. Agric. Food Chem.

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Orysastrobin is a new strobilurin-type fungicide to control leaf and panicle blast and sheath blight in rice. An analytical method was developed to determine the residues of orysastrobin and its two isomers, the main metabolite F001 and the major impurity F033, in hulled rice by the use of high-performance liquid chromatography with ultraviolet photometry (HPLC-UV) and liquid chromatography with tandem mass spectrometry (LC-MS/MS). All compounds were extracted with acetone from hulled rice samples. The extract was diluted with saline water, and an extraction step using dichloromethane/n-hexane partition was used to recover analytes from the aqueous phase. An n-hexane/acetonitrile partition and Florisil column chromatography were employed to further remove interfering coextractives prior to instrumental analysis. An octadecylsilyl column was successfully applied to identify orysastrobin and its isomers in sample extracts. Net recovery rates of orysastrobin, F001, and F033 from fortified samples ranged from 80.6 to 114.8% using HPLC-UV and LC-MS/MS. Relative standard deviations for the analytical methods were all <20%, and the quantification limits of the method were in the 0.002-0.02 mg/kg range. The proposed methods were reproducible and sufficiently accurate to evaluate the terminal residue of orysastrobin and its isomers in rice.

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