Toxicological profile for toluene diisocyanate and methylenediphenyl diisocyanate

Williams, Malcolm; Todd, Gabrielle; Pohl, Hana R.; Taylor, Jessilynn; Ingerman, Lisa; Carlson-Lynch, Heather; Hard, Courtney; Citra, Mario

doi:10.15620/cdc58080

Cited by 9 publications

(7 citation statements)

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“…For these reasons, some researchers considered that serum Mn levels seem to be more accurate and reliable as a biomarker to detect the Mn exposure status for it is sensitive to various variations in dietary intake of Mn [38]. Moreover, serum Mn levels have a similar t 1/2 with Mn levels in the tissues ranging between 13 and 37 days, suggesting serum Mn levels and tissues Mn levels seem to be concordant after short-term Mn exposure [39]. Additionally, Mirmohammadi et al [40] demonstrated that there is a straight relationship between indoor air Mn levels and serum Mn levels of the occupational Mn-exposed workers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Chen

Sun

et al. 2019

IJERPH

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Excessive manganese (Mn) exposure may adversely affect the central nervous system, and cause an extrapyramidal disorder known as manganism. The glutamine (Gln)/glutamate (Glu)–γ-aminobutyric acid (GABA) cycle and thyroid hormone system may be involved in Mn-induced neurotoxicity. However, the effect of Mn on the Gln/Glu–GABA cycle in the serum has not been reported. Herein, the present study aimed to investigate the effects of sub-acute Mn exposure on the Gln/Glu–GABA cycle and thyroid hormones levels in the serum of rats, as well as their relationship. The results showed that sub-acute Mn exposure increased serum Mn levels with a correlation coefficient of 0.733. Furthermore, interruption of the Glu/Gln–GABA cycle in serum was found in Mn-exposed rats, as well as thyroid hormone disorder in the serum via increasing serum Glu levels, and decreasing serum Gln, GABA, triiodothyronine (T3) and thyroxine (T4) levels. Additionally, results of partial correlation showed that there was a close relationship between serum Mn levels and the detected indicators accompanied with a positive association between GABA and T3 levels, as well as Gln and T4 levels in the serum of Mn-exposed rats. Unexpectedly, there was no significant correlation between serum Glu and the serum T3 and T4 levels. In conclusion, the results demonstrated that both the Glu/Gln–GABA cycle and thyroid hormone system in the serum may play a potential role in Mn-induced neurotoxicity in rats. Thyroid hormone levels, T3 and T4, have a closer relationship with GABA and Gln levels, respectively, in the serum of rats.

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Section: Discussionmentioning

confidence: 99%

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Chen

Sun

et al. 2019

IJERPH

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“…Manganese (Mn) is an essential trace element required for the proper function of many enzymes critical for human health [ 1 , 2 ]. However, chronic exposure to high levels of Mn has been known to be neurotoxic for nearly two centuries [ 3 , 4 , 5 ] and results in a neurological syndrome known as manganism [ 3 , 4 ].…”

Section: Manganese: a Double-edge Sword—essential Metal And Neurotoxi...mentioning

confidence: 99%

Hereditary Disorders of Manganese Metabolism: Pathophysiology of Childhood-Onset Dystonia-Parkinsonism in SLC39A14 Mutation Carriers and Genetic Animal Models

Rodichkin

Guilarte

2022

IJMS

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Over the last decade, several clinical reports have outlined cases of childhood-onset manganese (Mn)-induced dystonia-parkinsonism, resulting from loss-of-function mutations in the Mn influx transporter gene SLC39A14. These clinical cases have provided a wealth of knowledge on Mn toxicity and homeostasis. However, our current understanding of the underlying neuropathophysiology is severely lacking. The recent availability of Slc39a14 knockout (KO) murine and zebrafish animal models provide a powerful platform to investigate the neurological effects of elevated blood and brain Mn concentrations in vivo. As such, the objective of this review was to organize and summarize the current clinical literature and studies utilizing Slc39a14-KO animal models and assess the validity of the animal models based on the clinical presentation of the disease in human mutation carriers.

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“…This substitution has not been entirely successful given that MMT also has toxic effects [ 24 ]. Biologically, manganese is an essential metal needed for mitochondrial oxidative processes for all living mammals, including humans [ 25 ]. Both, the deficiency and excess of manganese may have detrimental health effects.…”

Section: Short Overview Of Prenatal Exposure To Toxic Environmental P...mentioning

confidence: 99%

Introduction to the Special Issue of IJERPH Entitled “Prenatal Exposure to Environmental Pollutants and Other Stressors: Impacts on Fetal Development, Birth Outcomes, Children’s Health and Beyond”

Röllin

2022

IJERPH

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Toxicological profile for toluene diisocyanate and methylenediphenyl diisocyanate

Cited by 9 publications

References 0 publications

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats

Hereditary Disorders of Manganese Metabolism: Pathophysiology of Childhood-Onset Dystonia-Parkinsonism in SLC39A14 Mutation Carriers and Genetic Animal Models

Introduction to the Special Issue of IJERPH Entitled “Prenatal Exposure to Environmental Pollutants and Other Stressors: Impacts on Fetal Development, Birth Outcomes, Children’s Health and Beyond”

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