Toxicological Studies of N-trans-feruloyl-4-methyldopamine Isolated from Achyranthes ferruginea

Alam, Ahm Khurshid; Islam, Rabiul; Salam, Kazi Abdus; ., Md. Moniruzzaman Manir; Baki, M Abdullahil; Hossain, Md. Motaher; Sadik, Golam

doi:10.3923/pjbs.2006.1052.1055

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…The test sample (Compound 1) was dissolved in such a manner with distilled water and Tween-80 so that each 0.3 ml of the final solution contained 300 μg of the compound 8 . For 14 consecutive days daily each rat for control group A was injected with the vehicle only (0.3ml isotonic solution) and for the experimental group B each rat was injected with 0.3 ml sample solution (containing 300 μg compound).…”

Section: Sample Administrationmentioning

confidence: 99%

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Sub-Acute Toxicity of a Steroidal Glycoside From the Flowers of Alangium Salviifolium Wang

Anjum¹,

Mosaddik²,

Wahed³

et al. 2021

Int. Res. J. Pharm.

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The current study was carried out to investigate the sub-acute toxicity of 3-O--D-glucopyranosyl-(24)-ethylcholesta-5,22,25-triene, a steroidal glycoside isolated from the flowers of Alangium salviifolium Wang on Long Evan’s rat. After intra-peritoneal administration of the compound at a dose of 300 μg/rat/day for 14 consecutive days, no mortality or significant changes in body weight or behavior were observed. The blood samples of the rats were examined for hematological and biochemical parameters which were statistically insignificant when compared to that of the control group. All the vital organs showed normal histopathological architecture (heart, lungs, liver and kidney) in comparison to the control group. This preliminary investigation demonstrate that the compound is safe at dose of 300 μg/rat/day for 14 consecutive days. But acute, sub-chronic and chronic toxicity evaluations as well as clinical trials need to be done.

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Section: Sample Administrationmentioning

confidence: 99%

“…under various condition of the drug. Clinical trial and as well as toxicological studies is mandatory before any drug is used clinically 8 . Toxicological studies are of three types depending on the period of time of drug exposure to animals (viz.…”

Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity of a Steroidal Glycoside From the Flowers of Alangium Salviifolium Wang

Anjum¹,

Mosaddik²,

Wahed³

et al. 2021

Int. Res. J. Pharm.

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show abstract

“…reported that it has antidiarrheal activity (Alam et al., 2002). A subacute toxicity study revealed that the plant has no considerable toxic activity (Alam et al., 2006). All these reported in vitro biological data support the use of the plant as traditional medicine in different diseases.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Reza

Haque

Sarker

et al. 2021

Food Science & Nutrition

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In the present study, the aerial parts of Achyranthes ferruginea underwent investigation of their in vitro antioxidant and free radical‐scavenging activities in cell‐free conditions, their phytoconstituents using gas chromatography‐mass spectrometry (GC‐MS), and their cytotoxic activity in HeLa cells. A. ferruginea was extracted with 80% methanol and successively fractionated with solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), and aqueous (AQF) fractions. GC‐MS analysis revealed that CHF contained ten phytoconstituents, including different forms of octadecanoic acid methyl esters. The total antioxidant and ferric‐reducing antioxidant capacities of the extracts and the standard catechin (CA) were as follows: CA >CHF >PEF >CME (crude methanolic extract) >EAF >AQF, and CA >CHF >EAF >PEF >AQF >CME, respectively. CHF showed the highest DPPH‐free radical‐scavenging activity, with a median inhibitory concentration of 10.5 ± 0.28 µg/ml, which was slightly higher than that of the standard butylated hydroxytoluene (12.0 ± 0.09 µg/ml). In the hydroxyl radical‐scavenging assay, CHF showed identical scavenging activity (9.25 ± 0.73 µg/ml) when compared to CA (10.50 ± 1.06 µg/ml). Moreover, CHF showed strong cytotoxic activity (19.95 ± 1.18 µg/ml) in HeLa cells, which was alike to that of the standards vincristine sulfate and 5‐fluorouracil (15.84 ± 1.64 µg/ml and 12.59 ± 1.75 µg/ml, respectively). The in silico study revealed that identified compounds were significantly linked to the targets of various cancer cells and oxidative enzymes. However, online prediction by SwissADME, admetSAR, and PASS showed that it has drug‐like, nontoxic, and potential pharmacological actions.

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“…These active principles are present in plants in variable amount. 10 Therapeutic value and pharmacological action of the drug are due to the presence of a certain chemical constituents viz., various forms of glycosides and alkaloids, derivatives of carbohydrates, gums, resins, volatile oils, pectin and soon in recent years, a lot of progress has been made owing to the availability of highly sensitive technologies. 11 As a result, chemical composition of certain drug plants was studied upto the molecular level and also the identified chemicals have been screened for pharmaceutical action and mechanism of action which was studied upto the cellular level.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial activity of Asclepias curassavica Ethanol extract

Mohan¹,

Balaji²,

Kadirvelu³

et al. 2019

AJPTR

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The present study was carried out for screening of preliminary phyto-chemical constituents and anti-microbial activity of ethanolic extract of ASCLEPIAS CURASSAVICA. The dried extract obtained by soxhlet extraction was subjected to qualitative phyto-chemical screening for the identification. The anti-microbial activity of A.curassavica flower & plant extract by agar well diffusion method. Our study reveals that B.subtilis & E.coli showed good inhibitory zone in ethanol solvent extract

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Toxicological Studies of N-trans-feruloyl-4-methyldopamine Isolated from Achyranthes ferruginea

Cited by 6 publications

References 8 publications

Sub-Acute Toxicity of a Steroidal Glycoside From the Flowers of Alangium Salviifolium Wang

Sub-Acute Toxicity of a Steroidal Glycoside From the Flowers of Alangium Salviifolium Wang

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Evaluation of antimicrobial activity of Asclepias curassavica Ethanol extract

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