Toxicological study of γ-irradiated aflatoxins using the chicken embryo

REMOVAL OF AFLATOXIN B1 TOXICITY BUT NOT MUTAGENICITY BY 1 MEGARAD GAMMA RADIATION OF PEANUT MEAL

“…There were not toxic or mutagenic effects at doses of 5.0 and 10.0 M-rad. These results are in agreement with the earlier reports cited in the introduction (Ogbadu and Bassir 1979;Aibara and Miyaki 1970). Aibara and Miyaki (1970) found that the destruction rate of aflatoxin B1 by irradiation in liquid depended on the concentration of aflatoxin B1: the higher the concentration, the lower the destruction rate.…”

“…Several laboratories have studied the effect of gamma-irradiation on aflatoxin toxicity (Feuell 1966;Aibara and Miyaki 1970;Ogbadu and Bassir 1979). When Feuell (1966) exposed aflatoxin-contaminated meal to 2.5 megarads (M-rad) of gamma-rays, subsequent feeding trials with ducklings showed that there had been no reduction in the toxicity of the meal.…”

“…Aibara and Miyaki (1970) found that the biological activity of aflatoxin BI was completely lost when aflatoxin BI was irradiated at 40 K-rad in water and 800 K-rad in ethanol. Recently, Ogbadu and Bassir (1979) reported that the mortality rate of chicken embryos due to the injection of irradiated aflatoxin decreased when the dose of gamma-irradiation increased. These data suggest that aflatoxin toxicity may be destroyed by gamma-irradiation in solvent conditions.…”

Irradiation for Mold and Mycotoxin Control: A Review

“…Using the quantitative structure–activity relation, 6 of the 7 radiolytic products were considered less toxic than AFB 1 because these products lost the double bond in the terminal furan ring, which is the determinant for AF toxicity. Using chicken embryos, the lethality of AFs was observed to decrease with increasing gamma‐irradiation doses (Ogbadu and Bassir ).…”

Aflatoxin Contamination in Foods and Feeds: A Special Focus on Africa

“…More intense field trials of such promising plant products and their subsequent formulation into botanical fungicide would be impressive for the continent. Gamma irradiation of AF contaminated foods lowers both the toxicity (Ogbadu and Bassir, 1979) and production (Ogbadu, 1979;Ogbadu, 1980a;Ogbadu, 1981;Ogbadu, 1988) of the toxin in irradiated foods and so this could be a good post harvest, processing and packaging treatment option for African countries if suitable infrastructures are put in place. Hazard Analysis Critical Control Point (HACCP), a proactive management system in which food safety is maintained through the analysis and control of biological, chemical, and physical hazards from raw material production, procurement and handling, to manufacturing, distribution and consumption of the finished product has become a priceless tool for mycotoxin control (FAO, 2003).…”