Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

Kunzmann, Andrea; Andersson, Britta; Thurnherr, Tina; Krug, Harald F.; Scheynius, Annika; Fadeel, Bengt

doi:10.1016/j.bbagen.2010.04.007

Cited by 451 publications

(305 citation statements)

References 165 publications

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“…This process, termed endocytosis, has different features depending on the size and type of the molecule/structure internalized: receptor-independent endocytosis (fluid-based endocytosis and macropinocytosis), and several types of receptor-dependent endocytosis (clathrin-dependent, lipid-raft-independent, lipid raft-dependent/caveolaeindependent, and caveloae-dependent). These endogenous processes are exploited by bacteria and viruses for invading cells, and it is likely that also nanoparticles may enter cells through them, although there are quite conflicting reports as to the exact mechanism(s) mediating cell entry by different nanoparticles [69][70][71][72]. Very likely this is a result of different bio-nano interfaces.…”

Section: The Translocation Concept: Interactions Of Nanomaterials Witmentioning

confidence: 92%

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

et al. 2013

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Abstract:In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research and recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must be studied as biological entities under the appropriate exposure conditions and that this should be implemented in study design and reporting for nanosafety assessment. The implications of the bio-nano interface for nanomaterials fate and behaviour are described in light of four interlinked perspectives: the Coating concept; the Translocation concept; the Signalling concept, and the Kinetics concept. A key conclusion is that nanoparticles cannot be viewed as non-interacting species, but rather must be thought of, and studied as, biological entities, where their interaction with the environment is mediated by the proteins and other biomolecules that adsorb to them, and the key parameter to characterise then becomes the nature, composition and evolution of the bionano interface.

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Section: The Translocation Concept: Interactions Of Nanomaterials Witmentioning

confidence: 92%

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

et al. 2013

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“…These particles may be locally cytotoxic to osteoblasts or can aggregate intravascularly [11]. Especially in the context of the discussion about toxicology and biocompatibility of nanomaterials, there is concern about local toxic or inflammatory systemic side effects of nano grafts [43,113], although there are no evidence based data on the toxicity of nanostructured sHAs at the moment.…”

Section: Degradationmentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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“…With increasingly rigorous controls regarding the use of laboratory animals, there is a need to develop and standardize in vitro tests that can detect the toxicity of medical devices for use in humans, mainly because they should not cause adverse effects to or harm patients [29][30][31][32][33][34][35][36].…”

Section: Methods For In Vitro Cytotoxicity Analysesmentioning

confidence: 99%

Cytotoxicity Tests for Evaluating Medical Devices: An Alert for the Development of Biotechnology Health Products

Vidal¹,

Granjeiro²

2017

JBiSE

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The risks and damages related to the use of products, technologies and services of sanitary interest can be due to defects or manufacturing failures. Certain products already contain a certain degree of risk, which requires strict quality control in their production, distribution and use, as well as in the disposal of their waste in the environment. With continuous development in science and technology, medical devices must undergo intradermal irritation and testing for sensitization, cytotoxicity, and acute systemic toxicity. In health care, biotechnology aims to provide technology-based products or processes related to energy, food, and health, which are capable of stimulating new businesses, expanding exports, integrating the value chain and stimulating new demands for innovative products and processes, taking into account health policies. The present article was prepared by a bibliographical survey of the electronic databases PubMed, Lilacs, and Bireme. Cell culture testing can be successfully employed, as it is reproducible, rapid, sensitive, and financially accessible for performing in vitro toxicity testing. Thus, it has been possible to optimize the development phase of new products by decreasing animal use or even replacing them in certain tests. Some in vitro assays validated by the Organization for Economic Cooperation and Development in the area of health products have already replaced animal testing.

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Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

Cited by 451 publications

References 165 publications

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Cytotoxicity Tests for Evaluating Medical Devices: An Alert for the Development of Biotechnology Health Products

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