Toxicology Updates

Abstract

Like most organic solvents, xylene has irritating effects on the skin, mucous membranes and respiratory tract. It has a narcotic effect on the nervous system, variable effects on the liver and kidneys, and questionable effects on the cardiovascular system and female reproductive system. Xylene was thought to be deleterious to the hemopoietic system, but more recent studies concluded that such effects were due to benzene contamination or inflammation response to xylene injection. The latest evidence indicates that xylenes are not co-carcinogenic, carcinogenic or teratogenic. If maternal toxicity is avoided, xylenes do not have embryotoxic effects.

Xylene Sensor Using Cr-doped Co3O4 Nanoparticles Prepared by Flame Spray Pyrolysis

“…People with clinical or subclinical renal, hepatic, or cardiac disease may be more susceptible to the effects of xylene. Evidence from occupational and case studies indicates that exposure to high levels of xylene might cause renal impairment and some hepatic effects, as well as cardiac manifestations, including tachycardia and ECG abnormalities (Goldie 1960;Hipolito 1980;Morley et al 1970;NIOSH 1975;Von Burg 1982). However, exposure to xylene in these studies was confounded with exposure to other chemical agents.…”