Toxicoproteomic identification of TiO<sub>2</sub>nanoparticle-induced protein expression changes in mouse brain

Jeon, Yu-Mi; Park, Seul-Ki; Lee, Mi-Young

doi:10.1080/19768354.2011.555144

Cited by 24 publications

(8 citation statements)

References 34 publications

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“…As observed in vitro [96][97][98], oxidative stress-related damage with a consequent alteration in the balance between oxidative and antioxidative activities was also reported in in vivo studies [31,73,92,93,95]. Malondiadehyde (MDA) levels increased after intranasal instillations [31,92], intraabdominal injections [93], and intratracheal instillation in mice [73].…”

Section: Carcinogenic Effectsmentioning

confidence: 61%

“…The disturbed homeostasis of trace elements, neurotransmitters, and enzymes in brain may be responsible of the spatial recognition memory impairments reported in treated mice [94]. However, as assessed by a proteomic analysis, proteins of the mouse brain resulted differentially expressed in response to TiO 2 NP treatment even if NPs were not detected in the tissue [95].…”

Section: Carcinogenic Effectsmentioning

confidence: 99%

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Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Iavicoli

Leso

Bergamaschi

2012

Journal of Nanomaterials

215

207

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The essence of nanotechnology is the production of nanoparticles (NPs) with unique physicochemical properties allowing worldwide application in new structures, materials, and devices. The consequently increasing human exposure to NPs has raised concerns regarding their health and safety profiles. Titanium dioxide (TiO2) has been reported to induce adverse pulmonary responses in exposed animals. However, the potential more dangerous biological activities of TiO2NPs compared to their fine-sized counterparts are not fully understood. Therefore, this work is aimed to provide a comprehensive evaluation of the toxic effects induced by TiO2NPs inin vivoexperiments. It is intended to deeply understand the toxicological behaviour of TiO2NPs and to predict potential human health effects. Moreover, it may be an instrument to extrapolate relevant data for human risk evaluation and management and to identify those critical aspects that deserve great attention in future population and epidemiologic research.

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Section: Carcinogenic Effectsmentioning

confidence: 61%

Section: Carcinogenic Effectsmentioning

confidence: 99%

Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Iavicoli

Leso

Bergamaschi

2012

Journal of Nanomaterials

215

207

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“…Moreover, both the Morris water maze test and the passive avoidance test revealed that exposure to TiO 2 NPs considerably distorted the inhibition and learning ability in the offspring. Jeon [92], to enhance the understanding of the molecular mechanism at protein level, carried out a proteomic analysis of protein in the brain of mice. In 11 out of 990 analysed proteins, the level of expression changed more than twice after exposure to TiO 2 NPs: eight proteins had higher and three lower expression after exposure to TiO 2 NPs.…”

Section: Nervous System the Brainmentioning

confidence: 99%

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

Baranowska‐Wójcik

Szwajgier

Oleszczuk

et al. 2019

Biol Trace Elem Res

383

222

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Recently, an increased interest in nanotechnology applications can be observed in various fields (medicine, materials science, pharmacy, environmental protection, agriculture etc.). Due to an increasing scope of applications, the exposure of humans to nanoparticles (NPs) is inevitable. A number of studies revealed that after inhalation or oral exposure, NPs accumulate in, among other places, the lungs, alimentary tract, liver, heart, spleen, kidneys and cardiac muscle. In addition, they disturb glucose and lipid homeostasis in mice and rats. In a wide group of nanoparticles currently used on an industrial scale, titanium dioxide nanoparticles—TiO2 NPs—are particularly popular. Due to their white colour, TiO2 NPs are commonly used as a food additive (E 171). The possible risk to health after consuming food containing nanoparticles has been poorly explored but it is supposed that the toxicity of nanoparticles depends on their size, morphology, rate of migration and amount consumed. Scientific databases inform that TiO2 NPs can induce inflammation due to oxidative stress. They can also have a genotoxic effect leading to, among others, apoptosis or chromosomal instability. This paper gives a review of previous studies concerning the effects of exposure to TiO2 NPs on a living organism (human, animal). This information is necessary in order to demonstrate potential toxicity of inorganic nanoparticles on human health.

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“…stress X X X [ 160 ] TiO 2 < 25 Mouse Ip 100 µg/animal; 7 days Brain: ox. stress X [ 161 ] TiO 2 < 25 Mouse Ip 100 µg/animal; 7 days Kidney: ox. stress, signal transduction X X [ 162 ] TiO 2 25 Mouse Id 5 µg/animal; 24 h Lymph node: inflammation, lipid metabolism, mRNA processing, nucleosome assembly X X [ 163 ] ZnO 35 Rat Inhal 12.1 mg/m 3 ; 24 h Lung: S100A8, S100A9, inflammation X ...…”

Section: Omics Data In Nanotoxicologymentioning

confidence: 99%

Role of omics techniques in the toxicity testing of nanoparticles

Frőhlich

2017

J Nanobiotechnol

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Nanotechnology is regarded as a key technology of the twenty-first century. Despite the many advantages of nanotechnology it is also known that engineered nanoparticles (NPs) may cause adverse health effects in humans. Reports on toxic effects of NPs relay mainly on conventional (phenotypic) testing but studies of changes in epigenome, transcriptome, proteome, and metabolome induced by NPs have also been performed. NPs most relevant for human exposure in consumer, health and food products are metal, metal oxide and carbon-based NPs. They were also studied quite frequently with omics technologies and an overview of the study results can serve to answer the question if screening for established targets of nanotoxicity (e.g. cell death, proliferation, oxidative stress, and inflammation) is sufficient or if omics techniques are needed to reveal new targets. Regulated pathways identified by omics techniques were confirmed by phenotypic assays performed in the same study and comparison of particle types and cells by the same group indicated a more cell/organ-specific than particle specific regulation pattern. Between different studies moderate overlap of the regulated pathways was observed and cell-specific regulation is less obvious. The lack of standardization in particle exposure, in omics technologies, difficulties to translate mechanistic data to phenotypes and comparison with human in vivo data currently limit the use of these technologies in the prediction of toxic effects by NPs.

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Toxicoproteomic identification of TiO₂nanoparticle-induced protein expression changes in mouse brain

Cited by 24 publications

References 34 publications

Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

Role of omics techniques in the toxicity testing of nanoparticles

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Toxicoproteomic identification of TiO2nanoparticle-induced protein expression changes in mouse brain

Cited by 24 publications

References 34 publications

Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

Role of omics techniques in the toxicity testing of nanoparticles

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Product

Resources

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Toxicoproteomic identification of TiO₂nanoparticle-induced protein expression changes in mouse brain