Toxicosis Associated with Dual Oral Exposure of Rats to Lead and Trichloroethylene

Abstract

To determine if additive or synergistic toxic effects would occur, adult male rats were exposed orally to lead carbonat e (2,000 mg/kg) for 9 days before trichloroethylen e (TCE), 2,000 mg/kg, was given concurrentl y for an additional 7 days. Comparisons were made with groups of vehicle-treated rats and rats given only lead or only TCE. Potential neurotoxicity was evaluated by using the Functional Observationa l Battery (FOB) recommended for neurotoxicity screening. Rats were sacri ced on day 16, and brain, testes, spleen, kidney/adrenals, heart, and liver weighed and observed for pathological changes. Results of the FOB indicated that lead carbonate was more responsible than TCE for changes observed. Additive or synergistic neurotoxicities were not noted. Histological examination of the kidney from lead-treated rats revealed inclusions, an increased incidence of coagulated proteins, and tubular dilation that was generally more severe in the medullary segments. Gastric and testicular necrosis were found in rats given lead carbonate both with and without TCE (15/20 and 6/20 treated, respectively). The results suggest that, even when given concurrently, the toxicities of lead carbonate and TCE are expressed only as though one toxicant was given.

Efficacy of jamun Syzygium cumini seed and orange Citrus sinensis peel extracts against microcystin LR induced histological damage in the kidney of rat

“…This is in agreement with the similar reports by Hooser et al (1989), Suput (2011) and Xiping et al, (2019), after MCLR treatment. The present study regarding dilatation of kidney tubules derives support from observations on rats (lead - Nunes et al, 2001;cadmium -Kukner et al, 2007, Tripathi andSrivastav, 2011;fenthion -Kerem et al, 2007;fenitrothion -Afshar et al, 2008;endosulfan -Khan and Kumari, 2012;chlorpyrifos -Tripathi and Srivastav, 2010), wood mouse (landfill leachates containing toxic metals - Sanchez-Chardi et al, 2009), rabbit (fluoride - Shashi et al, 2002), quails (lead -Al-Mansour et al, 2009 and fish (chlorpyrifos - Srivastava et al, 1990). Degeneration and vacuolization in the tubular cells have been noticed in MCLR treated rats.…”