Toxocara vitulorum in a suckling calf: a case study

Ahmed, Rayies; Wani, Z. A.; Allaie, I. M.; Bushra, M.; Hussain, H. A.

doi:10.1007/s12639-015-0682-0

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…This parasite that lives in the intestine of cattle and buffalo calves, its spread is currently global, and often comes from tropical and subtropical areas, is one of the most important parasites of newborn calves. 42 In one study, using the methanolic extract of Balanites aegyptiaca fruit at a concentration of 240 mg/mL showed 100% inhibitory activity on Toxocara vitulorum egg growth. 43…”

Section: Herbs' Anthelmintic Effect For Toxocara Vitulorummentioning

confidence: 99%

A review of the effect of medicinal plant on helminthic infections

Khamesipour

Kheyri

Shojaat

et al. 2021

Infect Dis Herbal Med

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Nowadays, parasitic worm infection is one of the most critical global health problems. Worm infections cause severe detriments to the livestock industry and also it can cause irreparable damages to immunocompromised persons. Therefore, the present study aimed to review conducted research on the treatment of worm diseases using medicinal plants’ extract. In this systematic review, seven databases including 4 English (Scopus, PubMed, ScienceDirect, Google Scholar) and 3 Persian databases (Magiran, ISC, SID) were obtained between 2008 and 2020 to evaluate conducted studies related to the aim of the current review. Most of the studies focused on the Balanites aegyptiaca and Carica papaya plant. Water was the most common solvent (38.1%) and then it was methanol. The most studied parasite was Haemonchus contortus (35.5%), followed by Aacharidia galli (10.5%). Studies showed that plant extracts could reduce effect of worm infections in the host compared to synthetic drugs. Plant extracts can produce a medicine based on natural compounds and effective on worms with fewer side effects than synthetic drugs.

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Section: Herbs' Anthelmintic Effect For Toxocara Vitulorummentioning

confidence: 99%

A review of the effect of medicinal plant on helminthic infections

Khamesipour

Kheyri

Shojaat

et al. 2021

Infect Dis Herbal Med

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show abstract

“…There is the GPT enzyme in various tissues, which is more concentrated in the liver. Liver injury and other pathological conditions lead to the release of this enzyme to blood, thereby increasing its level [29]. The GOT enzyme is found in the heart, liver, skeletal muscles, and in smaller amounts in other tissues.…”

Section: Biochemical Parametersmentioning

confidence: 99%

Detection of Toxocara canis infection by ELIZA, with follow-up some Biochemical and histological changes

Al-Ammash¹,

Lazar²,

Obayes³

et al. 2021

J Adv Pharm Educ Res

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“…Toxocariosis is a serious zoonotic parasitic disease with high prevalence in the tropical and subtropical regions of the world causing high morbidity and mortality rates [1]. Toxocara vitulorum is a common ascarid nematode affecting young cattle [2] and buffaloes [3,4]. This parasite can also infect other mammals and rodents as paratenic hosts [5].…”

Section: Introductionmentioning

confidence: 99%

Bone marrow mesenchymal stem cell co-adjuvant therapy with albendazole for managing Toxocara vitulorum-rat model

et al. 2021

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Background and Aim: Toxocara vitulorum is a bovine intestinal nematode. Immune pictures following infection are conflicting and stopping anthelmintic albendazole treatment recording reversed liver abnormalities. The purpose of this work was to evaluate the therapeutic potential of bone marrow mesenchymal stem cells (BMMSCs) therapy, subsequent to albendazole administration in rats infected with T. vitulorum. Materials and Methods: The ultrasonographic and histopathological examinations as well as serum liver enzymes activity and the kinetics of recovery were investigated. The correlation of cell-mediated and humoral immune pictures was assessed by assaying immunoglobulins, splenocytes viability, phagocytic index, and Th1/Th2 cytokines. Results: The cultured BMMSCs counting were 4.21×104 cells/cm2 with 96.03% viability. Flow-cytometric analysis indicated positive CD90 (82%), CD105 (79%) and negative CD34 (0.37%), CD45 (0.42%), attesting to the suitability of the isolated BMMSCs for use in therapy. Transplantation of BMMSCs after albendazole administration significantly reduced the release of liver enzymes (p<0.05) indicating liver cellularity improvement. The ultrasonographic, macroscopic, and histopathological findings confirmed the biochemical results. Significant elevation in the levels of tumor necrosis factor (TNF)-α and interferon (INF)-γ with a decline in interleukin (IL)-4 was observed in the untreated model (p<0.05). However, albendazole treatment followed by BMMSCs therapy significantly lowered the release of TNF-α and INF-γ, associated with significant production of IL-4 and IL-10 (p<0.05). Conclusion: The final results indicated that the liver functions, histopathological findings, and immune parameters were aggravated after experimental T. vitulorum infection. Albendazole treatment followed by BMMSCs therapy was found to assist in regeneration of injured hepatic tissue. Besides, it appeared to modulate host defensive immune responses against T. vitulorum antigens. This work could define more clearly the events that manipulate the host immune, histopathological, and biochemical responses to minimize obstacles in using stem cell therapy in animal toxocariosis.

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Toxocara vitulorum in a suckling calf: a case study

Cited by 9 publications

References 7 publications

A review of the effect of medicinal plant on helminthic infections

A review of the effect of medicinal plant on helminthic infections

Detection of Toxocara canis infection by ELIZA, with follow-up some Biochemical and histological changes

Bone marrow mesenchymal stem cell co-adjuvant therapy with albendazole for managing Toxocara vitulorum-rat model

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