Toxoplasmosis and the Heart

Zhou, Zier; Lopez, Hector Isaac Alejandro Ortiz; Pérez, Gonzalo; Burgos, Lucrecia María; Farina, Juan; Saldarriaga, Clara; Santi, Ricardo López; Cotella, Juan I; Pérez, Ana Laura Sauce; Baranchuk, Adrián

doi:10.1016/j.cpcardiol.2020.100741

Cited by 36 publications

(45 citation statements)

References 43 publications

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“…The prognosis in untreated immunocompetent patients is unclear. However, infection in untreated immunocompromised individuals carries high morbidity and mortality [4] . Given the availability of curative treatment, it is important to highlight and discuss the utility of detection and management of this rare finding.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is rare in immunocompetent hosts. Around one-third of the global population is infected by Toxoplasma , though it may be underdiagnosed in the United States, especially in the southern states where it is more common [4] . Contributory to this is that Toxoplasma gondii infections are often asymptomatic, with a minority of patients manifesting symptoms such as fever, headache, myalgias, lymphadenopathy, and transaminase elevation [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%

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Toxoplasma myocarditis: An atypical case in an immunocompetent patient

Mustafa

Hillyard

Nowak

et al. 2021

IDCases

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Myocarditis occurs with a variety of infectious agents including viruses, bacteria, protozoa and parasites. We present a rare case of myocarditis secondary to Toxoplasma gondii in a 23-year-old immunocompetent male presenting with acute chest pain. Workup revealed evidence of biventricular myocarditis on cardiac magnetic resonance imaging, elevated Toxoplasma serologies with rising titers over time. The patient was treated with sulfadiazine and pyrimethamine for eighteen days with resolution of symptoms. This case highlights alternative diagnostic and treatment modalities for Toxoplasma myocarditis in immunocompetent hosts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxoplasma myocarditis: An atypical case in an immunocompetent patient

Mustafa

Hillyard

Nowak

et al. 2021

IDCases

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“…Its purpose is to expand knowledge on cardiovascular (CV) involvement of these serious diseases and to help identifying barriers for diagnosis and treatment. [2][3][4] Leishmaniasis includes a heterogeneous group of clinical syndromes caused by different parasites of the genus Leishmania. 5 Most transmissions occur by phlebotomine sandfly bite and the usual reservoir hosts include humans and domestic or wild animals.…”

Section: Introductionmentioning

confidence: 99%

“…Its purpose is to expand knowledge on cardiovascular (CV) involvement of these serious diseases and to help identifying barriers for diagnosis and treatment. 2 - 4 …”

Section: Introductionmentioning

confidence: 99%

Leishmaniasis y corazón

Farina¹,

García-Martínez²,

Saldarriaga³

et al. 2021

ACM

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As one of the neglected tropical diseases, leishmaniasis is defined as a parasitic communicable disease that is most prevalent in tropical and subtropical regions, affecting especially populations living in poverty. It has a profound negative impact on developing economies. It represents a group of heterogeneous syndromes with a wide spectrum of severity ranging from self-resolving cutaneous injuries to disseminated visceral compromise. Visceral leishmaniasis represents its most severe form, can affect almost all organs, and can have fatal consequences, especially in immunosuppressed patients. Cardiac involvement seems to be rare but has not been deeply studied. Consequently, there are no clear recommendations for the screening of cardiac manifestations in these patients. However, cardiovascular complications could be potentially lethal. In addition, there are valuable reports on the potential cardiotoxicity caused by drugs used in the treatment of this condition, so knowledge of its side effects could have important implications. This article is a part of the "Neglected Tropical Diseases and other Infectious Diseases affecting the Heart" project (the NET-Heart Project); its purpose is to review all the information available regarding cardiac implications of this disease and its treatment and to add knowledge to this field of study, focusing on the barriers for diagnosis and treatment, and how to adopt strategies to overcome them.

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“…Esta revisão sistemática é parte do projeto "NET-Heart" (Neglected Tropical Diseases and Other Infectious Diseases Affecting the Heart, ou Doenças tropicais Negligenciadas e Outras Doenças Infecciosas que Afetam o Coração), uma iniciativa da seção "Líderes Emergentes" da Sociedade Interamericana de Cardiologia (SIAC). [8][9][10] O objetivo deste estudo foi expandir o conhecimento do impacto da DTN sobre a saúde cardiovascular. O objetivo desta revisão foi apresentar uma visão geral do envolvimento cardiovascular na esquistossomose e propor um algoritmo para o diagnóstico.…”

Section: Introductionunclassified

Esquistossomose e o Coração - Em Nome das Doenças Tropicais Negligenciadas e Outras Doenças Infecciosas que Afetam o Coração (Projeto NET-Heart)

Posada-Martínez¹,

Gonzalez-Barrera²,

Liblik³

et al. 2021

Arquivos Brasileiros De Cardiologia

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Fundamento: A esquistossomose é uma doença tropical negligenciada que pode levar a complicações cardiovasculares. No entanto, o envolvimento cardiovascular na esquistossomose ainda precisa ser totalmente elucidado, devido ao número limitado de casos e ausência de evidência confiável, uma vez que a doença ocorre tipicamente em locais sem infraestrutura adequada para uma coleta de dados robusta.Objetivo: Esta revisão sistemática teve como objetivo avaliar as implicações cardiovasculares da esquistossomose, incluindo no diagnóstico e tratamento, e propor um algoritmo para rastrear as manifestações cardiovasculares. Métodos: Foi realizada uma revisão sistemática nos bancos de dados MEDLINE/PubMed e LILACS, com busca por artigos sobre o comprometimento cardiovascular na esquistossomose. Resultados: Trinta e três artigos foram considerados para esta revisão: seis artigos de revisão, uma revisão sistemática, um ensaio clínico, 14 estudos observacionais, sete relatos de casos, e quatro séries de casos. O comprometimento cardiovascular inclui um amplo espectro de condições clínicas, tais como isquemia do miocárdio, disfunção ventricular, miocardite, hipertensão arterial pulmonar, e pericardite. Conclusões: As complicações cardíacas da esquistossomose podem causar incapacidade em longo prazo e morte. O monitoramento clínico, exame físico, eletrocardiograma precoce, e ecocardiograma devem ser considerados como medidas chave para detectar o envolvimento cardiovascular. Dada a ausência de um tratamento eficaz das complicações, são necessários saneamento e educação nas áreas endêmicas para a eliminação desse problema de saúde mundial.

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Toxoplasmosis and the Heart

Cited by 36 publications

References 43 publications

Toxoplasma myocarditis: An atypical case in an immunocompetent patient

Toxoplasma myocarditis: An atypical case in an immunocompetent patient

Leishmaniasis y corazón

Esquistossomose e o Coração - Em Nome das Doenças Tropicais Negligenciadas e Outras Doenças Infecciosas que Afetam o Coração (Projeto NET-Heart)

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