Introduction: The health organizations have become increasingly complex, making necessary to have various disciplines/professions engaging in an integral view of the health problems. The team work approach appears more effective and adaptive for these professional that requires recognizing their interdependency. Objective: To analyze the social interchanges and its relation with leadership, climate and satisfaction of members in Interprofessional teams in a hospital context. Methodology: Explanatory sequential mixed method (QUANT-QUAL). First phase with two stages, (1) observational, transversal and correlational including linear regression for satisfaction with the team (TS), transformational leadership (TL) and team climate (TC) and (2) social networks analysis to identify the structure and interactions among teams members. The sample size of 409 professionals of 53 teams at a university hospital in Santiago, Chile. In the qualitative phase using a descriptive design, 15 professionals from teams with results extremes and average of TS, were interviewed. The first phase used descriptive statistics, correlation, linear regression, also cohesion and centrality measurements of the formal and informal social network. Qualitative phase used thematic content analyzes. Finalizing with all the results integrated. Results: Significant associations were verified between TS, TL and TC. Linear regression with TS as the dependent variable and adjusted for age, number of members and time with the team showed that the TC (B 0,256) can largely explain TS when compared to TL (B 0,168). The nurse was recognized for the team members as the informal TL by 72% (66%-77%) and the doctor by 15% (10%-19%). Analysis of the formal networks showed that the nurse is the main source of direction to solve patient problems, the informal networks showed that the professional tend to group with others of the same profession. The analysis of teams networks with extreme results in the TS variable showed differences between those with higher and lower satisfaction in: cohesion (100%-25%), centrality (100%-57%) and intermediation (100%-36%) respectively. The interview analysis resulted in six themes: team work with shared objectives for patient centered care; collaboration in a horizontal manner in the relations; support and recognition among the members and clarity on the roles and responsibilities; good interpersonal relations and greater focus on the patient; innovation for the team work; team leadership and informal and shared leadership. The integration of the results uncover: TS requires members participation and communication, common objective strengthen towards the commitment of patient centered care, defined roles support the collaborative work and the informal TL strengthen the wellbeing, dialogue and innovation. Conclusions: The study showed that a mixed method allows an explicative and comprehensive understanding of TS. Interprofessional Teams presented significant association of TS with TC and TL, also that TC explain in greater extent ...