Trabecular bone score: a useful clinical tool for the evaluation of skeletal health in women of short stature

Alvarenga, Pedro Paulo Martins; Silva, Barbara C.; Diniz, Mariana Picoli; Leite, Milena Bellei; Silva, Caroline Alves Moreira da; Eleutério, Jessica de Cássia Mendes; Soares, Maria Marta Sarquis; Bilezikian, John P.; Camargos, Bruno Muzzi

doi:10.1007/s12020-019-02002-y

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Trabecular bone score is reportedly associated with volumetric BMD, but not area BMD, and is not influenced by bone size. [39][40][41] In the previous TBS studies involving White women in early menopause (<60 years old), the mean TBS was 1.343-1.374, and our value fell within this range. 42,43 Our value also fell within the range of mean TBS reported in studies involving White menopausal women of age (1.240-1.341).…”

Section: Trabecular Bone Score Of Postmenopausal Womensupporting

confidence: 69%

“…The influence of small bone size on BMD may result in overestimation of fracture risk. Trabecular bone score is reportedly associated with volumetric BMD, but not area BMD, and is not influenced by bone size 39–41 . In the previous TBS studies involving White women in early menopause (<60 years old), the mean TBS was 1.343‐1.374, and our value fell within this range 42,43 .…”

Section: Discussionsupporting

confidence: 51%

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Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

et al. 2022

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Section: Trabecular Bone Score Of Postmenopausal Womensupporting

confidence: 69%

Section: Discussionsupporting

confidence: 51%

Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

et al. 2022

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“…[ 5 14 ] Similar to our study, a study from Brazil evaluated the utility of BMAD and trabecular bone score in short postmenopausal women (<144 cm) and concluded that both were greater in SS when compared to their taller counterparts. [ 15 ] There were several differences between two studies. The mean age was different (69 years vs. 64 years in our study), and BMD was same in the case and control group in that study (whereas in our study, it was different) and BMAD was substantially different (0.16 g/cm 3 vs. 0.27 g/cm 3 in our study).…”

Section: Discussionmentioning

confidence: 99%

Does bone mineral apparent density facilitate accurate identification of osteoporosis in the short postmenopausal women?

Shunmugavelu

Babu

2020

Indian J Endocr Metab

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Objective: Height is one of the most important aspects affecting the areal bone mineral density (BMD). There are several height adjustments in children but none in widespread use for adults. This is specifically a problem in ethnic groups where mean height is substantially lower. We hypothesized that height adjustment of areal BMD would reduce the misclassification in short individuals. Materials and Methods: This is a retrospective study involving 373 postmenopausal women. Their records were reviewed and bone mineral apparent density (BMAD) were calculated. Areal BMD T-scores and BMAD T-scores were then compared. Results: The mean height of the cohort was 154.4 cm. There were 47 women who were defined as short (≤147 cm). In short women, BMAD neither showed improvement nor decrement in T-scores, and BMAD T-scores predicted more number of osteoporosis than BMD T-scores. When divided into height ranges, taller women (>160 cm) showed worsening of BMAD T-scores as compared to BMD T-scores (Chi-square test for trend P < 0.001). Hence, BMAD might actually “correct” for larger bone and not shorter bones. Conclusion: BMAD was not found to be a suitable alternative in short postmenopausal women to accurately determine whether the low bone density in them is because of dual-energy X-ray absorptiometry artifact or whether they truly have a low density.

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“…In differentiated thyroid carcinomas, TBS was found to be lower in patients receiving long-term suppressive doses of thyroid-stimulating hormone than in patients receiving shorter-term therapy ( 92 – 94 ). Some other studies also evaluated TBS in thalassemia major ( 95 , 96 ), Human Immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) ( 97 , 98 ), Klinefelter syndrome ( 99 ), Ehlers-Danlos syndrome ( 100 ), Down syndrome ( 101 ), and short stature ( 102 ).…”

Section: Tbs and Fracture Risk Prediction In Patients With Diabetes A...mentioning

confidence: 99%

Update on trabecular bone score

Palomo¹,

Muszkat²,

Weiler³

et al. 2022

Archives of Endocrinology and Metabolism

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Trabecular bone score (TBS) is an indirect and noninvasive measure of bone quality. A low TBS indicates degraded bone microarchitecture, predicts osteoporotic fracture, and is partially independent of clinical risk factors and bone mineral density (BMD). There is substantial evidence supporting the use of TBS to assess vertebral, hip, and major osteoporotic fracture risk in postmenopausal women, as well as to assess hip and major osteoporotic fracture risk in men aged > 50 years. TBS complements BMD information and can be used to adjust the FRAX (Fracture Risk Assessment) score to improve risk stratification. While TBS should not be used to monitor antiresorptive therapy, it may be potentially useful for monitoring anabolic therapy. There is also a growing body of evidence indicating that TBS is particularly useful as an adjunct to BMD for fracture risk assessment in conditions associated with increased fracture risk, such as type-2 diabetes, chronic corticosteroid excess, and other conditions wherein BMD readings are often misleading. The interference of abdominal soft tissue thickness (STT) on TBS should also be considered when interpreting these findings because image noise can impact TBS evaluation. A new TBS software version based on an algorithm that accounts for STT rather than BMI seems to correct this technical limitation and is under development. In this paper, we review the current state of TBS, its technical aspects, and its evolving role in the assessment and management of several clinical conditions.

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Trabecular bone score: a useful clinical tool for the evaluation of skeletal health in women of short stature

Cited by 9 publications

References 30 publications

Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

Does bone mineral apparent density facilitate accurate identification of osteoporosis in the short postmenopausal women?

Update on trabecular bone score

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