Trace analysis of phenolic compounds in water by in situ acetylation coupled with purge and trap-GC/MS

Zhong, Sheng; Su, Guanyong; Liu, Hongling; Dai, Xingui; Wang, Rongjun; Cai, Huanxing; H, Yu

doi:10.1039/c2ay05887a

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…However, although it is possible to detect phenols directly by using mass spectrometry, it is not specific to phenol detection. Consequently, a common approach used for the specific detection of phenols involves the use of reagents to selectivity derivatize the phenols prior to detection to make them more amenable for analysis by chromatography, or for direct detection by mass spectrometry …”

Section: Introductionmentioning

confidence: 99%

Mass spectrometric detection of the Gibbs reaction for phenol analysis

Mistry

Wenthold

2018

J Mass Spectrom

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This paper describes a new method for detecting phenols, by reaction with Gibbs reagent to form indophenols, followed by mass spectrometric detection. Unlike the standard Gibbs reaction, which uses a colorometric approach, the use of mass spectrometry allows for simultaneous detection of differently substituted phenols. The procedure is demonstrated to work for a large variety of phenols without para-substitution. With para-substituted phenols, Gibbs products are still often observed, but the specific product depends on the substituent. For para groups with high electronegativity, such as methoxy or halogens, the reaction proceeds by displacement of the substituent. For groups with lower electronegativity, such as amino or alkyl groups, Gibbs products are observed that retain the substituent, indicating that the reaction occurs at the ortho or meta position. In mixtures of phenols, the relative intensities of the Gibbs products are proportional to the relative concentrations, and concentrations as low as 1 μmol/L can be detected. The method is applied to the qualitative analysis of commercial liquid smoke, and it is found that hickory and mesquite flavors have significantly different phenolic composition.

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Section: Introductionmentioning

confidence: 99%

Mass spectrometric detection of the Gibbs reaction for phenol analysis

Mistry

Wenthold

2018

J Mass Spectrom

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Analytical Aspects

2021

Automated Sample Preparation

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Metabolic pathway elucidation towards time- and dose-dependent electrophoretic screening of stable oxidative phenolic compounds

2013

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This study demonstrates an untested link between model phenolic compounds and the formation/electrophoretic separation of stable urinary metabolites. Sterically encumbered carbonyl groups were examined, and mass determination was used to confirm the presence and stability of two oxidative metabolites of pentachlorophenol: tetrachloro-1,2-benzoquinone and tetrachloro-1,4-dihydroquinone. Subsequently, baseline resolved separation of pentachlorophenol and the two oxidative metabolites was demonstrated under the following conditions: 75 mM sodium tetraborate buffer (pH = 8.5) with 5 % methanol and 50 mM SDS, +10.0 kV running voltage, injection time = 5.0 s, effective capillary length = 55 cm, and run temperature = 20 °C. Results not only provide key metabolic inferences for pentachlorophenol, they also exhibit improvements in the ability to separate and detect changes in urinary metabolites in response to phenolic-related exposure.

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Trace analysis of phenolic compounds in water by in situ acetylation coupled with purge and trap-GC/MS

Cited by 8 publications

References 26 publications

Mass spectrometric detection of the Gibbs reaction for phenol analysis

Mass spectrometric detection of the Gibbs reaction for phenol analysis

Analytical Aspects

Metabolic pathway elucidation towards time- and dose-dependent electrophoretic screening of stable oxidative phenolic compounds

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