Trace determination of isopropyl methylphosphonofluoridate (GB) and bis (2-chloroethyl) sulfide (HD) in chemical neutralization solutions by gas chromatography-mass spectrometry

Stuff, John R.; Cheicante, Richard L.; Morrissey, Kevin M.; Durst, H. D.

doi:10.1002/(sici)1520-667x(2000)12:2<87::aid-mcs4>3.0.co;2-h

Cited by 5 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other workers have shown that these methods can adequately be employed for the analysis of chemical warfare agents and pesticides. GC‐MS and NMR analysis of sulfur mustard and sarin was elaborated in many studies, of which some recent examples are given (7–10). Diazinon is commonly analyzed at trace levels by GC‐MS (11,12).…”

mentioning

confidence: 99%

The Fate of the Chemical Warfare Agent During DNA Extraction*

Wilkinson

Hulst

Reuver

et al. 2007

Journal of Forensic Sciences

View full text Add to dashboard Cite

Forensic laboratories do not have the infrastructure to process or store contaminated DNA samples that have been recovered from a crime scene contaminated with chemical or biological warfare agents. Previous research has shown that DNA profiles can be recovered from blood exposed to several chemical warfare agents after the agent has been removed. The fate of four toxic agents, sulfur mustard, sodium 2-fluoroacetate, sarin, and diazinon, in a lysis buffer used in Promega DNA IQ extraction protocol was studied to determine if extraction would render the samples safe. Two independent analytical methods were used per agent, selected from GC-MS, 1H NMR, 19F NMR, (31)P NMR, or LC-ES MS. The methods were validated before use. Determinations were carried out in a semi-quantitative way, by direct comparison to standards. Agent levels in the elution buffer were found to be below the detectable limits for mustard, sarin, sodium 2-fluoroacetate or low (<0.02 mg/mL) for diazinon. Therefore, once extracted these DNA samples could be safely processed in a forensic laboratory.

show abstract

mentioning

confidence: 99%

The Fate of the Chemical Warfare Agent During DNA Extraction*

Wilkinson

Hulst

Reuver

et al. 2007

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

Utilisation of separation methods in the analysis of chemical warfare agents

et al. 2006

View full text Add to dashboard Cite

Chemical warfare agents and their degradation products represent a broad group of compounds with different chemical properties (polarity, volatility, thermostability, etc.). These chemicals often have to be detected and determined in complex matrices and therefore highly efficient separation techniques hyphenated to selective and sensitive detectors play an indispensable role. This review offers an overview of selected papers devoted to the title subject. It cannot be considered as a comprehensive literature compilation but should allow the reader to obtain an insight into the application of separation techniques in the important area of human protection and control of chemical weapons.

show abstract