Trace element status of hemodialyzed patients

Krachler, Michael; Wirnsberger, Gerhard; Irgolic, Kurt J.

doi:10.1007/bf02917472

Cited by 46 publications

(54 citation statements)

References 13 publications

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“…In an earlier study (Krachler et al, 1997a), we could establish 10-fold increased plasma Co concentrations in 68 hemodialysed patients (2.05 mgaL, range 1.14 to 3.25 mgaL) caused by clinical treatment. Probably, adults and infants do not have adequate mechanisms of homeostasis developed to prevent elevated serum Co levels.…”

Section: Discussionmentioning

confidence: 93%

“…Therefore, whole blood, plasma, and serum are generally convenient samples for the determination of the trace element status of a person. A number of investigations have been carried out over the years to assess reference values for trace elements in these body liquids (Caroli et al, 1994;Krachler et al, 1997aand b, Ru Èkgauer et al, 1997. Almost all studies concentrated on the trace element status of adult subjects.…”

Section: Introductionmentioning

confidence: 99%

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Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

1999

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Objective: To investigate the trace element transfer from the mother to the newborn. Design: The concentrations of the eight essential elements calcium (Ca), cobalt (Co), copper (Cu), magnesium (Mg), manganese (Mn), molybdenum (Mo), tin (Sn), and zinc (Zn), and of the non-essential and toxic elements barium (Ba), beryllium (Be), bismuth (Bi), cadmium (Cd), cesium (Cs), lanthanum (La), lithium (Li), lead (Pb), rubidium (Rb), antimony (Sb), strontium (Sr), and thallium (Tl) were determined in umbilical cord (n 29) and corresponding maternal sera (n 29) as well as in colostrum (n 27). Results: Umbilical cord serum concentrations of Ca, Mn, and Zn were 120%, 150%, and 148% of the maternal value, respectively. Maternal sera had twice the Cu concentrations found in healthy adults and ®ve-times higher Cu than umbilical cord sera. Concentration ratios colostrumamaternal serum and colostrumaumbilical cord serum were approximately one for Co, 1.4 for Mg, two for Ca, Mn, and Sn, ®ve for Cu (maternal serum), eight for Mo, and ten for Zn. Concentrations of the toxic elements Cd and Pb decreased in the order colostrum (Pb 2.6 mgaL; Cd 0.6 mgaL), maternal sera (0.8 mgaL; 0.3 mgaL), umbilical cord sera (0.4 mgaL; 0.2 mgaL). Maternal serum Ba and Rb was 182% and 66% of the umbilical cord value. For Sr and Li, an almost perfect correlation between umbilical cord and maternal sera was found. For Ba, Co, Cu, Mn, Zn none, and for Ca, Cs, Mn, Mo, Rb only weak positive correlations between these two compartments could be established. Conclusions:The results of this study indicate that an active transport mechanism for the transport of Ca, Mn, Rb, and Zn from the mother to the newborn exists, whereas Cs, Li, and Sr follow concentration gradients. As regards Cu, the placenta showed to have a blocking effect on the transfer from the mother to the baby.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

1999

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“…Michael Krachler et al, who determined toxic and trace elements in the plasma samples of 68 haemodialysis patients by inductively coupled plasma mass spectrometry, had demonstrated a higher concentration of cadmium than the high limits for healthy adults [32]. D Van Renterghem et al, had demonstrated elevated concentrations of cadmium in the sera of five patients who were on haemodiafiltration [31].…”

Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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Background: In India, there is a rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop chronic kidney disease (CKD), with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. Derangements in the metabolism of several toxic and trace elements such as antimony, arsenic cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal functions. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead, or vanadium are high in end-stage renal disease (ESRD). Aim and Objectives:Our aim was to study the levels of blood arsenic and cadmium in ESRD patients who were on maintenance haemodialysis (MHD), and to study whether there was any relationship between their concentrations and the duration of the MHD. Methods:The blood lead levels were determined in 50 healthy subjects with normal renal functions and in 50 patients with ESRD, who were on MHD. None of them had any history of smoking or any industrial exposure. Results:The results of the study revealed that the blood arsenic and cadmium concentrations were higher in the ESRD patients who were on MHD than in the healthy adults. The blood arsenic and cadmium concentrations were found to increase with the duration of the MHD. Conclusion:The mild increase in the blood arsenic and cadmium concentrations, with an increase in the duration of the MHD in the study population, may be viewed in the wider context, that a prolonged exposure to arsenic and cadmium, even at low levels, may result in renal damage and/or progression of an already existing CKD.

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“…Michael Krachler et al, had demonstrated a higher concentration of lead than the high limits for healthy adults [6]. Martegani et al, described a significant increase in the erythrocyte [7] protoporphyrin IX levels in patients with chronic renal failure and in those who were on haemodialysis.…”

Section: Discussionmentioning

confidence: 99%

Blood Lead in End-Stage Renal Disease (ESRD) Patients who were on Maintainence Haemodialysis

Rajan²,

Silambanan³

et al. 2012

JCDR

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Background: In India, there is rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop CKD, with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. The derangements in the metabolism of several toxic and trace elements such as antimony, arsenic, cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal function. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead and vanadium are high in ESRD. Aim and Objectives:Our aim was to study the levels of blood lead in the End-Stage Renal Disease (ESRD) patients who were on Maintenance Haemodialysis (MHD), and to study whether there was any relationship between the blood lead concentration and the duration of MHD. Methods:The blood lead level was determined in 50 healthy subjects with normal renal function and in 50 patients with ESRD who were on MHD. None of them had a history of smoking or any industrial exposure. Results:The results of this study revealed that the blood lead level was higher in the ESRD patients who were on MHD than in the healthy adults. The blood lead concentration was found to increase with the duration of the MHD.

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Trace element status of hemodialyzed patients

Cited by 46 publications

References 13 publications

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Blood Lead in End-Stage Renal Disease (ESRD) Patients who were on Maintainence Haemodialysis

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