Trace elements differences in the depression sensitive and resilient rat models

Xu, Long; Zhang, Shihong; Chen, Wei; Yan, Lailai; Chen, Yan; Hua, Wen; Liu, Duojian; Rosenblat, Joshua D.; Wang, Jingyu; Cao, Bing

doi:10.1016/j.bbrc.2020.05.228

Cited by 18 publications

(10 citation statements)

References 36 publications

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“…Selenium concentrations were also significantly lower in patients with major depressive disorder compared to controls in Bangladesh ( p < 0.05) ( 12 ). In rats, higher levels of selenium have been shown to be protective against the development of depressive symptoms in response to stress ( 13 ). Despite this, the evidence is still contradictory ( 9 – 11 , 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Selenium Intake and Development of Depression in Brazilian Farmers

et al. 2021

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Introduction: Depression and deficiency in the consumption of micronutrients are a public health problem, especially in the rural population. The deficiency in selenium consumption affects mental health, contributing to the development of major depressive disorders. Thus, this study aimed to evaluate selenium intake and its association with depressive symptoms in farmers in southeastern Brazil.Material and Methods: Epidemiological, cross-sectional, and analytical study with 736 farmers aged between 18 and 59. A semistructured questionnaire was used to collect sociodemographic, lifestyle and clinical condition data. For evaluation of food intake, three 24-h recalls were applied, and for identification of depressive episodes, the Mini-International Neuropsychiatric Interview was conducted.Results: A total of 16.1% (n = 119) of the farmers presented symptoms of major depressive episodes, 5.8% (n = 43) presented symptoms of current depressive episodes, and 10.3% (n = 76) presented symptoms of recurrent major depressive episodes. Sociodemographic factors associated with depression were gender (p < 0.001), marital status (p = 0.004), and socioeconomic class (p = 0.015). The consumption of high doses of selenium was associated with a reduction of ~54% in the chances of occurrence of depression (OR = 0.461; 95% CI = 0.236–0.901).Conclusion: High selenium intake is associated with a lower prevalence of depression even after adjusting for sociodemographic variables, lifestyle, and pesticide intoxication. The findings of this study contributed to highlighting the high prevalence of depression in rural areas and its relationship with selenium intake.

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Section: Introductionmentioning

confidence: 99%

Association of Selenium Intake and Development of Depression in Brazilian Farmers

et al. 2021

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“…Therefore, If there is a dysregulation between the CRH and HPA systems, this would further affect stress hormones, such as cortisol, which will affect depressive symptoms (72). Second, extracellular Ca influx is an important component of many neuronal processes (73). The change of extracellular Ca 2+ concentration may participate in emotion regulation, which may be the direct effect of Ca on stabilizing the plasma membrane, and methyl-D-aspartate may also affect neural plasticity (74).…”

Section: Discussionmentioning

confidence: 99%

Association between dietary calcium and depression among American adults: National health and nutrition examination survey

Shen

Liu

et al. 2023

Front. Nutr.

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BackgroundThere is only limited evidence for an association between calcium (Ca) and depression, and the relationship was inconsistent. Therefore, the aim of this study was to assess the relationship between dietary Ca and the risk of depressive symptoms in individuals over the age of 18 in the US.MethodsWe extracted 14,971 participants from the US National Health and Nutrition Examination Survey (NHANES) 2007–2016 to probe their associations. Dietary Ca intake was measured through 24 h dietary recall method. Patients with the Patient Health Questionnaire-9 (PHQ-9) ≥ 10 scores were believed to have depressive symptoms. The association between dietary Ca and depressive symptoms was investigated using multivariate logistic regression, sensitivity analysis, and restricted cubic spline regression.ResultsIn this study, 7.6% (1,144/14,971) of them had depressive symptoms. After adjusting for sex, age, race, poverty to income ratio (PIR), marital status, education, body mass index (BMI), caffeine intake, carbohydrates intake, total energy intake, smoking status, alcohol consumption, physical activity, diabetes, hypertension, severe cardiovascular disease (CVD), cancer, serum vitamin D, serum Ca, and Ca supplement, the adjusted ORs value [95% confidence interval (CI)] of depression for the lowest category (Q1 ≤ 534 mg/day) vs. Q2–Q4 of Ca intake were 0.83 (0.69–0.99), 0.97 (0.65–0.95), and 0.80 (0.63–0.98) with the p for trend (p = 0.014). The relationship between dietary Ca intake and depressive symptoms was linear (non-linear p = 0.148). None of the interactions were significant except among races (p for interaction = 0.001).ConclusionAssociation between dietary Ca and the prevalence of depressive symptoms in US adults. And Ca intake was negatively associated with the risk of depressive symptoms. As Ca intake increased, the prevalence of depressive symptoms decreased.

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“…On the other hand, there are more robust data encouraging the use of zinc supplementation in patients with MDD, as it seems to augment the efficacy of antidepressants [ 223 ] even in non-responsive patients [ 224 ]. Notwithstanding there is still little and inconsistent evidence regarding selenium and manganese supplementation, further studies are needed in this field, as they also control some central processes and functions in the brain [ 225 , 226 ]. In case of iron, it is well-known its central role in brain organization.…”

Section: Nutraceuticals In Mddmentioning

confidence: 99%

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

et al. 2021

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Major depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in most severe cases. However, an important percentage of depressed patients fail to respond to the use of conventional therapies. This has created the urgency of finding novel approaches to help in the clinical management of those individuals. Nutraceuticals are natural compounds contained in food with proven benefits either in health promotion or disease prevention and therapy. A growing interest and economical sources are being placed in the development and understanding of multiple nutraceutical products. Here, we summarize some of the most relevant nutraceutical agents evaluated in preclinical and clinical models of depression. In addition, we will also explore less frequent but interest nutraceutical products which are starting to be tested, also evaluating future roads to cover in order to maximize the benefits of nutraceuticals in MDD.

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Trace elements differences in the depression sensitive and resilient rat models

Cited by 18 publications

References 36 publications

Association of Selenium Intake and Development of Depression in Brazilian Farmers

Association of Selenium Intake and Development of Depression in Brazilian Farmers

Association between dietary calcium and depression among American adults: National health and nutrition examination survey

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

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