Trace elements in human physiology and pathology. Copper

Tapiero, Haïm; Townsend, Danyelle M.; Tew, Kenneth D.

doi:10.1016/s0753-3322(03)00012-x

Cited by 872 publications

(576 citation statements)

References 201 publications

(219 reference statements)

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“…Dietary Cu is absorbed mainly in the duodenum and is chelated by metallothioneins in the cytoplasm of cells 5 . Cu binds to proteins involved in a variety of biological processes 6 such as the formation, maturation and stabilization of connective tissues and structure of the extracellular matrix 7 . Cu is involved in the detoxification of reactive oxygen species as it binds to metallothioneins under reducing conditions and influences the activity of antioxidant enzymes 6 .…”

Section: Introductionmentioning

confidence: 99%

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

et al. 2016

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. Design of the study, acquisition of data, critical revising and final approval of the version to be published. ABSTRACT PURPOSE:This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS:The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. RESULTS: CONCLUSION:These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.

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Section: Introductionmentioning

confidence: 99%

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

et al. 2016

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“…53 Low plasma selenium levels have been associated with accelerated progression of HIV disease among adults, 68 pregnant women in Tanzania, 69 children and children born to HIV infected mothers in Tanzania. 70,71 Significance of serum metallothionein and ceruloplasmin levels in HIV infection Ceruloplasmin has a principal function of transporting and delivery of copper to the tissue, 72 which is increased during inflammation or stress. Copper concentrations, unlike iron and zinc, increase as part of the acute-phase response.…”

Section: Impact Of Trace Elements Deficiencies In Hiv Infectionmentioning

confidence: 99%

Untitled

2018

TJNPR

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“…Cu is necessary for structural and catalytic activity of a variety of important enzymes, including cytochrome C oxidase, tyrosinase, dopamine beta hydroxylase (DBH) and Cu-zinc super oxidase dismutase (Cu, Zn SOD). Cu supplements were used to treat anemia among animals since 1920s and Cu deficiency was documented among humans in the 1960s, respectively (1). Sources of environmental exposure to Cu include water pipes, cookware, contraceptive pills, vitamin and minerals supplements and fungicides with Cu is added for swimming pools.…”

Section: Introductionmentioning

confidence: 99%

Hematological and hepatic alterations among copper mine workers and office employees in a copper mine in the west of Iran, 2015

Lotfi

Rezazadeh

Ebrahimpour

2018

JOHE

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Article InfoBackground: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mine workers (study group) and 52 office employees (control group) during winter 2015. 5ml blood samples were provided from each subject and hematological and hepatic parameters including white blood cell (WBC), platelet (PLT), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCH), lymphocytes, neutrophils, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum Cu levels have been determined using their commercial kits. The results were analyzed in the SPSS software using t-test and regression method. Results: ALT, AST, HGB, MCV, MCH and plasma Cu levels among the workers were significantly higher than the office employees (p<0.050). WBC and RBC counts among the workers were significantly lower than the control group (p= 0.049 and 0.024, respectively). Serum Cu levels of 215 of the workers were higher than its normal recommended range (120 µg/dl). For the subjects with serum Cu levels above 150 µg/dl, increases in AST and ALT were in compliance with serum Cu levels increase. Conclusions: Significant hepatic and hematological alteration were observed among copper miners compared to control group. Employment of workers with background hematological and hepatic disorders in copper industries must be accompanied with great caution.

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Trace elements in human physiology and pathology. Copper

Cited by 872 publications

References 201 publications

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

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Hematological and hepatic alterations among copper mine workers and office employees in a copper mine in the west of Iran, 2015

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