Trace Elements in Sickle Cell Disease

Prasad, Ananda S.; Ortega, Jesús; Brewer, George J.; Oberleas, Donald; Schoomaker, Eric B.

doi:10.1001/jama.1976.03260480016021

Cited by 78 publications

(26 citation statements)

References 8 publications

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“…The above explanation may thus explain the finding of a significant positive correlation between serum copper levels and MCH (r = 0.418; P = 0.02, Table 1 and Figure 2) in this study. We did not observe any significant correlation between serum copper and mean cell volume (MCV) and neutrophil counts (r = -0.266; P = 0.17 and r = 0.132; P = 0.50, respectively, Table 1), this is in contrast to the report of Prasad et al [8]. The reason for this discrepancy could not be explained from this study.…”

Section: Discussioncontrasting

confidence: 99%

“…Even though the clinical relevance of this elevation is not completely understood, a number of studies have associated this with decreased serum zinc levels [7,21]. Prasad et al reiterated this finding and noted that these patients in addition, have microcytosis and relative neutropaenia [8]. These abnormalities were reversed following copper supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…These appeared to have a consensus that SCA subjects have lower serum levels of micro nutrients when compared with normal (hemoglobin AA) controls [7][8][9][10]. It has similarly been observed that changes in serum levels of a number of micro nutrients tend to induce secondary changes in blood counts in non SCA subjects [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Chide

John

Patrick

et al. 2015

Zahedan J Res Med Sci

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Chide

John

Patrick

et al. 2015

Zahedan J Res Med Sci

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“…123 Growth retardation and hypogonadism were observed in zinc-depleted men, suggesting its contribution to impaired growth and sexual maturation in SCD. 81,124 In 104 American children (0.4-18 yrs), low plasma zinc was reported in 44% of SS cases and, compared with SS cases with normal plasma zinc, was associated with impairment of height, weight, FFM, skeletal growth and sexual and skeletal maturation. 125 Supplements of elemental zinc (10 mg/day) given for 12 months to 20 children with SCD led to improved rates of linear growth but there was no effect on BMI.…”

Section: Micronutrient Deficiencymentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

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“…Zinc plays critical roles in en zyme structure and function, in cell differentiation and growth, and in stress and injury responses (4,7,9,10,(16)(17)(18)(19). The stability of the serum zinc concentra tion under normal conditions and the apparent centrality of its function in a wide range of biologic processes would suggest the presence of one or more physiologic control mechanisms for the maintenance of cellular and/or serum zinc concentration (17,21).…”

Section: Introductionmentioning

confidence: 99%

Influence of Cholecalciferol on Tissue Zinc Homeostasis in the Rat

Chausmer¹,

Ward²,

Zears³

1980

Ann Nutr Metab

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A role for calciferol in zinc homeostasis was investigated by radioisotope uptake and compartmental analysis techniques. Cholecalciferol was injected into rats 4–5 days prior to radioisotopic study of rapidly exchangeable pools ( < 4 h). Kidney, liver, and duodenum had significant increases in zinc uptake rates. Bone and skeletal muscle had significant decreases. No other tissues had significant differences. Compartmental analysis models generated by the SAAM-25 digital computer program suggested a decrease in the fractional tissue to plasma coefficient to be the mechanism for the observed changes in the serum zinc concentration and tissue zinc accumulation rates. It is not clear whether this is a specific effect of calciferol on zinc homeostasis or is a nonspecific response which may reflect some role for zinc in calciferol metabolism.

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Trace Elements in Sickle Cell Disease

Cited by 78 publications

References 8 publications

Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Growth and nutritional status of children with homozygous sickle cell disease

Influence of Cholecalciferol on Tissue Zinc Homeostasis in the Rat

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