Trace metal composition of synovial fluid and blood serum of patients with rheumatoid arthritis

Niedermeier, William; Griggs, James H.

doi:10.1016/0021-9681(71)90128-7

Cited by 93 publications

(28 citation statements)

References 17 publications

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“…No increase in transferrin concentration was found in RA SF. The concentration is, however, high enough to bind about 4 times the amount of iron known to be present in SF (19). In most systems transferrin-bound iron is not able to catalyze the formation of OH'.…”

Section: Discussionmentioning

confidence: 99%

Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid

Biemond

Swaak

Koster

1984

Arthritis & Rheumatism

121

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Oxygen free radicals are probably involved in the pathogenesis of rheumatoid arthritis (RA). The enzymes involved in protection against oxygen free radicals and H2O2 (superoxide dismutase, catalase, and glutathione peroxidase) were measured. Superoxide dismutase was not increased, glutathione peroxidase was slightly and catalase was strongly elevated in RA synovial fluid (SF) compared with control SF. Although these enzymes are present in SF, the activities are insufficient to protect against oxygen free radicals and H2O2. In contrast to transferrin, ferritin was increased in RA synovial fluid. Ceruloplasmin was also elevated. When rat liver microsomes were used as a target for oxygen free radicals, serum and SF were both protective. Gel filtration experiments showed that the fraction pattern in which there was maximal protective potential against lipid peroxidation corresponded closely to the level of ceruloplasmin. After removal of ceruloplasmin from serum or SF, about 70% of the protective capacity disappeared. It is concluded that ceruloplasmin is an important protector against oxygen free radicals.

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Section: Discussionmentioning

confidence: 99%

Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid

Biemond

Swaak

Koster

1984

Arthritis & Rheumatism

121

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“…Synovial fluid from rheumatoid arthritis patients has been observed to contain more Al than normal while the serum content decreased (368)(369)(370)(371). However, in infectious nonspecific polyarthritis the serum level increased 2-fold.…”

Section: August 1974mentioning

confidence: 99%

Aluminum in the Environment and Human Health

Sorenson¹,

Campbell²,

Tepper³

et al. 1974

Environmental Health Perspectives

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The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses are presented. It is concluded that absorption and retention or accumulation of Al in humans occurs at lower levels of intake than had been assumed formerly. However, levels of 5 to 50 times the normal daily intake do not appear to interfere with other metabolic processes. The adverse effects of Al reported in the more recent years resulted from the inhalation or ingestion of Al in concentrations many times greater than the amounts present under normal circumstances. As in the past, there is still no need for .ncern by the public or producers of Al or its products concerning hazards to human health derived from well established and extensively used products.

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“…Nevertheless this can not be taken as a general rule. For example serum (or plasma) zinc was found to be decreased in rat with turpentine abscesses [11], endotoxemia and Francisiella tulariensis infection [12], adjuvant arthritis [13], and in man experimentally infected with sandly fever virus [14] or affected by active rheumatoid arthritis [15,16]. Conversely the injection of complete Freund's adjuvant in the dog [17] caused an increase in serum zinc concentrations, and similar data were reported studying mixed connective tissue disease in man [16].…”

Section: Introductionmentioning

confidence: 99%

Copper and zinc status during acute inflammation: studies on blood, liver and kidneys metal levels in normal and inflamed rats

et al. 1986

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The concentrations of copper and zinc in plasma, blood cells, liver and kidneys were determined in a study performed on normal female rats, and in female rats with carrageenan induced pleurisy. In the normal rat, the total amount of both metals increases, from 51 to 79 days of age, in all the compartments examined. This increase was mostly, and in some case exclusively, dependent upon the growth of the animal, although high individual and day to day variations in both copper and zinc values were observed in all the compartments studied. In the blood of inflamed rats a statistically significant increase in copper was measured during the crucial hours of the experiment (i.e. from 6 to 72 h); over 90% of the increase found was attributable to variations in plasma copper concentration values. In the liver of inflamed rats a statistically significant increase in zinc was measured at 6, 22 and 48 h after the carrageenan injection. The induction of the acute non-infective inflammatory process did not cause quantitative changes of both copper and zinc in all the other compartments considered in the present study. These results seem to suggest that, during acute inflammation, the organism increases its requirement for copper and zinc, and that this demand is fulfilled by enhanced intestinal absorption and/or decreased intestinal excretion of both metals.

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Trace metal composition of synovial fluid and blood serum of patients with rheumatoid arthritis

Cited by 93 publications

References 17 publications

Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid

Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid

Aluminum in the Environment and Human Health

Copper and zinc status during acute inflammation: studies on blood, liver and kidneys metal levels in normal and inflamed rats

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