Trace Metals in a Family with Sex-Linked Retinitis Pigmentosa

Bastek, James V.; Bogden, John D.; A, Cinotti; tenHove, Willem; Stephens, George; Markopoulos, M; Charles, James

doi:10.1007/978-1-4899-5010-9_6

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…Zinc ions are able to influence the transformation of retinol into retinal by means of zinc-dependent metabolic processes (Smith, 1982). Various investigations evaluating zinc and copper metabolism in retinitis pigmentosa (Bastek et al, 1977;Marmor, 1985) and other types of retinal disorders (Figueroa et al, 1971;Silverstone et al, 1985) have been performed.…”

Section: Introductionmentioning

confidence: 99%

On the recovery of the electroretinogram after removal of intravitreal zinc particles

1987

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The influence of intravitreal zinc particles (1.3 mm2) in the eyes of rats caused the amplitudes of the electroretinogram to decrease to about 50% of the initial values within 24 hours, whereas the prolongation of the peak times began only on the third day after particle implantation. The removal of the zinc particles after 30 days led to only partial recovery of the amplitudes, whereas the peak times reached normal values. Dissociated behaviour of the amplitudes and peak times as described here was not found in earlier experiments with intravitreal iron, copper or lead particles of the same size. The extraction of intravitreal zinc particles (1.3 mm2) one day after implantation resulted in a recovery of the amplitudes up to 85%.

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Section: Introductionmentioning

confidence: 99%

On the recovery of the electroretinogram after removal of intravitreal zinc particles

1987

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“…There are minor differences between the values in the different hereditary types, but there is no evidence that patient values are unusually high or low in any hereditary form of the disease. A recent report (Bastek et al, 1977) suggested that Xlinked patients may have serum copper levels in excess of carriers. In our 1 X-linked family grouping the patient's copper level of 115 ,ug/100 ml [imol/l) was between the values for 2 carriers in his family, namely, 108 and 120 [±g/lOO ml (17-0 and 18-8 [Lmol/1).…”

Section: Serum Copper Valuesmentioning

confidence: 99%