Tracers for metabolic imaging of brain and heart

Stöcklin, G.

doi:10.1007/bf00185860

Cited by 50 publications

(9 citation statements)

References 137 publications

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“…To this end radioisotopes are commonly used tools, yielding quantitative measures of the organ distribution of a drug (Antar, 1990;Kung, 1990; Stocklin, 1992). Noninvasive imaging permits the time sequence monitoring of the distribution of a drug (Antar, 1990;Kung, 1990;Reba, 1993;Stocklin, 1992). However, radio nuclear images may suffer from limited spatial resolution, making it difficult to apply to laboratory animal models such as mice.…”

Section: Introductionmentioning

confidence: 99%

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

Halpern¹,

Perić²,

Yu³

et al. 1996

Biophysical Journal

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A novel, very-low-frequency electron paramagnetic resonance (EPR) technique is used to image the distribution of several nitroxides with distinct pharmacologic compartment affinities in the abdomens of living mice. Image acquisition is sufficiently rapid to allow a time sequence of the distribution for each compound. The spectra and concentrations of these nitroxides are imaged with the use of spectral-spatial imaging to distinguish a single spatial dimension. Liver and bladder of the mouse anatomy are distinguished by this technique. After an intraperitoneal injection of the spin-label probes, a shift in the distribution of the compounds from the upper abdomen (primarily liver) to the lower abdomen (primarily bladder) is observed. The time dependence of the shift in regional distribution depends on the structural properties of the side chain attached to the spin label. These results indicate that this application of in vivo electron paramagnetic resonance imaging will provide a new method of magnetic resonance imaging for determination of pharmacodynamics in the body of an intact animal.

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Section: Introductionmentioning

confidence: 99%

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

Halpern¹,

Perić²,

Yu³

et al. 1996

Biophysical Journal

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“…It has been difficult to apply PET and SPET techniques to the study of 5-HT receptor systems in schizophrenia, due to the lack of selective 5-HT radioligands (Stocklin, 1992). PET studies have attempted to assess S-HT2A binding in schizophrenic subjects using the non-selective D2/5-HT2A receptor ligand 11C-N-methyl-spiperone (11C-NMSP) (Farde et al, 1994(Farde et al, , 1995.…”

Section: -Htg Receptormentioning

confidence: 99%

Perspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia

Busatto¹,

Kerwin²

1997

J Psychopharmacol

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In recent years, a number of research findings has renewed interest in the possible role of serotonin (5-HT) in the pharmacology of schizophrenia. Atypical antipsychotics that potently block 5-HT receptors have been shown to be at least as effective as classical antipsychotics as well as producing fewer extrapyramidal side-effects. In addition, molecular biological studies have suggested that allelic variations of 5-HT receptor genes may affect both susceptibility to schizophrenia and clinical response to atypical antipsychotics. Building on these findings, this article proposes that 5-HT receptors are critical sites of antipsychotic action, and examines the implications of this to the treatment and pathophysiology of schizophrenia. Possible pharmacological mechanisms underlying the clinical efficacy of 5-HT blocking antipsychotics are discussed, and the potential of functional neuroimaging techniques to further elucidate these mechanisms is emphasized.

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“…Besides FDG, there have been many advances in developing new class of radiotracers to diagnose cancer and to interrogate certain neurological processes. O-15 water (blood flow), 2 F-18 labeled fatty acids (fatty acid/thiokinase metabolism), 3 F-18 FLT (thymidine kinase), 4 F-18 fluoroestradiol (estrogen receptor targeting),…”

Section: Positron Emission Tomography/computerized Tomography (Pet/ct)mentioning

confidence: 99%

Role of Molecular Imaging in Oncology

Garg¹,

Batra²,

Garg³

et al. 2014

Cancer Stud Mol Med Open J

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Tracers for metabolic imaging of brain and heart

Abstract: Major tracers for probing regional metabolism and neuroreceptor binding in brain and heart with positron emission tomography (PET) and single photon emission tomography (SPET) are critically reviewed with special emphasis on radiochemical, kinetic and radiopharmacological aspects.

Cited by 50 publications

References 137 publications

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

Perspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia

Role of Molecular Imaging in Oncology

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