Traces of intact paraben molecules in endometrial carcinoma

It has been widely demonstrated that endocrine disruptors play a central role in various physiopathological processes of human health. In the literature, various carcinogenic processes have been associated with endocrine disruptors. A review of the molecular mechanisms underlying the interaction between endocrine disruptors and the endometrial cancer has been poorly developed. A systematic review was performed using PubMed®/MEDLINE. A total of 25 in vivo and in vitro works were selected. Numerous endocrine disruptors were analyzed. The most relevant results showed how Bisphenol A (BPA) interacts with the carcinogenesis process on several levels. It has been demonstrated how BPA can interact with hormonal receptors and with different transcription proliferative and antiproliferative factors. Furthermore, the effect of Polycyclic aromatic hydrocarbons on Aryl hydrocarbon receptors was investigated, and the role of flame retardants in promoting proliferation and metastasis was confirmed. The results obtained demonstrate how the mechanisms of action of endocrine disruptors are manifold in the pathophysiology of endometrial cancer, acting on different levels of the cancerogenesis process.

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“…Paraben molecules N-Propylparaben and isobutyl + N-butylparaben were the most frequently detected [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Endocrine Disruptors and Endometrial Cancer: Molecular Mechanisms of Action and Clinical Implications, a Systematic Review

Caserta

Marco

Besharat

et al. 2022

IJMS

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“…As mentioned above, detectable levels of PBs and BPs have been detected in endometrial tissue and menstrual blood [29,71]. Trace levels of intact PBs were predominantly detected in endometrial carcinoma tissues (23%) in contrast to normal endometrium samples (2%), and thus, authors suggested that they might be related to an increased risk of endometrial carcinoma [71].…”

Section: Associations Between Pcp-and Cosmetic-released Edcs and Endometriosismentioning

confidence: 94%

“…Some studies have also addressed the potential association between exposure to PCP-released EDCs and the origin and development of other female diseases. In this regard, the presence of trace levels of PBs was found in endometrial tissue samples suspected of being related to an increased risk of endometrial carcinoma [71]. Levels of PrP were also related to diminished ovarian reserve in a prospective cohort study of the US women seeking fertility treatment [72].…”

Section: Use Of Cosmetics and Pcps And Feminine Diseasesmentioning

confidence: 95%

Endocrine Disrupting Chemicals in Cosmetics and Personal Care Products and Risk of Endometriosis

Peinado¹,

Iribarne-Durán²,

Ocón‐Hernández³

et al. 2021

Endometriosis

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In the last years, the variety and consumption of cosmetics and personal care products (PCPs) have greatly increased, although the long-term adverse effects to low doses of chemicals used in their production and with proven hormone-mimicking properties have been still poorly addressed. Among these endocrine disrupting chemicals (EDCs), parabens, benzophenones, bisphenols, and phthalates are the most widely found in these products. Given the estrogenic-dependent nature of the endometrium, it has been hypothesized the potential contribution of these EDCs contained in cosmetics and PCPs in the risk of endometriosis. In this book chapter, we have summarized the current evidence supporting this hypothesis, highlighting epidemiological, in vivo, and in vitro studies that have addressed the potential influence of parabens, benzophenones, bisphenols, and phthalates in the origin and progression of this chronic feminine disease.

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“…1 Over 90% of ovarian cancers are derived from epithelial cells and are frequently diagnosed at a late stage, with low overall survival rates. 1,2 A growing body of research suggests multiple gynaecological cancers are associated with exposure to pollutants, including organochlorine compounds, 3 heavy metals, 4,5 parabens, 6 organic chlorines, 7,8 and endocrine-disrupting chemicals. 9,10 Ovarian cancer risk has been associated with diesel and gasoline engine exhaust fumes, 11 and with specific industrial toxic emissions.…”

Section: Introductionmentioning

confidence: 99%

Ambient particulate matter air pollution exposure and ovarian cancer incidence in the USA: An ecological study

Kentros,

Huang,

Wylie

et al. 2023

BJOG

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ObjectiveTo investigate associations between air particulate matter of ≤2.5 μm in diameter (PM2.5) and ovarian cancer.DesignCounty‐level ecological study.SettingSurveillance, epidemiology, and end results from a collection of state‐level cancer registries across 744 counties. Data from the Environmental Protection Agency's network for PM2.5 monitoring was used to calculate trailing 5‐ and 10‐year PM2.5 county‐level values. County‐level data on demographic characteristics were obtained from the American Community Survey.PopulationA total of 98 751 patients with histologically confirmed ovarian cancer as a primary malignancy from 2000 to 2016.MethodsGeneralised linear regression models were developed to estimate the association between PM2.5 and PM10 levels, over 5‐ and 10‐year periods of exposure, and ovarian cancer risk, after accounting for county‐level covariates.Main outcome measuresRisk ratios for associations between ovarian cancer (both overall and specifically epithelial ovarian cancer) and PM2.5 levels.ResultsFor the 744 counties included, the average PM2.5 level from 1990 through 2018 was 11.75 μg/m3 (SD = 3.7) and the average PM10 level was 22.7 μg/m3 (SD = 5.7). After adjusting for county‐level covariates, the overall annualised ovarian cancer incidence was significantly associated with increases in 5‐year PM2.5 (RR = 1.11 per 10 units (μg/m3) increase, 95% CI 1.06–1.16). Similarly, when the analysis was limited to epithelial cell tumours and adjusted for county‐level covariates there was a significant association with trailing 5‐year PM2.5 exposure models (RR = 1.12 per 10 units increase, 95% CI 1.08–1.17). Likewise, 10‐year PM2.5 exposure was associated with ovarian cancer overall and with epithelial ovarian cancer.ConclusionsHigher county‐level ambient PM2.5 levels are associated with 5‐ and 10‐year incidences of ovarian cancer, as measurable in an ecological study.

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Traces of intact paraben molecules in endometrial carcinoma

Cited by 15 publications

References 39 publications

Endocrine Disruptors and Endometrial Cancer: Molecular Mechanisms of Action and Clinical Implications, a Systematic Review

Endocrine Disruptors and Endometrial Cancer: Molecular Mechanisms of Action and Clinical Implications, a Systematic Review

Endocrine Disrupting Chemicals in Cosmetics and Personal Care Products and Risk of Endometriosis

Ambient particulate matter air pollution exposure and ovarian cancer incidence in the USA: An ecological study

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