Tracheal and bronchoalveolar permeability changes in rats inhaling oxidant atmospheres during rest or exercise

Abstract

Permeability of tracheal and bronchoalveolar airways of rats was measured and used to examine the effects of inhaled oxidant-containing atmospheres. The atmospheres studied were (a) ozone (O

Immunological reactivity under conditions of prolonged exposure to ozone

“…Such a decrease in this parameter is characteristic of large industrial centers with high technogenic pollution [2,3,7]. In workers with more than 2 years of service, IgA concentrations were within the same range, but lower in comparison with both control groups, particularly in subjects often suffering from acute respiratory viral infections with a history of chronic bronchitis; this is in line previously reported direct correlation between high morbidity and IgA deficit [3,8,9,11].…”

Effects of pollutant atmospheres on surface receptors of pulmonary macrophages

“…Exposure for 21 d to twice the concentrations of the 7-component atmosphere increased permeability in rats examined on d 7 and 21 of exposure, but the increase was not present in rats that recovered from exposure for 1 or more days (Bhalla et al, 1987). This finding suggested that permeability was increased even when histologic lesions in the lung were absent.…”

Toxic Effects of Short-Term Exposures to Acids and Diesel Exhaust

“…Abraham et al (1982) exposed sheep to 1.6 ppm (5.5 mg/m3) nitric acid for 4 hours and found that airway reactivity to aerosolized carbachol was increased. Studies with an ozone + nitrogen dioxide atmosphere at high relative humidity, in which nitric acid was readily formed, showed that both airway permeability and lung pathology were altered (Bhalla et al, 1987;Mautz et al, 1988). In these studies effects were seen when the ozone and nitrogen dioxide concentrations were as low as 0.35 ppm and 0.6 ppm, respectively, and the associated nitric acid formed was about 0.05 mg/m3.…”