Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

Abstract

BackgroundTracheal cancers (TC) are rare and treatment results that are reported are typically not satisfactory. The purpose of this research was assessment of the results of treatment of TC patients, identification of potential additional surgery candidates, evaluation of prognostic factors, and assessment of the occurrence of other malignancies.Patients and methodsThe Regional Cancer Database and the Hospital Database were searched for patients with tracheal neoplasms. Fifty-eight of 418 patients identified initially, met the inclusion criteria (primary TC with confirmed histology and complete treatment records). Standard statistical tests were used.ResultsSquamous cell carcinoma (SCC; 63.8%) and adenoid cystic carcinoma (ACC; 15.5%) were the most commonly diagnosed histological types of TC. Radiotherapy was delivered in 48 cases, surgery or endoscopic resection in 20, and chemotherapy in 14. TC was diagnosed as a second cancer in 10 patients, in 1 patient it occurred prior to the lung cancer, and in 1 was diagnosed simultaneously. During the median follow-up of 12.7 months, 85.5% of the patients died because of the disease. Local recurrence occurred in 17% cases. In univariate analysis, patients with ACC had statistically better five-year overall survival (77.8%) than those diagnosed with SCC (8.4%, p = 0.0001). Radiotherapy, performance status and haemoptysis were factors significantly influencing overall survival (OS) in the multivariate analysis. Among patients who were not treated surgically, 15–26% were found to constitute additional surgery candidates, depending on the selection criteria.ConclusionsThe diagnostic workup should be focused on the identification of TC patients suitable for invasive treatment and radiotherapy. Respiratory system cancer survivors can be considered a risk group for tracheal cancer. Radiotherapy constitutes an important part of the treatment of patients with TC.

A case of adenoid cystic carcinoma of trachea: treatment complications and radiotherapy role

“…Amongst 8 patients receiving brachytherapy, hemorrhage was reported only once. The rest of patients did not develop any clinical signs of toxicity after this treatment [ 17 ].…”

<p>Competing risk analysis of primary tracheal carcinoma based on SEER database</p>

“…The inadequacy was that the survival time could not be predicted and could not be compared with previous literature. On the other hand, with the wide application of comprehensive treatment of tumor, postoperative adjuvant radiotherapy had been proved to improve survival,13 while SEER database did not have detailed records of other treatment measures such as radiotherapy, resulting in the incomplete selection of potential prognostic factors, leading to decreased reliability of the conclusion.…”

3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report

“…For those inoperable patients, radiotherapy remains to be the first-line treatment (9). Though some other forms of treatment such as new types of radiotherapy and endoscopic resection (10,11) have been invented and practiced, their long-term outcomes compared with that of traditional resection remains unclear because of its low morbidity. Currently, Doggett S et al have reported that 3 patients with tracheal ACC were implanted with 103 Pd under CT-fluoroscopic guidance utilizing percutaneous approach and responded well in the short-term with no chronic side effects (12).…”