Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits

Bone marrow mesenchymal stem cells could acquire the phenotypes of epithelial cells and accelerate vaginal reconstruction combined with small intestinal submucosa

“…The graft of SIS combined with autologous oral mucosal epithelial cells promotes reepithelialization and muscular regeneration in a cervical esophageal defects model of male beagle dogs (Wei et al, 2009). As far as tracheal reconstruction was concerned, SIS combined MSCs showed minimal tracheal stenosis, minimal infiltration of the inflammatory cells, and granulation tissue formation, and regeneration of pseudostratified columnar epithelium compared to the untreated group and SIS group in rabbits (Du et al, 2012a).…”

Retrospective evaluation of corneal reconstruction usingACell Vet™alone in dogs and cats: 82 cases

“…Porcine small intestinal submucosa (SIS) and porcine urinary bladder matrix (UBM) have been used extensively to repair defects of the esophagus, bladder, cervicovagina, rectum, urethra, ureter, trachea, blood vessels, orbital floor, thoracic wall, and tendon and ligaments in humans and various animal species. SIS has been investigated extensively and has been used successfully in dogs, cats, and horses to repair various corneal or scleral defects .…”

Tracheal reconstruction with asymmetrically porous polycaprolactone/pluronic F127 membranes

“…However, trachea replacements using prosthetic or biological substitutes have thus far yielded unsatisfactory results, preventing their clinical application . The failures of these methods have been mainly because of donor site restrictions, immunologic complications, bacterial infections, an excessive time required for tissue culture, the need for a second stage operation, material failure, and tracheal lumen obstruction . In general, prosthetic reconstruction of the trachea is much more difficult than is the case for blood vessels.…”