Tracheal replacement: A never–ending search

Rendina, Erino Angelo; Randhawa, Simran

doi:10.1111/ajt.17179

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…The goal of tracheal reconstruction is to provide a non-collapsible airway with a stable epithelial lining and reliable, well-vascularized tissue coverage (Yu et al, 2006;Delaere et al, 2010;Yu et al, 2011;Rendina and Patterson, 2022;Yang et al, 2023). To achieve this goal, in the present study, we applied a partially decellularized tracheal scaffold to provide airway support and successfully covered its lumen with RECs to provide a functional respiratory lining.…”

Section: Discussionmentioning

confidence: 99%

Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Zeng

Han

et al. 2023

Front. Bioeng. Biotechnol.

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Graphical AbstractScheme of the experimental design. 1, CTA derived from donor Brown Norway rats was de-epithelialized to create DeCTA. 2, RECs were isolated from syngeneic recipient Lewis rats. 3, DeCTA was pre-epithelialized to create ReCTA. 4, In the heterotopic implantation model, ReCTA was subcutaneously implanted into the groin area, and an adipose tissue flap pedicled by superficial epigastric blood vessels was used for neovascularization. 5, In the orthotopic implantation model, DeCTA was implanted into the neck to reconstruct a 4-ring tracheal defect.

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Section: Discussionmentioning

confidence: 99%

Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Zeng

Han

et al. 2023

Front. Bioeng. Biotechnol.

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“…When confronted with such scenarios, patients find themselves navigating treatment modalities like tracheal reconstruction, slide tracheoplasty, and innovative artificial substitutes. Nevertheless, the efficacy of these solutions is compromised by complications such as granulation formation and gradual implant weakening over time, posing critical challenges to their sustained performance 4,5 . Consequently, an imperative has emerged for the investigation of the strategies for facilitating the development of tracheal‐like structures.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the efficacy of these solutions is compromised by complications such as granulation formation and gradual implant weakening over time, posing critical challenges to their sustained performance. 4 , 5 Consequently, an imperative has emerged for the investigation of the strategies for facilitating the development of tracheal‐like structures.…”

Section: Introductionmentioning

confidence: 99%

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Wei,

Zhang,

Luo

et al. 2024

Bioengineering & Transla Med

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Restoration of extensive tracheal damage remains a significant challenge in respiratory medicine, particularly in instances stemming from conditions like infection, congenital anomalies, or stenosis. The trachea, an essential element of the lower respiratory tract, constitutes a fibrocartilaginous tube spanning approximately 10–12 cm in length. It is characterized by 18 ± 2 tracheal cartilages distributed anterolaterally with the dynamic trachealis muscle located posteriorly. While tracheotomy is a common approach for patients with short‐length defects, situations requiring replacement arise when the extent of lesion exceeds 1/2 of the length in adults (or 1/3 in children). Tissue engineering (TE) holds promise in developing biocompatible airway grafts for addressing challenges in tracheal regeneration. Despite the potential, the extensive clinical application of tissue‐engineered tracheal substitutes encounters obstacles, including insufficient revascularization, inadequate re‐epithelialization, suboptimal mechanical properties, and insufficient durability. These limitations have led to limited success in implementing tissue‐engineered tracheal implants in clinical settings. This review provides a comprehensive exploration of historical attempts and lessons learned in the field of tracheal TE, contextualizing the clinical prerequisites and vital criteria for effective tracheal grafts. The manufacturing approaches employed in TE, along with the clinical application of both tissue‐engineered and non‐tissue‐engineered approaches for tracheal reconstruction, are discussed in detail. By offering a holistic view on TE substitutes and their implications for the clinical management of long‐segment tracheal lesions, this review aims to contribute to the understanding and advancement of strategies in this critical area of respiratory medicine.

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Bioprothèses trachéobronchiques. Remplacement trachéobronchique par allogreffe aortique cryopréservée stentée

Martinod,

Radu,

Onorati

et al. 2024

Bulletin de l'Académie Nationale de Médecine

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Tracheal replacement: A never–ending search

Cited by 4 publications

References 6 publications

Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Bioprothèses trachéobronchiques. Remplacement trachéobronchique par allogreffe aortique cryopréservée stentée

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