2015
DOI: 10.1016/j.jpedsurg.2014.07.005
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Tracheoplasty with cartilage-engineered esophagus environments

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Cited by 10 publications
(11 citation statements)
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“…[45] utilized GA in different concentrations as a crosslinker with no report of cytotoxicity. In our study, no destructive effects on chondrocytes were observed to be caused by the concentration of 0.8 wt% GA similar to the data reported by Komura and coworkers[46] based on crosslinking gelatin sponges with 0.16 wt% GA. GA concentration affects mechanical characteristics, swelling ratio, and degradation, which are significant features of an optimized scaffold. As it can be seen in the FTIR spectra (Fig.…”
Section: Discussionsupporting
confidence: 92%
“…[45] utilized GA in different concentrations as a crosslinker with no report of cytotoxicity. In our study, no destructive effects on chondrocytes were observed to be caused by the concentration of 0.8 wt% GA similar to the data reported by Komura and coworkers[46] based on crosslinking gelatin sponges with 0.16 wt% GA. GA concentration affects mechanical characteristics, swelling ratio, and degradation, which are significant features of an optimized scaffold. As it can be seen in the FTIR spectra (Fig.…”
Section: Discussionsupporting
confidence: 92%
“…In pre-clinical studies, the most common site for harvesting differentiated chondrocytes is auricular elastic cartilage [ 60 – 67 ]. Despite the hyaline nature of tracheal rings, there is some evidence that the origin of chondrocyte does not affect the success of tracheal hyaline regeneration in pre-clinical small patch tracheoplasties [ 67 – 69 ].…”
Section: Autologous Cell Choices For Tracheal Regenerationmentioning
confidence: 99%
“…Outcome measures in studies involving chondrocyte seeding have included the persistence of chondrocytes within scaffolds for up to 14 weeks post-operatively [ 60 , 69 , 76 80 ] and the detection of appropriate extracellular matrix protein deposition, specifically collagen, elastin, and GAGs [ 62 , 81 ]. Areas of “neocartilage” formation following chondrocyte seeding have been reported in several small pre-clinical studies of synthetic [ 60 , 68 , 78 , 81 ] and decellularized [ 70 ] grafts, though few of these reports include unseeded control groups, making data interpretation somewhat difficult. Moreover, these reports have not included comments on the functionality of the new cartilage in contributing to the mechanical stability of grafts, despite the particular relevance of this in studies where scaffolds are manufactured from biodegradable material.…”
Section: Autologous Cell Choices For Tracheal Regenerationmentioning
confidence: 99%
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“…Thus, the use of personalized 3DP for TM remains to be defined. Potential therapies recently studied in animal models might include tissue-engineering techniques with collagenous connective tissue membranes (bio sheets) as a potential tracheal substitute material (21,22). These will have to be validated in humans prior to implementation in practice.…”
mentioning
confidence: 99%