2013
DOI: 10.1016/j.heares.2013.05.003
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Tracing Sox10-expressing cells elucidates the dynamic development of the mouse inner ear

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Cited by 36 publications
(36 citation statements)
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“…However, our data on melanocyte migration toward their target location in the cochlea, which to our knowledge has not been shown before in such clarity, suggests that cochlear melanocytes in humans migrate through the periotic mesenchyme from the opposite side. In agreement, several studies in mice embryos show the presence of neural crest derivatives or melanocytes near this part of the otic vesicle around embryonic day 10.5 (Steel et al, 1992; Freyer et al, 2011; Adameyko et al, 2012; Wakaoka et al, 2013; Sandell et al, 2014). Therefore, although the peripheral glial cells in the cochlea originate from the migratory wave of neural crest cells from rhombomere 4, we now hypothesize that cochlear melanocytes originate from a different wave of neural crest cells, namely those delaminating from the region at rhombomere 6, at the location of the developing glossopharyngeal nerve (cranial nerve IX) and the third pharyngeal arch.…”
Section: Discussionsupporting
confidence: 68%
See 1 more Smart Citation
“…However, our data on melanocyte migration toward their target location in the cochlea, which to our knowledge has not been shown before in such clarity, suggests that cochlear melanocytes in humans migrate through the periotic mesenchyme from the opposite side. In agreement, several studies in mice embryos show the presence of neural crest derivatives or melanocytes near this part of the otic vesicle around embryonic day 10.5 (Steel et al, 1992; Freyer et al, 2011; Adameyko et al, 2012; Wakaoka et al, 2013; Sandell et al, 2014). Therefore, although the peripheral glial cells in the cochlea originate from the migratory wave of neural crest cells from rhombomere 4, we now hypothesize that cochlear melanocytes originate from a different wave of neural crest cells, namely those delaminating from the region at rhombomere 6, at the location of the developing glossopharyngeal nerve (cranial nerve IX) and the third pharyngeal arch.…”
Section: Discussionsupporting
confidence: 68%
“…The developmental pattern of melanocyte distribution observed in the human fetal cochlea closely follows that of the mouse, where it is generally accepted that cochlear melanocytes are derived from the neural crest (Steel et al, 1992; Freyer et al, 2011; Wakaoka et al, 2013). Therefore, we suggest that the melanocytes in the human cochlea are also derived from the neural crest.…”
Section: Discussionmentioning
confidence: 56%
“…Neural crest precursor cells have been shown to give rise to a wide range of cell types, including craniofacial chondrocytes, sensory and autonomic neurons, peripheral glial cells, and melanocytes including intermediate cells in the stria vascularis. Our findings have concurred with previous studies showing that the Sox10 gene is expressed in the stria vascularis, in particular in intermediate cells of postnatal mouse ears [61], [62]. The intense Sox10 immunoreactivity in strial intermediate cells of early postnatal and adult mice supports the neural crest derivation of intermediate cells as previously reported [63].…”
Section: Discussionsupporting
confidence: 93%
“…Since Sox10 labels neural crest derived cells including Schwann cells in the cochleovestibular ganglion (CVG) [28, 40, 41], we used Sox10 as a marker for glial cells in the spiral ganglion. We used TuJ1 as a marker for delaminating neuroblasts as well as delaminated neurons [29, 42]. At E10.5, when neuroblasts are in the process of delaminating from the anteroventral otic vesicle [4], TuJ1 positive delaminating neuroblasts as well as cells in the neural tube and in the otocyst expressed Sox2-EGFP and Sox2 protein (Fig 1A arrowheads, Fig 1A’ and 1A”).…”
Section: Resultsmentioning
confidence: 99%
“…Sox2 and Sox10 are first expressed in the developing proneurosensory region of the otocyst and continue to be expressed in glia throughout adulthood [8, 29]; however, changes in expression of these factors during development and maturation of PANs remains unclear. Developing PANs also express Gata3, Mafb and Prox1 until neonatal stages [6, 3035]; however, the spatial and temporal patterns of gene expression in maturing PANs for these transcription factors have not yet been resolved.…”
Section: Introductionmentioning
confidence: 99%