Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation

Moon, Rebecca J; Crozier, Sarah; Dennison, Elaine; Davies, Justin H; Robinson, Siân; Inskip, Hazel; Godfrey, Keith M.; Cooper, Cyrus; Harvey, Nicholas C.

doi:10.3945/ajcn.115.115295

Cited by 40 publications

(48 citation statements)

References 31 publications

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“…This model explained about 20% of the variation in season-corrected change in 25(OH)D during pregnancy. Moon et al showed that vitamin D supplementation is related to changes in 25(OH)D between the first and the third trimester, which supports our findings [12]. However, we did not observe the effects of gestational weight gain on 25(OH)D change seen in that study.…”

Section: Discussionsupporting

confidence: 87%

“…This pattern was also seen for the subgroup born in Africa and Asia. Why season would have greater influence on serum concentrations of 25(OH)D in late pregnancy is uncertain, but a similar pattern was also indicated by Moon et al who performed a similar season-correction of 25(OH)D concentrations [12]. …”

Section: Discussionmentioning

confidence: 58%

“…However, Zhang et al report a downward 25(OH)D trajectory during pregnancy [9]. The only previous study investigating the season-corrected analysis of gestational 25(OH)D change showed decreasing 25(OH)D concentrations [12]. This may partly be explained by less vitamin D supplement use in late pregnancy than in early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Since data on gestational vitamin D status in populations living at latitudes without seasonality in cutaneous vitamin D synthesis are scarce, a season-corrected analysis is a way of investigating changes in 25(OH)D during pregnancy per se. Such analyses of 25(OH)D concentrations during pregnancy show that vitamin D status between early and late pregnancy tracks moderately and that change depends on supplement use, gestational weight gain and physical activity [12]. …”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

et al. 2016

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There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 25-hydroxyvitamin D (25(OH)D) (N = 1985) was analysed by liquid chromatography tandem-mass spectrometry. Season-corrected 25(OH)D was calculated by fitting cosine functions to the data. Mean (standard deviation) 25(OH)D was 64.5(24.5) nmol/L at T1 and 74.6(34.4) at T3. Mean age was 31.3(4.9) years, mean body mass index (BMI) was 24.5(4.2) kg/m2 and 74% of the women were born in Sweden. Vitamin D deficiency was common among women born in Africa (51%) and Asia (46%) and prevalent in 10% of the whole cohort. Determinants of vitamin D deficiency at T1 were of non-North European origin, and had less sun exposure, lower vitamin D intake and lower age. Season-corrected 25(OH)D increased by 11(23) nmol/L from T1 to T3. The determinants of season-corrected change in 25(OH)D were origin, sun-seeking behaviour, clothing style, dietary vitamin D intake, vitamin D supplementation and recent travel <35° N. In conclusion, season-corrected 25(OH)D concentration increased during pregnancy and depended partly on lifestyle factors. The overall prevalence of vitamin D deficiency was low but common among women born in Africa and Asia. Among them, the determinants of both vitamin D deficiency and change in season-corrected vitamin D status were fewer, indicating a smaller effect of sun exposure.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

et al. 2016

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“…However, our samples were collected up to a week after birth, and it is possible that 25(OH)D concentration might have decreased slightly during this week after birth as exclusive breastfeeding is a predictor of vitamin D deficiency among infants [41]; and in Denmark, <5% of infants are not being breastfed at the time of hospital discharge [42]. However, the tracking of 25(OH)D during pregnancy was previously shown to be moderate [43] and half-life of 25(OH)D is 2-3 weeks; furthermore, vitamin D supplementation for infants is recommended after age 2 weeks; therefore not affecting neonatal 25(OH)D concentrations [44]. Hence, we can be assured that our measurements are a good indicator of the vitamin D concentration in the last month of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study

et al. 2020

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Background: low vitamin D status in pregnancy can influence the offspring's lung function and contribute to childhood asthma development. The objective of this study was to examine the influence of neonatal vitamin D status on the development of asthma among children age 3-9 years in a large population sample. Method: in a case-cohort study utilizing a Danish biobank and register data we examined the association between neonatal 25-hydroxyvitamin D 3 (25(OH)D 3 ) concentrations and incidence of asthma among children aged 3-9 years. Cases of asthma (n = 911) were randomly selected among all cases of asthma in the Danish National Patient Register from children born between 1992 and 2002. The sub-cohort (n = 1423) was randomly selected among all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first asthma diagnoses by quintiles of 25(OH)D 3 . Results: the median 25(OH)D3 (interquartile range) for asthma cases was 23 nmol/L (14-35) and the sub-cohort 25 nmol/L (14-40). The hazard ratio for developing asthma between ages 3 and 9 years was lower for children in the fifth quintile of neonatal 25(OH)D 3 compared to children in the first quintile, both in the unadjusted (0.61 95% CI: 0.46-0.80) and adjusted (0.55 95% CI: 0.39-0.77) analyses. Conclusion: the results from our study suggest that higher neonatal vitamin D concentration may reduce the risk of developing childhood asthma at ages 3-9 years, indicating that neonatal vitamin D status as a proxy of vitamin D status during the prenatal period is important for normal immune-and lung development.

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Regimens of vitamin D supplementation for women during pregnancy

Palacios

Trak-Fellermeier

Martinez³

et al. 2019

Cochrane Database of Systematic Reviews

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Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation

Cited by 40 publications

References 31 publications

Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study

Regimens of vitamin D supplementation for women during pregnancy

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