Tracking of Drug Release and Material Fate for Naturally Derived Omega-3 Fatty Acid Biomaterials

Abstract

In vitro and in vivo studies were conducted on Omega-3 fatty acid-derived biomaterials to determine their utility as an implantable material for adhesion prevention following soft tissue hernia repair and as a means to allow for the local delivery of antimicrobial or antibiofilm agents. Naturally derived biomaterials offer several advantages over synthetic materials in the field of medical device development. These advantages include enhanced biocompatibility, elimination of risks posed by the presence of toxic catalysts and chemical cross-linking agents, and derivation from renewable resources. Omega-3 fatty acids are readily available from fish and plant sources and can be used to create implantable biomaterials either as a stand-alone device or as a device coating that can be utilized in local drug delivery applications. In-depth characterization of material erosion degradation over time using non-destructive imaging and chemical characterization techniques provided mechanistic insight into material structure/function relationship. This in turn guided rational tailoring of the material based on varying fatty acid composition to control material residence time and hence drug release. These studies demonstrate the utility of Omega-3 fatty acid derived biomaterials as an absorbable material for soft tissue hernia repair and drug delivery applications.

Hybrid cell constructs consisting of bioprinted cell‐spheroids

“…70,71 For this reason, the effect of the mineral oil that was used in the formation of the spheroids on in vivo results and complex biological functions will be studied in our future work. Additionally, more biocompatible and safer hydrophobic oils [72][73][74] also could be considered for the One-SP.…”

Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective

“…The most common primary implant components to date include synthetic nonabsorbable polypropylene (PP), polyester, and polytetrafluorethylene; synthetic absorbable polylactic-co-glycolic acid; polyhydroxybutyrate or related polymers; biologic origin material such as dermal and visceral origin collagen; and sometimes additional components such as silk, hydrogel, oxidized cellulose, and omega-3 fatty acids (Trandafir, Popa, and Vasile 2017; Zhu, Schuster, and Klinge 2015; Müller-Stich et al 2014; Yang et al 2017; Faucher et al 2015). Component fibers may be monofilament or polyfilament, and some devices are composite and include more than one type of material.…”