Tracking of the degradation process of chlorhexidine digluconate and ethylenediaminetetraacetic acid in the presence of hyper-pure chlorine dioxide in endodontic disinfection

Herczegh, Anna; Palcsó, Barnabás; Zsolt, Lohinai; Zelkó, Romána

doi:10.1016/j.jpba.2018.11.005

Cited by 10 publications

(12 citation statements)

References 25 publications

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“…According to the results of the present study, a fair amount of increase was found in the OD values of the EDTA + ClO 2 and SC + ClO 2 groups; however, this increase was found to be statistically similar to the negative control group (p>0.05) ( Figure 6 ). This increase in the OD levels of the EDTA + ClO 2 group may be due to the decrease in antibacterial activity as a result of the ClO 2 -oxidizing effect against EDTA ( 26 ). In addition, this increase in the OD values of the samples treated with SC+ClO 2 was found to be lower than that of EDTA + ClO 2 ( Figure 6 ).…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Özkan

Çobankara

Sayın

et al. 2020

Acta Stomatol Croat

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Objectives This study assessed the antibacterial activity of both separate and combined uses of 5.25% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX), 17% ethylenediaminetetraacetic acid (EDTA), 3% hydrogen peroxide (H 2 O 2 ), MTAD, SmearClear (SC) and 13.8% chlorine dioxide (ClO 2 ) irrigation solutions against Enterococcus faecalis. Materials and Methods Two hundred eighty single rooted human premolars were randomly grouped into 26 test and 2 control (negative and positive) groups and were incubated for 24 h with E. faecalis , except for the negative control group. The tested solutions were as follow: NaOCl; CHX; ClO 2 ; MTAD; SC; EDTA; H 2 O 2 ; NaOCl + CHX; NaOCl + MTAD; SC + NaOCl; EDTA + NaOCl; H 2 O 2 + NaOCl; ClO 2 + CHX; CHX + MTAD; SC + CHX; EDTA + CHX; CHX + H 2 O 2 ; ClO 2 + MTAD; SC + ClO 2 ; EDTA + ClO 2 ; ClO 2 + H 2 O 2 ; SC+MTAD; EDTA+MTAD; MTAD + H 2 O 2 ; SC + H 2 O 2; and EDTA + H 2 O 2. Optic density values were recorded at 0, 6, 12, 18, 24, 30, 36, 42 and 48 h and bacterial growth curve created for each solution. Results The CHX, MTAD and ClO 2 showed a high potential for the elimination of E. faecalis, both alone and in all combinations. The EDTA, H 2 O 2 , H 2 O 2 + EDTA, H 2 O 2 + NaOCl and SC + NaOCl groups showed less antibacterial activity than the other groups. The SC + CHX group showed the best antibacterial effect against E. faecalis . Conclusion The SC + CHX combination can be recommended as the most effective irrigation regimen against E. faecalis in persistent endodontic infections.

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Section: Discussionmentioning

confidence: 98%

“…According to the results of the present study, ClO 2 + CHX is effective in the elimination of E. faecalis . These two agents do not form any reactions nor do they negatively influence each other ( 26 , 27 ) and they maintain their antibacterial activity at all times when used in combinations ( Figure 4,6 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Özkan

Çobankara

Sayın

et al. 2020

Acta Stomatol Croat

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“…[8][9][10] However, there is limited information about the reactions of ClO 2 . Anna et al 29 reported the results of an in vitro study using an high performance liquid chromatography-mass spectroscopy (HPLC/MS) method, which showed that free PCA did not appear after mixing of 1% CHX and 0.12% hyper-pure ClO 2 . That supports our findings on free PCA.…”

Section: Discussionmentioning

confidence: 99%

Proton Nuclear Magnetic Resonance Spectroscopy Analysis of Mixtures of Chlorhexidine with Different Oxidizing Agents Activated by Photon-Induced Photoacoustic Streaming for Root Canal Irrigation

Özkan

Terlemez

Orhan

2020

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: The aim of this in vitro study was to investigate the possible interactions between photon-induced photoacoustic streaming (PIPSÔ)-activated oxidizing agents and 2% chlorhexidine digluconate. Background data: There is no information about the safety of laser-activated oxidizing agents in combination usage with chlorhexidine gluconate. Materials and methods: Groups were designed as follows G1: 98% para-chloroaniline (PCA); G2: 2% chlorhexidine (CHX); G3: 5.25% sodium hypochlorite (NaOCl) +2% CHX; G4: 5.25% NaOCl (30 sec PIPS activated) +2% CHX; G5: 5.25% NaOCl (60 sec PIPS activated) +2% CHX; G6: 3.5% chlorine dioxide (ClO 2 ) + 2% CHX; G7: 3.5% (ClO 2 ) (30 sec PIPS activated) +2% CHX; G8: 3.5% (ClO 2 ) (60 sec PIPS activated) +2% CHX. The laser-irrigation protocol was performed with an erbium:yttrium-aluminum-garnet laser with a wavelength of 2940 nm equipped with a 140 mm long endodontic fiber tip (PIPS) using 10 mJ at 15 Hz (0.15 W), per pulse operating outputs. Groups were analyzed with proton nuclear magnetic resonance spectroscopy, using PCA as an internal standard. Results: No free PCA was formed in any groups of mixtures or after PIPS activation. Conclusions: Mixing of 3.5% ClO 2 and 2% CHX does not form bulky precipitates, unlike the mixture NaOCl + CHX. PIPS activation does not cause changes in reactions of oxidizing agents.

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“…Additionally, in the last decade, the direct dental application of chlorine dioxide has gained substantial interest. The compound was investigated as a root canal irrigant in vitro [33][34][35][36][37][38][39]. The whitening effect of chlorine dioxide was evaluated in vitro [40] and in vivo [41,42].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

Kerémi

Korbonits

Farkas

et al. 2020

CPD

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Background: Effective and selective oral rinses are required in the daily medical and dental practice. Currently used mouthwashes have substantial side effects. Objectives: Our aim was to evaluate the efficacy of chlorine dioxide-containing mouthwashes in comparison with other previously established mouth rinses in healthy adults using oral hygiene indices. Methods: This work was registered in PROSPERO (CRD42018099059) and carried out using multiple databases and reported according to the PRISMA statement. The following search terms were used “chlorine dioxide” AND “oral”, only randomised controlled trials (RCTs) were included. The primary outcome was the alteration of the plaque index (PI), while the secondary outcomes were the gingival index (GI) and bacterial counts. For the risk of bias assessment, the Cochrane Risk of Bias Tool was used. Statistical analysis for data heterogeneity was performed by Q-value and I2 -tests. Results: 364 articles were found in the databases. After the selection process, only five RCTs were eligible for meta-analysis. Data heterogeneity was low. There were no statistical differences in effectiveness between chlorine dioxide and the other effective mouth rinses in PI (0.720±0.119 vs 0.745±0.131; 95%; confidence intervals (CIs): 0.487–0.952 vs 0.489– 1.001, respectively) and GI (0.712±0.130 vs 0.745±0.131; 95% CIs: 0.457–0.967 vs 0.489– 1.001, respectively) and also in bacterial counts. Conclusion: Chlorine dioxide reduces both plaque and gingival indices and bacterial counts in the oral cavity similar to other routinely used oral rinses, however, the evidence supporting this is very limited. Therefore, further large scale RCTs are needed to decrease the risk of bias.

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Tracking of the degradation process of chlorhexidine digluconate and ethylenediaminetetraacetic acid in the presence of hyper-pure chlorine dioxide in endodontic disinfection

Cited by 10 publications

References 25 publications

Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Proton Nuclear Magnetic Resonance Spectroscopy Analysis of Mixtures of Chlorhexidine with Different Oxidizing Agents Activated by Photon-Induced Photoacoustic Streaming for Root Canal Irrigation

Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

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