Traditional Chinese medicine an approach to scientific proof and clinical validation

Yuan, Robert; Lin, Yuan

doi:10.1016/s0163-7258(00)00039-5

Cited by 292 publications

(162 citation statements)

References 16 publications

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“…In addition, when aiming at wind-phlegm syndrome, use Banxia Baizhu Tianma Tang (decoction of Pinellia ternata, Atractylodes macrocephala, and Gastrodia elata ) to calm the liver, strengthen the spleen, remove dampness, and reduce phlegm [35]. Chinese herbs such as Zexie ( Alisma ), Fuling ( Poria cocos ) [134], Zhuling ( Polyporus ) [135], and Banxia ( The tuber of pinellia ) [136] could effectively reduce BP as well. Fourthly, to remove blood stasis, use Xuefu Zhuyu Tang , a famous classical prescription recorded in Yi Lin Gai Cuo ( Correction of the Errors of Medical Works ) by Wang Qingren in the Qing Dynasty.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Wang

Xiong

Liu

2014

Evidence-Based Complementary and Alternative Medicine

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Background. To simplify traditional Chinese medicine syndrome differentiation and allow researchers to master syndrome differentiation for hypertension, this paper retrospectively studied the literature and analyzed syndrome elements corresponding to hypertension syndromes. Methods. Six databases including PubMed, EMBASE, Chinese Bio-Medical Literature Database, Chinese National Knowledge Infrastructure, Chinese Scientific Journal Database, and Wan-fang Data were searched from 1/January/2003 to 30/October/2013. We included all clinical literature testing hypertension syndromes and retrospectively studied the hypertension literature published from 2003 to 2013. Descriptive statistics calculated frequencies and percentages. Results. 13,272 patients with essential hypertension were included. Clinical features of hypertension could be attributed to 11 kinds of syndrome factors. Among them, seven syndrome factors were excess, while four syndrome factors were deficient. Syndrome targets were mainly in the liver and related to the kidney and spleen. There were 33 combination syndromes. Frequency of single-factor syndromes was 31.77% and frequency of two-factor syndromes was 62.26%. Conclusions. Excess syndrome factors of hypertension patients include yang hyperactivity, blood stasis, phlegm turbidity, internal dampness, and internal fire. Deficient syndrome factors of hypertension patients are yin deficiency and yang deficiency. Yin deficiency with yang hyperactivity, phlegm-dampness retention, and deficiency of both yin and yang were the three most common syndromes in clinical combination.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Wang

Xiong

Liu

2014

Evidence-Based Complementary and Alternative Medicine

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“…There are a large number of herbal formulations in TCMs, most of them contain a mixture of herbs, and multiple constituents are responsible for their bioactivities. These biologically active substances can be observed to have the following effects: mutual accentuation, mutual enhancement, mutual counteraction, mutual suppression, mutual antagonism, and mutual incompatibility (Yuan & Lin, 2000). However, the biologically active substances and the therapeutic mechanisms of most TCMs are still unclear due to the complexity of the chemical compositions of TCMs.…”

Section: Discussionmentioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

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“…Chinese medicine, on the other hand, defines health in terms of balance, and medications are designed to restore that balance by interacting with a wide variety of targets. Therefore, to uncover the mystery of traditional Chinese medicines and increase its application, the therapeutic approach using traditional Chinese medicine and natural products require a rigorous approach that includes chemical standardization, biological assays, animal models, and clinical trials (49).…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effect of traditional Chinese medicine and natural products

Chen¹,

Lian²,

Lyu³

et al. 2016

Eur J Bio Med Res

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Abstract:As obesity has become a worldwide health problem over the past three decades, more emphasis are placed on the prevention and treatment of obesity.Research in the nutrition field has recently aroused considerable interest based on the potential of traditional Chinese medicine and natural products to counteract obesity. This review focuses on the anti-obesity action usingtraditional Chinese medicine and natural products. Some present potent anti-obesity effects because of their ability to reduce blood lipid or blood glucose while others could be used for the treatment of obesity as lipase inhibitor, lipid metabolism regulators, appetite suppressants or fatty acid synthase inhibitor. Further study should be conducted in the mechanisms and active ingredients of traditional Chinese medicine and natural products.

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Traditional Chinese medicine an approach to scientific proof and clinical validation

Cited by 292 publications

References 16 publications

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Anti-obesity effect of traditional Chinese medicine and natural products

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