Traditional Chinese medicine for modern treatment of Parkinson’s disease

Han, Lijun; Xie, Yuanhong; Wu, Rong; Chen, Chen; Zhang, Yan; Wang, Xiaoping

doi:10.1007/s11655-016-2537-7

Cited by 20 publications

(5 citation statements)

References 41 publications

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“…Traditional Asian medical treatments may have an underlying scientific basis for their treatment of PD ( 24 ). Acupressure, a CAM sensory manipulation, holds potential in the treatment of ON-FOG.…”

Section: Introductionmentioning

confidence: 99%

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Miyahara,

Phokaewvarangkul,

Kerr

et al. 2024

Front. Neurol.

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BackgroundON-freezing of gait (ON-FOG) in Parkinson’s disease (PD), often resistant to medication, is linked to sensory deficits and proprioceptive impairment, and results in falls and reduced life quality. While visual cues from a laser cane (LC), which rapidly accesses the motor cortex, are commonly used to compensate for proprioceptive impairment, increased visual reliance may be affected by disease progression. Emerging evidence suggests that modulation of peripheral sensory processing may alleviate ON-FOG, and therapeutic Thai acupressure (TTA) may be a solution. This study aims to evaluate the effect of TTA in alleviating ON-FOG and compare its effectiveness to LC in patients with PD.MethodsThis open-label, non-inferiority trial randomized 90 PD patients with ON-FOG equally into three arms: TTA for plantar nerve stimulation for 96 s, LC for visual cueing, and sham control (SC). Stride length was the primary non-inferiority endpoint [non-inferiority margin: lower limit of 95% confidence interval (CI) above −10 cm in mean change difference in pre- and immediately post-intervention in TTA versus LC (one-sided)]. Secondary outcomes included FOG episodes, double support time, velocity, cadence, step length, timed up and go (TUG) test, and visual analog scale (VAS) score.ResultsTTA showed non-inferiority to LC in stride length (mean = −0.7 cm; 95% CI: −6.55; 5.15) (one-sided). The improvements with TTA and LC versus SC were comparable between (mean = 13.11 cm; 95% CI: 7.26; 18.96) and (mean = 13.8 cm; 95% CI: 7.96; 19.65) (one-sided). Secondary outcomes favored TTA and LC over SC with improved FOG, velocity, step length, and VAS scores, while only TTA resulted in improved double support time, cadence, and TUG test results. No complications occurred.ConclusionThe efficacy of TTA, which improves stride length, is non-inferior to that of LC and consequently alleviates FOG comparable to LC. TTA might enhance proprioceptive function and reduce visual dependence. Therefore, TTA, characterized by its non-invasive, simple, and safe techniques, is a potential non-pharmacological alternative for ON-FOG treatment and might enhance overall quality of life. However, further research into the mechanism, efficacy, and utilization of TTA is essential.Clinical trial registrationhttps://www.thaiclinicaltrials.org/show/TCTR20200317001, identifier TCTR20200317001.

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Section: Introductionmentioning

confidence: 99%

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Miyahara,

Phokaewvarangkul,

Kerr

et al. 2024

Front. Neurol.

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“…Based on a retrospective review of the historical role of a number of Chinese herbal medicines in the amelioration of tremor, it was shown that the Shakuyaku-kanzo-to might potentially provide natural treatment for PD. 16 However, its active ingredients and molecular mechanisms are unknown. Paeoniflorin (PF) and glycyrrhetinic acid (GA) are main active phytocompounds of Shakuyaku-kanzo-to.…”

Section: ■ Introductionmentioning

confidence: 99%

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP⁺/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

Dong

Zhang

Hua

et al. 2021

ACS Chem. Neurosci.

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Recently, combination therapy has proven to be an effective strategy for treating polygenic/multifactorial/complex disorder such as Parkinson’s disease (PD). Here, we hypothesized that dual up-regulation of glutamate cysteine ligase (GCL) catalytic subunit (GCLc) and GCL modifier subunit (GCLm) via nuclear factor E2-related factor (Nrf2) contribute to the antioxidant effect of paeoniflorin (PF) synergistically with glycyrrhetinic acid (GA) (henceforth called PF/GA) in the context of MPP+/MPTP neurotoxicity. Expectedly, CompuSyn synergism/antagonism analysis showed that PF/GA exerts synergistic neuroprotection. Moreover, the antioxidant effect of PF was significantly enhanced by the combined administration of GA, although GA alone did not confer the effect. Mechanistically, PF triggered extracellular signal-regulated kinase (ERK1/2) phosphorylation, resulting in Nrf2 nuclear translocation from cytoplasmic pool via de novo synthesis in MPP+-challenged SH-SY5Y cells. Concomitantly, GA activates Akt which in turn induces nuclear accumulation of Nrf2. Especially, PF/GA up-regulated glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase modifier subunit (Gclm) are formed via two separate pathways. Furthermore, these results were confirmed through pathway blockade assays using PD98059 (ERK1/2 inhibitor), LY294002 (phosphatidylinositol-3-kinase inhibitor), and shRNA-induced Nrf2 knockdown. Additionally, using a mouse MPTP-induced model of PD, we demonstrated that PF/GA synergistically ameliorates both motor deficits and oxidative stress in the ventral midbrain. In parallel, PF/GA also up-regulated both GCLc and GCLm expression at levels of transcription and translation. Conversely, antiparkinsonism and antioxidant effects of PF/GA were not observed in Nrf2-knockout MPTP-mice. Collectively, these results show that ERK1/2 and Akt activation contribute to the synergistic antioxidant effect of PF/GA. Hence, PF/GA regimen warrants further preclinical and possible clinical study for PD.

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“…In addition, traditional Chinese herbs or herbal extracts and non-pharmacological interventions are proven beneficial to patients with neurdegenerative disorders, by exerting antioxidant and anti-inflammatory effects [ 236 , 237 ]. Clinically, several studies showed that acupuncture [ 238 ] and Yang-Xue-Qing-Nao granules [ 239 ] improve sleep quality in PD patients.…”

Section: Therapeutic Strategies For Circadian Dysfunction and Sleep D...mentioning

confidence: 99%

Circadian disruption and sleep disorders in neurodegeneration

Shen

Xie

et al. 2023

Transl Neurodegener

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Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.

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Traditional Chinese medicine for modern treatment of Parkinson’s disease

Cited by 20 publications

References 41 publications

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP⁺/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

Circadian disruption and sleep disorders in neurodegeneration

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Traditional Chinese medicine for modern treatment of Parkinson’s disease

Cited by 20 publications

References 41 publications

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Comparing the efficacy of therapeutic Thai acupressure on plantar acupoints and laser cane therapy on freezing of gait in Parkinson’s disease: a randomized non-inferiority trial

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

Circadian disruption and sleep disorders in neurodegeneration

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Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP⁺/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms