Traditional Medicine for Memory Enhancement

Howes, Melanie‐Jayne R.; Houghton, Peter J.

doi:10.1007/978-3-540-79116-4_15

Cited by 18 publications

(13 citation statements)

References 402 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jujubogenin glycosides occur in Bacopa monnieri Wettst. (Scrophulariaceae), 129 a plant widely-studied for effects on cognition; 130 semi-synthetic derivatives are described in a patent as AChE inhibitors for potential use in AD. 36 Other triterpenoid or steroidal derivatives have been described, which are not AChE inhibitors, but may have some therapeutic potential as they possess additional activities relevant to dementia.…”

Section: Acetylcholinesterase Inhibitors (Cholinergic Hypothesis)mentioning

confidence: 99%

Natural products as a source of Alzheimer's drug leads

2011

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Acetylcholinesterase Inhibitors (Cholinergic Hypothesis)mentioning

confidence: 99%

Natural products as a source of Alzheimer's drug leads

2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…‐Genistein is neuroprotective against Aβ‐induced neurotoxicity and ameliorates Aβ‐induced hippocampal neuronal apoptosis in vitro (Mecocci et al, ; De Domenico and Giudetti, ; Howes & Houghton, )…”

Section: Phytochemicals As Nutraceuticalsmentioning

confidence: 99%

“…-A high-soya diet (100 mg of total isoflavone daily for 10 weeks) in student volunteers was suggested to improve shortand long-term memory in both females and males -Consumption of soya isoflavones by postmenopausal women for a period of 12 weeks improved cognitive functions, and in a double-blind RCT, some cognitive benefits, particularly verbal memory, occurred in postmenopausal women taking isoflavone supplements for 6 months (Howes & Houghton, 2009) -Long-term (30 months) supplementation in women showed no benefits on global cognition but improved visual memory -12-week supplementation in men improved spatial working memory only in men (Mecocci et al, 2014) ameliorated memory deficits, although in this study, this effect was correlated with a reversal of the reduced hippocampal choline acetyltransferase (ChAT) expression (Lim et al, 2016).…”

Section: Isoflavonesmentioning

confidence: 99%

Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing

Howes

Perry²,

Vásquez-Londoño

et al. 2020

British J Pharmacology

View full text Add to dashboard Cite

Cognitive decline can occur with normal ageing and in age‐related brain disorders, such as mild cognitive impairment and dementia, including Alzheimer's disease, with limited pharmacological therapies available. Other approaches to reduce cognitive decline are urgently needed, and so, the role of dietary interventions or nutraceuticals has received much attention in this respect. In this review, we examine the evidence for dietary plants and their chemical constituents as nutraceuticals, relevant to both cognitive decline in normal ageing and in dementia. Pharmacological (in vitro and in vivo), clinical and epidemiological evidence is assessed for both frequently consumed plants and their dietary forms, including tea, coffee, cocoa (chocolate), red wine, grapes, citrus and other fruits; in addition to plants used less frequently in certain diets and those that cross the blurred boundaries between foods, nutraceuticals and medicinal plants. For the latter, turmeric, saffron, sage, rosemary and lemon balm are examples of those discussed. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

“…apoptotic proteins and affect amyloid precursor protein metabolism [25]. It is a potent and reversible acetylcholinesterase inhibitor [24,26]. Currently, Huperzine A has been approved as a memory enhancing dietary supplement [26].…”

Section: The Mediterranean Dietmentioning

confidence: 99%

“…It is a potent and reversible acetylcholinesterase inhibitor [24,26]. Currently, Huperzine A has been approved as a memory enhancing dietary supplement [26]. In a clinical setting, it has been shown to improve cognition with few side effects [27].…”

Section: The Mediterranean Dietmentioning

confidence: 99%