Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

Estimation of antioxidant potential of individual components present in complex mixture ofWithania somnifera(Ashwagandha) root fraction by thin-layer chromatography-2,2-diphenyl-1-picrylhdrazyl method

“…The multicomponent extracts show better medicinal efficiency than purified components, i.e., the strength of herbal medicine increased with the mixture of secondary metabolites instead of a single component [29,30]. Keeping this in mind, we prepared a withanolide-rich fraction from roots of W. somnifera.…”

Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b

“…Celastrol was identified to be a pentacyclic triterpenoid, belonging to a small category of natural products of triterpene quinine methides (1,2). Containing electrophilic sites within the rings of quinone methide structure, celastrol is able to form covalent Michael adducts with the nucleophilic thiol groups of cysteine residues (3,4). This appears to be the mechanism underlying celastrol-mediated effects on the functions of various proteins, although the structural determinants in proteins can also regulate their interaction with celastrol and the covalent adducts formation (5).…”

Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process

“…Conventional drug development is slow and expensive and often the finished products are unavailable and unaffordable to resource-limited countries, unless when made available by donors from high-income countries, under heavily subsidized schemes (50). For most phytomedicines, drug development from complimentary and alternative medicines usually follows a "reverse pharmacology" approach (51,52).…”